Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

(2019) Nicolas R. Barthélemy et al.   Frontiers in Aging Neuroscience

Impaired tau–microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations

(2019) Yuxing Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau

(2019) Sneha Narasimhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Prion-like Spreading in Tauopathies

(2018) Jacob I. Ayers et al.   BIOLOGICAL PSYCHIATRY

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau

(2018) Cara L. Croft et al.   PLoS One

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Phosphorylation of serine 305 in tau inhibits aggregation

(2018) Kevin H. Strang et al.   NEUROSCIENCE LETTERS

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

(2017) Md Nazmul Huda et al.   Jove-Journal of Visualized Experiments

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

(2017) Kevin H. Strang et al.   Acta Neuropathologica Communications

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice

(2016) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

(2015) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

A Phosphorylation-Induced Turn Defines the Alzheimer’s Disease AT8 Antibody Epitope on the Tau Protein

(2015) Neha S. Gandhi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Cerebral amyloid angiopathy with and without hemorrhage: Evidence for different disease phenotypes

(2015) A. Charidimou et al.   NEUROLOGY

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

(2014) Ken C. Walls et al.   NEUROSCIENCE LETTERS

Physiological and pathological phosphorylation of tau by Cdk5

(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

GSK-3β, a pivotal kinase in Alzheimer disease

(2014) María Llorens-Marítin et al.   Frontiers in Molecular Neuroscience

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro

(2013) Jhoana Mendoza et al.   JOURNAL OF PROTEOME RESEARCH

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Combinatorial Tau Pseudophosphorylation

(2011) Erkan Kiris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau

(2011) Stefan Bibow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pseudophosphorylation of tau protein directly modulates its aggregation kinetics

(2010) Edward Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules

(2009) Daniela Fischer et al.   BIOCHEMISTRY

Pseudohyperphosphorylation Causing AD-like Changes in Tau Has Significant Effects on Its Polymerization

(2009) Qian Sun et al.   BIOCHEMISTRY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

(2008) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY