Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies

(2023) Nathalie Kyalu Ngoie Zola et al.   Nature Communications

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

(2022) Chae Kim et al.   Science Translational Medicine

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification

(2021) Airi Tarutani et al.   BRAIN

Tau strains shape disease

(2021) Jaime Vaquer-Alicea et al.   ACTA NEUROPATHOLOGICA

A current view on Tau protein phosphorylation in Alzheimer's disease

(2021) Susanne Wegmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

To target Tau pathologies, we must embrace and reconstruct their complexities

(2021) Galina Limorenko et al.   NEUROBIOLOGY OF DISEASE

Transmission of tauopathy strains is independent of their isoform composition

(2020) Zhuohao He et al.   Nature Communications

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

(2020) Yuxing Xia et al.   Acta Neuropathologica Communications

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

The Evolution of Tau Phosphorylation and Interactions

(2019) Nataliya I. Trushina et al.   Frontiers in Aging Neuroscience

Impaired tau–microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations

(2019) Yuxing Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

(2019) Mahmood Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

(2018) Garrett S. Gibbons et al.   JAMA Neurology

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

(2017) Kevin H. Strang et al.   Acta Neuropathologica Communications

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

(2017) Samantha B. Nicholls et al.   PLoS One

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE