Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

(2021) Sang-Gyun Kang et al.   BMC BIOLOGY

Structurally distinct external solvent-exposed domains drive replication of major human prions

(2021) Mohammad Khursheed Siddiqi et al.   PLoS Pathogens

Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation

(2020) Nathalie Daude et al.   ACTA NEUROPATHOLOGICA

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease

(2020) Diego Sepulveda-Falla et al.   ACTA NEUROPATHOLOGICA

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

(2019) Atsushi Aoyagi et al.   Science Translational Medicine

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

Highly Elevated Cerebrospinal Fluid Total Tau Level Reflects Higher Likelihood of Non-Amnestic Subtype of Alzheimer’s Disease

(2019) Jagan A. Pillai et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular pathology of neurodegenerative diseases: principles and practice

(2019) Gabor G Kovacs   JOURNAL OF CLINICAL PATHOLOGY

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation

(2018) Thomas C.T. Michaels et al.   Annual Review of Physical Chemistry

Tau filaments in neurodegenerative diseases

(2018) Michel Goedert   FEBS LETTERS

Rapidly Progressive Alzheimer’s Disease in Two Distinct Autopsy Cohorts

(2018) Jagan A. Pillai et al.   JOURNAL OF ALZHEIMERS DISEASE

Artificial strain of human prions created in vitro

(2018) Chae Kim et al.   Nature Communications

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

(2018) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Rapidly Progressive Alzheimer's Disease: A Multicenter Update

(2018) Christian Schmidt et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of Polypeptides in Neurofibrillary Tangles and Total Homogenates of Brains with Alzheimer's Disease by Tandem Mass Spectrometry

(2018) Benito Minjarez et al.   JOURNAL OF ALZHEIMERS DISEASE

Pre-Progression Rates in Alzheimer's Disease Revisited

(2018) Christian Schmidt et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

(2018) Allison Kraus et al.   ACTA NEUROPATHOLOGICA

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions

(2018) Qiuye Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau monomer encodes strains

(2018) Apurwa M Sharma et al.   eLife

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Prions and Protein Assemblies that Convey Biological Information in Health and Disease

(2016) David W. Sanders et al.   NEURON

Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease

(2016) Mark Cohen et al.   Prion

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPScSpecies

(2015) Charles E. Mays et al.   JOURNAL OF VIROLOGY

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions

(2015) Jiri G. Safar et al.   PLoS Pathogens

A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers

(2015) Geoffrey P. Noble et al.   PLoS Pathogens

Prion disease tempo determined by host-dependent substrate reduction

(2014) Charles E. Mays et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases

(2014) M Enamul Kabir et al.   Prion

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

(2013) David J. Irwin et al.   AMERICAN JOURNAL OF PATHOLOGY

Co-existence of Distinct Prion Types Enables Conformational Evolution of Human PrPScby Competitive Selection

(2013) Tracy Haldiman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSF prion protein concentration and cognition in patients with Alzheimer disease

(2013) Christian Schmidt et al.   Prion

Modeling the heterogeneity in risk of progression to Alzheimer's disease across cognitive profiles in mild cognitive impairment

(2013) Curtis Tatsuoka et al.   Alzheimers Research & Therapy

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Acquisition of Drug Resistance and Dependence by Prions

(2013) Anja M. Oelschlegel et al.   PLoS Pathogens

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Alzheimer’s Disease: Genetic Polymorphisms and Rate of Decline

(2012) Christian Schmidt et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

β-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR

(2012) Venita Daebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sporadic human prion diseases: molecular insights and diagnosis

(2012) Gianfranco Puoti et al.   LANCET NEUROLOGY

Molecular pathogenesis of sporadic prion diseases in man

(2012) Jiri G. Safar   Prion

New generation QuIC assays for prion seeding activity

(2012) Christina D. Orru et al.   Prion

Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Protease Sensitive Oligomers of PrPSc in Distinct Human Prions Determine Conversion Rate of PrPC

(2012) Chae Kim et al.   PLoS Pathogens

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease

(2011) Numthip Chitravas et al.   ANNALS OF NEUROLOGY

Rapidly Progressive Alzheimer Disease

(2011) Christian Schmidt   ARCHIVES OF NEUROLOGY

Variations in Filament Conformation Dictate Seeding Barrier between Three- and Four-Repeat Tau

(2011) Paul D. Dinkel et al.   BIOCHEMISTRY

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Protease-Sensitive Conformers in Broad Spectrum of Distinct PrPSc Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate

(2011) Chae Kim et al.   PLoS Pathogens

From tau phosphorylation to tau aggregation: what about neuronal death?: Figure 1

(2010) Luc Buée et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Clinical Features of Rapidly Progressive Alzheimer’s Disease

(2010) Christian Schmidt et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors

(2010) Jae-Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Darwinian Evolution of Prions in Cell Culture

(2010) J. Li et al.   SCIENCE

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Prion Diseases and Their Biochemical Mechanisms†

(2009) Nathan J. Cobb et al.   BIOCHEMISTRY

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Dominant Inhibition of Prion Propagation In Vitro Is Not Mediated by an Accessory Cofactor

(2009) James C. Geoghegan et al.   PLoS Pathogens

De Novo Generation of Infectious Prions In Vitro Produces a New Disease Phenotype

(2009) Marcelo A. Barria et al.   PLoS Pathogens

Rapidly progressive dementia

(2008) Michael D. Geschwind et al.   ANNALS OF NEUROLOGY

The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†

(2008) Sadasivam Jeganathan et al.   BIOCHEMISTRY

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA