A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis

(2019) Dan Yu et al.   NUCLEIC ACIDS RESEARCH

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

(2019) Vijay R. Menon et al.   CELL CYCLE

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations

(2018) Lev Litichevskiy et al.   Cell Systems

DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspective

(2018) Ankita Pathak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair

(2018) Liwei An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth

(2018) Jeroni Luna et al.   GUT

Genome integrity and disease prevention in the nervous system

(2017) Peter J. McKinnon   GENES & DEVELOPMENT

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18

(2017) Qi Hu et al.   MOLECULAR CELL

Dual-utility NLS drives RNF169-dependent DNA damage responses

(2017) Liwei An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

(2017) Julianne Kitevski-LeBlanc et al.   eLife

Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways

(2016) Jongchan Kim et al.   CANCER RESEARCH

Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling

(2016) Susanne Hille et al.   CARDIOVASCULAR RESEARCH

DYRK1A: A Promising Drug Target for Islet Transplant–Based Diabetes Therapies

(2016) Bengt-Frederik Belgardt et al.   DIABETES

E3 Ligase SCFβTrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells

(2016) Qiang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes

(2016) Jennifer G. Abelin et al.   MOLECULAR & CELLULAR PROTEOMICS

A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma

(2016) Aneesha Radhakrishnan et al.   Scientific Reports

Non-degradative Ubiquitination of Protein Kinases

(2016) K. Aurelia Ball et al.   PLoS Computational Biology

The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2

(2016) Florian Glenewinkel et al.   Scientific Reports

DYRK protein kinases

(2015) Ulf Soppa et al.   CURRENT BIOLOGY

Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomicDyrk1a

(2015) Joshua D. Blazek et al.   HUMAN MOLECULAR GENETICS

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I

(2015) Nana Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase

(2015) Chiara Di Vona et al.   MOLECULAR CELL

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

(2015) B W M van Bon et al.   MOLECULAR PSYCHIATRY

Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders

(2015) Jingjing Li et al.   Cell Systems

Tumor Suppressor DYRK1A Effects on Proliferation and Chemoresistance of AML Cells by Downregulating c-Myc

(2014) Qiang Liu et al.   PLoS One

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

(2014) Susana García-Cerro et al.   PLoS One

Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome

(2013) Ariadna Laguna et al.   HUMAN MOLECULAR GENETICS

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth

(2013) Natividad Pozo et al.   JOURNAL OF CLINICAL INVESTIGATION

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Protein Interaction Landscape of the Human CMGC Kinase Group

(2013) Markku Varjosalo et al.   Cell Reports

Systematic Identification of Proteins Binding to Chromatin-Embedded Ubiquitylated H2B Reveals Recruitment of SWI/SNF to Regulate Transcription

(2013) Efrat Shema-Yaacoby et al.   Cell Reports

Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage

(2012) Jie Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

(2012) Maria Poulsen et al.   JOURNAL OF CELL BIOLOGY

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway

(2012) J. Y. Hong et al.   JOURNAL OF CELL SCIENCE

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

(2012) Sébastien Malinge et al.   JOURNAL OF CLINICAL INVESTIGATION

Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks

(2012) Stephanie Panier et al.   MOLECULAR CELL

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells

(2011) A. Pines et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

(2010) Eric J. Bennett et al.   CELL

The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions

(2010) Stefanie Ritterhoff et al.   EMBO JOURNAL

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Domain That Transiently Converts Class 2 DYRKs into Intramolecular Tyrosine Kinases

(2010) R. Kinstrie et al.   Science Signaling

Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

(2009) Youngkyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonprimed and DYRK1A-primed GSK3 -phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons

(2009) T. M. E. Scales et al.   JOURNAL OF CELL SCIENCE