Patient Derived Ex-Vivo Cancer Models in Drug Development, Personalized Medicine, and Radiotherapy

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

(2022) Adele M. Nicolas et al.   CANCER CELL

Engineering brain assembloids to interrogate human neural circuits

(2022) Yuki Miura et al.   Nature Protocols

Modulation of designer biomimetic matrices for optimized differentiated intestinal epithelial cultures

(2022) Wang Xi et al.   BIOMATERIALS

Radiation-induced toxicity in rectal epithelial stem cell contributes to acute radiation injury in rectum

(2021) Felipe Rodriguez Tirado et al.   Stem Cell Research & Therapy

Experimental Models to Study COVID-19 Effect in Stem Cells

(2021) Rishi Man Chugh et al.   Cells

Organoid Cultures Derived From Patients With Papillary Thyroid Cancer

(2021) Dong Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Patient-Derived Organoid-Based Radiosensitivity Model for the Prediction of Radiation Responses in Patients with Rectal Cancer

(2021) Misun Park et al.   Cancers

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

(2021) Xiaoqi Mao et al.   Molecular Cancer

Challenges for the Applications of Human Pluripotent Stem Cell-Derived Liver Organoids

(2021) Mingyang Chang et al.   Frontiers in Cell and Developmental Biology

Synthetic Matrices for Intestinal Organoid Culture: Implications for Better Performance

(2021) Humendra Poudel et al.   ACS Omega

Towards Multidrug Adaptive Therapy

(2020) Jeffrey West et al.   CANCER RESEARCH

Pan-cancer analysis of whole genomes

(2020)   NATURE

Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

(2020) Magdalena Kasendra et al.   eLife

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model

(2020) Xuelu Li et al.   Cancer Cell International

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases to direct personalized therapy

(2020) Vignesh Narasimhan et al.   CLINICAL CANCER RESEARCH

Radiation therapy for patients with locally advanced pancreatic cancer: Evolving techniques and treatment strategies

(2020) Joseph Abi Jaoude et al.   CURRENT PROBLEMS IN CANCER

Short-term organoid culture for drug sensitivity testing of high-grade serous carcinoma

(2020) Hui Chen et al.   GYNECOLOGIC ONCOLOGY

A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

(2020) Y Baert et al.   HUMAN REPRODUCTION

Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?

(2020) Herbert H-F. Loong et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

(2020) Ozge Saatci et al.   Nature Communications

Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells

(2020) Xingru Li et al.   Cancers

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

(2020) Brisa Palikuqi et al.   NATURE

PDX-derived organoids model in vivo drug response and secrete biomarkers

(2020) Ling Huang et al.   JCI Insight

In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity

(2019) Alican Ozkan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

(2019) Gitte Berkers et al.   Cell Reports

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

(2019) Luke Bu et al.   ONCOGENE

Tubuloids derived from human adult kidney and urine for personalized disease modeling

(2019) Frans Schutgens et al.   NATURE BIOTECHNOLOGY

A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA)

(2019) Nadja M. Meindl-Beinker et al.   BMC CANCER

Auranofin protects intestine against radiation injury by modulating p53/p21 pathway and radio-sensitizes human colon tumor

(2019) Dhrubajyoti Nag et al.   CLINICAL CANCER RESEARCH

Image Guided Adaptive External Beam Radiotherapy (EBRT) Planning for Cervical Cancer - a Comparison of Offline, Online and MRI-Guided Techniques to Reduce Organ at Risk (OAR) Dose Using a Dose Accumulation Model

(2019) I. White et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Effectiveness of intensive clinical and radiological follow-up in patients with surgically resected NSCLC. Analysis of 2661 patients from the prospective MAGRIT trial

(2019) Fabio Conforti et al.   EUROPEAN JOURNAL OF CANCER

Murine intestinal organoids resemble intestinal epithelium in their microRNA profiles

(2018) Fumina Ohsaka et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

(2018) Susan Tsai et al.   BMC CANCER

The Evolution of Tumour Composition During Fractionated Radiotherapy: Implications for Outcome

(2018) Thomas D. Lewin et al.   BULLETIN OF MATHEMATICAL BIOLOGY

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment

(2018) Herve Tiriac et al.   GASTROINTESTINAL ENDOSCOPY

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury

(2018) Payel Bhanja et al.   Stem Cell Research & Therapy

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids

(2018) Sarah J. Hill et al.   Cancer Discovery

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells

(2018) Julio Aleman et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Bile-derived organoids from patients with primary sclerosing cholangitis recapitulate their inflammatory immune profile

(2018) Carol J. Soroka et al.   HEPATOLOGY

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protocol for the STRONG trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma, a phase I feasibility study

(2018) Merel S Koedijk et al.   BMJ Open

Fluorometric Quantification of Single-Cell Velocities to Investigate Cancer Metastasis

(2018) Erin Elizabeth Edwards et al.   Cell Systems

Humanized mouse models: Application to human diseases

(2017) Ryoji Ito et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

(2017) Thomas Borchert et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Generation of stable PDX derived cell lines using conditional reprogramming

(2017) Alexandra Borodovsky et al.   Molecular Cancer

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

(2017) Julia Jabs et al.   Molecular Systems Biology

CAR-T's forge ahead, despite Juno deaths

(2017) Laura DeFrancesco   NATURE BIOTECHNOLOGY

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Kynurenine pathway metabolism and the microbiota-gut-brain axis

(2017) P.J. Kennedy et al.   NEUROPHARMACOLOGY

Irritable Bowel Syndrome

(2017) Alexander C. Ford et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal cues regulate the pancreatic cancer epigenome and metabolome

(2017) Mara H. Sherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval

(2017) Vinay Prasad et al.   JAMA Internal Medicine

Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation

(2017) Xuetao Sun et al.   Jove-Journal of Visualized Experiments

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype

(2016) Kelly M. Mabry et al.   BIOMATERIALS

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2 + T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate

(2016) Nicholas A. Zumwalde et al.   Cancer Prevention Research

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Radiation Therapy Noncompliance and Clinical Outcomes in an Urban Academic Cancer Center

(2016) Nitin Ohri et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

(2016) Kengo Nozaki et al.   JOURNAL OF GASTROENTEROLOGY

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

(2016) Carla S Verissimo et al.   eLife

Programmable Laser-Assisted Surface Microfabrication on a Poly(Vinyl Alcohol)-Coated Glass Chip with Self-Changing Cell Adhesivity for Heterotypic Cell Patterning

(2015) Yi-Chen Li et al.   ACS Applied Materials & Interfaces

Oncology 2020: a drug development and approval paradigm

(2015) K. Dhingra   ANNALS OF ONCOLOGY

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

(2015) W.G. Jiang et al.   SEMINARS IN CANCER BIOLOGY

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

(2015) Mirjana Kessler et al.   Nature Communications

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Role of P-Glycoprotein on the Brain Penetration and Brain Pharmacodynamic Activity of the MEK Inhibitor Cobimetinib

(2014) Edna F. Choo et al.   MOLECULAR PHARMACEUTICS

Single luminal epithelial progenitors can generate prostate organoids in culture

(2014) Chee Wai Chua et al.   NATURE CELL BIOLOGY

Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

(2014) Hugo J. W. L. Aerts et al.   Nature Communications

Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer

(2012) P. van Hagen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis

(2011) Katrin M Sjoquist et al.   LANCET ONCOLOGY

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

MAGRIT: The Largest-Ever Phase III Lung Cancer Trial Aims to Establish a Novel Tumor-Specific Approach to Therapy

(2009) Preeta Tyagi et al.   Clinical Lung Cancer

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of Planned Treatment Breaks During Radiation Therapy for Anal Cancer: Update of RTOG 92-08

(2008) Andre Konski et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY