Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding

(2018) Doris Ellmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

(2017) Nadine Ait-Bouziad et al.   Nature Communications

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Chemical Protein Synthesis Using a Second-Generation N-Acylurea Linker for the Preparation of Peptide-Thioester Precursors

(2015) Juan B. Blanco-Canosa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Impact of Tau Phosphorylation at Threonine 231

(2015) Martin Schwalbe et al.   STRUCTURE

Traceless Purification and Desulfurization of Tau Protein Ligation Products

(2014) Oliver Reimann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry

(2014) Robert E. Thompson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-based Models To Investigate Tau Aggregation

(2014) Sungsu Lim et al.   Computational and Structural Biotechnology Journal

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

(2013) M. Goedert et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

The Alzheimer’s Disease Related Tau Protein as a New Target for Chemical Protein Engineering

(2012) Malgorzata Broncel et al.   CHEMISTRY-A EUROPEAN JOURNAL

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules

(2009) Daniela Fischer et al.   BIOCHEMISTRY