To target Tau pathologies, we must embrace and reconstruct their complexities

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

(2021) Carolina Alquezar et al.   Frontiers in Neurology

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer’s disease

(2021) Ellen Singleton et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Structure of Tau filaments in Prion protein amyloidoses

(2021) Grace I. Hallinan et al.   ACTA NEUROPATHOLOGICA

Cellular and pathological heterogeneity of primary tauopathies

(2021) Dah-eun Chloe Chung et al.   Molecular Neurodegeneration

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

(2021) Pijush Chakraborty et al.   Nature Communications

Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?

(2021) Hilal A. Lashuel   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

(2020) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

(2020) Anne-Laure Mahul-Mellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan Sulfate Proteoglycans Undergo Differential Expression Alterations in Alzheimer Disease Brains

(2020) Laura Lorente-Gea et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mechanisms of Heparin-Induced Tau Aggregation Revealed by a Single Nanopore

(2020) Nicoletta Giamblanco et al.   ACS Sensors

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

(2020) Larissa-Nele Schaffert et al.   Brain Sciences

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

(2020) Sarah A. Kent et al.   ACTA NEUROPATHOLOGICA

Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies

(2020) Francesca Munari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Truncation of tau selectively facilitates its pathological activities

(2020) Jianlan Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration

(2020) Laibaik Park et al.   NATURE NEUROSCIENCE

Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin

(2020) David Townsend et al.   BIOCHEMISTRY

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau

(2019) Minh Bao Huynh et al.   PLoS One

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

(2019) Clément Despres et al.   ACS Chemical Biology

Elucidating Tau function and dysfunction in the era of cryo-EM

(2019) Guy Lippens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Closed-Loop Implantable Therapeutic Neuromodulation Systems Based on Neurochemical Monitoring

(2019) Khalid B. Mirza et al.   Frontiers in Neuroscience

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

(2019) Mahmood Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

(2019) Tobey J Betthauser et al.   BRAIN

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

(2019) Youssra K. Al‐Hilaly et al.   FEBS LETTERS

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

(2019) Yann Fichou et al.   Frontiers in Neuroscience

FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling

(2018) Huajie Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

(2018) Yann Fichou et al.   CHEMICAL COMMUNICATIONS

The Involvement of Post-Translational Modifications in Alzheimer’s Disease

(2018) Serena Marcelli et al.   Current Alzheimer Research

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

(2018) Auriane Maïza et al.   FEBS LETTERS

Metal Ion Effects on Aβ and Tau Aggregation

(2018) Anne Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development

(2018) Marco M. Hefti et al.   PLoS One

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Conformational heterogeneity of tau: Implication on intrinsic disorder, acid stability and fibrillation in Alzheimer's disease

(2018) Benita Jebarupa et al.   BIOPHYSICAL CHEMISTRY

Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms

(2018) Hilary A. Weismiller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

(2018) Youssra K. Al-Hilaly et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease

(2018) Measho H. Abreha et al.   PROTEOMICS

In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes

(2018) Kaoru Yamada   Jove-Journal of Visualized Experiments

The involvement of tau in nucleolar transcription and the stress response

(2018) Mahmoud B. Maina et al.   Acta Neuropathologica Communications

Cofactors are essential constituents of stable and seeding-active tau fibrils

(2018) Yann Fichou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimally Invasive Microelectrode Biosensors Based on Platinized Carbon Fibers for in Vivo Brain Monitoring

(2018) Charles Chatard et al.   ACS Central Science

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

(2018) Gwendoline Bourré et al.   Frontiers in Endocrinology

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A validated antibody panel for the characterization of tau post-translational modifications

(2017) Ebru Ercan et al.   Molecular Neurodegeneration

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Review: Tau in biofluids - relation to pathology, imaging and clinical features

(2017) H. Zetterberg   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system

(2017) Jialing Zhang et al.   Science Translational Medicine

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

(2017) Abdullah R. Chaudhary et al.   TRAFFIC

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property

(2016) Kefu Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates

(2016) Claire L. Russell et al.   JOURNAL OF ALZHEIMERS DISEASE

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Semi-synthesis of a tag-freeO-GlcNAcylated tau protein by sequential chemoselective ligation

(2016) Sergej Schwagerus et al.   JOURNAL OF PEPTIDE SCIENCE

Immune pathogenesis of heparin-induced thrombocytopenia

(2016) Sanjay Khandelwal et al.   THROMBOSIS AND HAEMOSTASIS

Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules

(2016) Jennifer N. Rauch et al.   Cold Spring Harbor Perspectives in Medicine

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Native chemical ligation between asparagine and valine: Application and limitations for the synthesis of tri-phosphorylated C-terminal tau

(2015) Oliver Reimann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

(2015) Pritam Ganguly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

(2014) Anna Mietelska-Porowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Variability of CSF Alzheimer’s Disease Biomarkers: Implications for Clinical Practice

(2014) Stephanie J. B. Vos et al.   PLoS One

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metronidazole and Hydroxymetronidazole Central Nervous System Distribution: 1. Microdialysis Assessment of Brain Extracellular Fluid Concentrations in Patients with Acute Brain Injury

(2013) Denis Frasca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease

(2013) Jasmine Ramcharitar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors

(2013) L. S. Eberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perturbation of the heparin/heparin-sulfate interactome of human breast cancer cells modulates pro-tumourigenic effects associated with PI3K/Akt and MAPK/ERK signalling

(2013) Yunliang Chen et al.   THROMBOSIS AND HAEMOSTASIS

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Human fetal tau protein isoform: Possibilities for Alzheimer's disease treatment

(2012) Nataša Jovanov-Milošević et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tau Isoform Composition Influences Rate and Extent of Filament Formation

(2012) Qi Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

β-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR

(2012) Venita Daebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A peculiar constellation of tau pathology defines a subset of dementia in the elderly

(2011) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Ubiquitin is Associated with Early Truncation of Tau Protein at Aspartic Acid421 during the Maturation of Neurofibrillary Tangles in Alzheimer's Disease

(2011) Francisco García-Sierra et al.   BRAIN PATHOLOGY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Temporary secondary structures in tau, an intrinsically disordered protein

(2011) Anna Battisti et al.   MOLECULAR SIMULATION

Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers

(2011) Diane Slats et al.   NEUROBIOLOGY OF AGING

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Characterization of tau fibrillization in vitro

(2010) Shaohua Xu et al.   Alzheimers & Dementia

Three- and Four-repeat Tau Coassemble into Heterogeneous Filaments

(2010) Ayisha Siddiqua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability

(2010) Susanne Wegmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

(2009) Ilona B. Bruinsma et al.   ACTA NEUROPATHOLOGICA

Ubiquitination and cysteine nitrosylation during aging and Alzheimer's disease

(2009) Irène M. Riederer et al.   BRAIN RESEARCH BULLETIN

Heparin regulates colon cancer cell growth through p38 mitogen-activated protein kinase signalling

(2009) G. Chatzinikolaou et al.   CELL PROLIFERATION

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

Interaction between β-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer’s disease

(2008) Hajime Shimizu et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Pattern of Tau forms in CSF is altered in progressive supranuclear palsy

(2007) B. Borroni et al.   NEUROBIOLOGY OF AGING