Development of mouse models of angiosarcoma driven by p53

An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias

(2018) Ruairi W. Lynch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma

(2018) Michelle L. Chadwick et al.   Oncotarget

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

(2018) Meghan Riddell et al.   Nature Communications

Pericytes, integral components of adult hematopoietic stem cell niches

(2017) D. Sá da Bandeira et al.   PHARMACOLOGY & THERAPEUTICS

Pdgfrb-Cretargets lymphatic endothelial cells of both venous and non-venous origins

(2016) Maria H. Ulvmar et al.   GENESIS

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype

(2016) Shingo Sato et al.   Cell Reports

Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling

(2015) Shaogang Sun et al.   CANCER CELL

Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer

(2015) Helen Creedon et al.   Disease Models & Mechanisms

Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway

(2015) Rajmohan Murali et al.   Oncotarget

Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma

(2015) Qingxia Wei et al.   Oncotarget

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

(2015) Lukas Stanczuk et al.   Cell Reports

Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

(2015) Lorena Landuzzi et al.   Oncotarget

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

(2014) Morvarid Farhang Ghahremani et al.   CELL CYCLE

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

(2014) Sam Behjati et al.   NATURE GENETICS

Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma

(2013) N. J. Andersen et al.   MOLECULAR CANCER THERAPEUTICS

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation

(2013) Alexander Birbrair et al.   STEM CELLS AND DEVELOPMENT

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

(2012) Antoine Italiano et al.   CANCER

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

(2011) V M Renault et al.   ONCOGENE

Angiosarcoma

(2010) Guy Lahat et al.   ANNALS OF SURGERY

Deficiency in p53 but not Retinoblastoma Induces the Transformation of Mesenchymal Stem Cells In vitro and Initiates Leiomyosarcoma In vivo

(2010) R. Rubio et al.   CANCER RESEARCH

Angiosarcoma

(2010) Robin J Young et al.   LANCET ONCOLOGY

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Alveolar rhabdomyosarcoma: Is the cell of origin a mesenchymal stem cell?

(2008) Elizabeth Charytonowicz et al.   CANCER LETTERS

All MSCs Are Pericytes?

(2008) Arnold I. Caplan   Cell Stem Cell

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Efficient, inducible Cre-recombinase activation in vascular endothelium

(2008) Suzanne Claxton et al.   GENESIS

NG2 expression predicts the metastasis formation in soft-tissue sarcoma patients

(2008) Maria Serena Benassi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

FOXOs, cancer and regulation of apoptosis

(2008) Z Fu et al.   ONCOGENE