Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease

Hypoxia inducible factor 1α inhibitor PX-478 reduces atherosclerosis in mice

(2022) Nicolas Villa-Roel et al.   ATHEROSCLEROSIS

Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease

(2022) Francesco Bellanti et al.   Frontiers in Aging Neuroscience

Eradication of HCV by direct antiviral agents restores mitochondrial function and energy homeostasis in peripheral blood mononuclear cells

(2022) Rosanna Villani et al.   FASEB JOURNAL

Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages

(2022) Antonella Marrocco et al.   Frontiers in Immunology

The crosstalk between HIFs and mitochondrial dysfunctions in cancer development

(2021) Xingting Bao et al.   Cell Death & Disease

A Novel Nutraceuticals Mixture Improves Liver Steatosis by Preventing Oxidative Stress and Mitochondrial Dysfunction in a NAFLD Model

(2021) Moris Sangineto et al.   Nutrients

The BET inhibitor attenuates the inflammatory response and cell migration in human microglial HMC3 cell line

(2021) Mina Baek et al.   Scientific Reports

Microglia contribute to the propagation of Aβ into unaffected brain tissue

(2021) Paolo d’Errico et al.   NATURE NEUROSCIENCE

Reactive Oxygen Species in Macrophages: Sources and Targets

(2021) Marcella Canton et al.   Frontiers in Immunology

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

(2020) Junling Yang et al.   Frontiers in Immunology

Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages

(2020) Ronan Kapetanovic et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulations of Glycolytic Activities on Macrophages Functions in Tumor and Infectious Inflammation

(2020) Qing Yu et al.   Frontiers in Cellular and Infection Microbiology

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

(2020) Moira Marizzoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Toll Like Receptor 4 in Alzheimer’s Disease

(2020) Maria Calvo-Rodriguez et al.   Frontiers in Immunology

Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages

(2020) Weihua Yu et al.   Redox Biology

TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment

(2020) Yongji Zhou et al.   Frontiers in Neuroscience

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/d-galactosamine-induced acute hepatic damage in mice

(2019) Yongqiang Yang et al.   Innate Immunity

Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo

(2019) Amy Lewis et al.   Frontiers in Immunology

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

(2018) Xinhua Zhan et al.   Frontiers in Aging Neuroscience

Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer’s disease by exerting anti-inflammatory and neuroprotective effects

(2018) Caterina Scuderi et al.   Translational Psychiatry

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

(2018) Francesco Bellanti et al.   Redox Biology

Differential Regulation of Resolution in Inflammation induced by Amyloid-β42 and Lipopolysaccharides in Human Microglia

(2018) Mingqin Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

The human microglial HMC3 cell line: where do we stand? A systematic literature review

(2018) Cinzia Dello Russo et al.   Journal of Neuroinflammation

Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease

(2018) Tommaso Cassano et al.   EXPERIMENTAL NEUROLOGY

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer’s disease

(2016) Eleonora Gatta et al.   PHARMACOLOGICAL RESEARCH

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Many Faces of Mitochondrial Uncoupling During Age: Damage or Defense?

(2013) F. Bellanti et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

(2011) Kyeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

(2011) Tommaso Cassano et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Alzheimer's disease

(2009) Lennart Mucke   NATURE