Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

(2022) Hiruy S. Meharena et al.   Cell Stem Cell

Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity

(2022) Katharina Lambert et al.   Science Translational Medicine

APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons

(2022) Chun-I Wu et al.   MOLECULAR PSYCHIATRY

Accelerated epigenetic aging in newborns with Down syndrome

(2022) Keren Xu et al.   AGING CELL

Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome

(2021) Helin Atas-Ozcan et al.   Genes

Health comorbidities and cognitive abilities across the lifespan in Down syndrome

(2020) Carla M. Startin et al.   Journal of Neurodevelopmental Disorders

Down syndrome

(2020) Stylianos E. Antonarakis et al.   Nature Reviews Disease Primers

The Laminopathies and the Insights They Provide into the Structural and Functional Organization of the Nucleus

(2020) Xianrong Wong et al.   Annual Review of Genomics and Human Genetics

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

(2020) Ivan Alić et al.   MOLECULAR PSYCHIATRY

De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity

(2020) Francesca Cristofoli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome

(2020) Hyuk Jin Yun et al.   CEREBRAL CORTEX

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

(2019) Vijay R. Menon et al.   CELL CYCLE

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

(2019) Steven E. Guard et al.   Scientific Reports

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

(2019) Julia Roewenstrunk et al.   Scientific Reports

TwinsUK: The UK Adult Twin Registry Update

(2019) Serena Verdi et al.   Twin Research and Human Genetics

An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

(2019) Natalie Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells are Linked to Replication-Associated DNA Damage and Repair

(2018) Haritha Vallabhaneni et al.   STEM CELLS

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells

(2018) Esteban J. Rozen et al.   Cell Reports

Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

(2018) Hai-Qin Huo et al.   Stem Cell Reports

Immunoglobulin G glycosylation in aging and diseases

(2018) Ivan Gudelj et al.   CELLULAR IMMUNOLOGY

DYRK1A and cognition: A lifelong relationship

(2018) Maria L. Arbones et al.   PHARMACOLOGY & THERAPEUTICS

Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP

(2017) Eric Doran et al.   JOURNAL OF ALZHEIMERS DISEASE

Nut Consumption and Cardiovascular Risk Factors: A Cross-Sectional Study in a Mediterranean Population

(2017) Ajka Relja et al.   Nutrients

Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain

(2017) Concetta Dagostino et al.   PLoS One

Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

(2017) Sameehan Mahajani et al.   Scientific Reports

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Lamin B1 protein is required for dendrite development in primary mouse cortical neurons

(2016) Caterina Giacomini et al.   MOLECULAR BIOLOGY OF THE CELL

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Effects of allergic diseases and age on the composition of serum IgG glycome in children

(2016) Marija Pezer et al.   Scientific Reports

Accelerated epigenetic aging in Down syndrome

(2015) Steve Horvath et al.   AGING CELL

Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts

(2015) Daniela Necchi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

(2015) Aoife Murray et al.   STEM CELLS

Global Reorganization of the Nuclear Landscape in Senescent Cells

(2015) Tamir Chandra et al.   Cell Reports

The role of lamin B1 for the maintenance of nuclear structure and function

(2015) Jordi Camps et al.   Nucleus

The role of lamin B1 for the maintenance of nuclear structure and function

(2015) Jordi Camps et al.   Nucleus

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

(2015) Manuel Stemmer et al.   PLoS One

DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies

(2014) Walter Becker et al.   CNS & Neurological Disorders-Drug Targets

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Human Finger-Prick Induced Pluripotent Stem Cells Facilitate the Development of Stem Cell Banking

(2014) Hong-Kee Tan et al.   Stem Cells Translational Medicine

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

(2013) Oliver Dreesen et al.   JOURNAL OF CELL BIOLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Deficits in human trisomy 21 iPSCs and neurons

(2013) J. P. Weick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

The contrasting roles of lamin B1 in cellular aging and human disease

(2013) Oliver Dreesen et al.   Nucleus

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome

(2012) Y. Shi et al.   Science Translational Medicine

Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology

(2012) James A. Briggs et al.   STEM CELLS

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations

(2011) Maja Pučić et al.   MOLECULAR & CELLULAR PROTEOMICS

“10 001 Dalmatians:” Croatia Launches Its National Biobank

(2009) Igor Rudan et al.   CROATIAN MEDICAL JOURNAL

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development

(2008) Ariadna Laguna et al.   DEVELOPMENTAL CELL

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls

(2007) Philip Thomas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

DNA damage and repair in children with Down's syndrome

(2007) Zbigniew Morawiec et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS