Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy

Pre-clinical characterization of ISB 1342, a CD38xCD3 T-cell engager for relapsed/refractory multiple myeloma

(2023) Blandine Pouleau et al.   BLOOD

CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma

(2023) Elana Thieme et al.   Molecular Cancer

In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts

(2023) Joanna Randall et al.   PEDIATRIC BLOOD & CANCER

Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia

(2023) Mayumi Sugita et al.   Cell Death & Disease

HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models

(2023) Hang Ke et al.   Scientific Reports

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-derived Xenograft Mouse Model

(2023) Claudia Manriquez Roman et al.   Jove-Journal of Visualized Experiments

A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies

(2023) Roeland Lameris et al.   Cell Reports Medicine

Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity

(2023) Ida H. Hiemstra et al.   EBioMedicine

The Hematology of Tomorrow Is Here—Preclinical Models Are Not: Cell Therapy for Hematological Malignancies

(2022) Lorena Arranz   Cancers

The Coming of Age of Preclinical Models of MDS

(2022) Wei Liu et al.   Frontiers in Oncology

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

(2022) Rita Alaggio et al.   LEUKEMIA

CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment

(2022) Yujun Pei et al.   Frontiers in Immunology

Novel myeloma patient-derived xenograft models unveil the potency of anlotinib to overcome bortezomib resistance

(2022) Yanhua Yue et al.   Frontiers in Oncology

Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

(2022) Simona Caruso et al.   Journal of Hematology & Oncology

Naturally selected CD7 CAR-T therapy without genetic editing demonstrates significant antitumour efficacy against relapsed and refractory acute myeloid leukaemia (R/R-AML)

(2022) Yu Lu et al.   Journal of Translational Medicine

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

(2021) Xing Yi Woo et al.   NATURE GENETICS

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

(2021) Claire M. Patterson et al.   Communications Biology

Development of humanized mouse with patient‐derived xenografts for cancer immunotherapy studies: a comprehensive review

(2021) Ke‐Tao Jin et al.   CANCER SCIENCE

Extramedullary multiple myeloma patient derived orthotopic xenograft with high disturbed genome: combined exhaustive molecular and therapeutic studies

(2021) Lourdes Farre et al.   Disease Models & Mechanisms

Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response

(2021) Won‐Tae Kim et al.   EMBO JOURNAL

Recent progress on targeting leukemia stem cells

(2021) Xiang-Yu Ma et al.   DRUG DISCOVERY TODAY

Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant IDH1 for Treatment of IDH1-Mutant Malignancies

(2021) Yue Chen et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of Preclinical Activity of Isatuximab in Patients with Acute Lymphoblastic Leukemia

(2021) Anlai Wang et al.   MOLECULAR CANCER THERAPEUTICS

The cure of leukemia through the optimist's prism

(2021) Hagop M. Kantarjian et al.   CANCER

Humanized three-dimensional scaffold xenotransplantation models for myelodysplastic syndromes

(2021) Eva Altrock et al.   EXPERIMENTAL HEMATOLOGY

Immunotherapy in hematological malignancies: recent advances and open questions

(2021) Essam A Tawfik et al.   Immunotherapy

Preclinical pharmacology and toxicology evaluation of an anti-CD52 monoclonal antibody produced by perfusion fermentation process

(2021) Yanchao Wang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis

(2020) Shigeyoshi Fujiwara et al.   Pathogens

Myelodysplastic syndrome patient-derived xenografts: from no options to many

(2020) Christophe Côme et al.   HAEMATOLOGICA

Acute myeloid leukemia shapes the bone marrow stromal niche in vivo

(2020) Alice Pievani et al.   HAEMATOLOGICA

Impact of the Injection Site on Growth Characteristics, Phenotype and Sensitivity towards Cytarabine of Twenty Acute Leukaemia Patient-Derived Xenograft Models

(2020) Julia Schueler et al.   Cancers

Engineered off-the-shelf therapeutic T cells resist host immune rejection

(2020) Feiyan Mo et al.   NATURE BIOTECHNOLOGY

Efficacy of the Novel Tubulin Polymerization Inhibitor PTC‐028 for Myelodysplastic Syndrome

(2020) Cheng Zhong et al.   CANCER SCIENCE

Unraveling Hematopoiesis through the Lens of Genomics

(2020) L. Alexander Liggett et al.   CELL

Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity

(2020) Sandrine Poglio et al.   LEUKEMIA

Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

(2020) Kodandaram Pillarisetti et al.   Blood Advances

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

(2019) Yuanbin Song et al.   Nature Communications

The Future: In Vivo CAR T Cell Gene Therapy

(2019) Rana Mhaidly et al.   MOLECULAR THERAPY

Essential Role of HTLV-1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice

(2019) Veronica Galli et al.   JOURNAL OF VIROLOGY

Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models

(2019) Okada et al.   Cells

In vivo generated human CAR T cells eradicate tumor cells

(2019) Shiwani Agarwal et al.   OncoImmunology

PDGFB-expressing mesenchymal stem cells improve human hematopoietic stem cell engraftment in immunodeficient mice

(2019) Xiuxiu Yin et al.   BONE MARROW TRANSPLANTATION

Humanized Mouse Models for the Preclinical Assessment of Cancer Immunotherapy

(2018) Anja Kathrin Wege   BIODRUGS

Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition

(2018) Jo Ishizawa et al.   CANCER RESEARCH

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

(2018) Simon Haas et al.   Cell Stem Cell

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

(2018) Ander Abarrategi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Generation and Application of Patient-Derived Xenograft Model for Cancer Research

(2018) Jaeyun Jung et al.   Cancer Research and Treatment

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

(2018) Asami Hanazawa et al.   Frontiers in Immunology

Humanized Mice for the Study of Immuno-Oncology

(2018) Philippe De La Rochere et al.   TRENDS IN IMMUNOLOGY

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate

(2018) Kazuki Taoka et al.   Scientific Reports

PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia

(2018) Paulina Richter‐Pechańska et al.   EMBO Molecular Medicine

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis

(2018) Phuong M. Le et al.   HAEMATOLOGICA

Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia

(2018) Chun-Hui Jin et al.   EBioMedicine

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors

(2017) Jungmin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

(2017) Ander Abarrategi et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-Hodgkin lymphoma

(2017) James O Armitage et al.   LANCET

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

New proposals of the WHO working group (2016) for the diagnosis of myelodysplastic syndromes (MDS): Characteristics of refined MDS types

(2017) Corinna Strupp et al.   LEUKEMIA RESEARCH

Antitumor Activity of Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor, in ETV6-NTRK3 –Positive Acute Myeloid Leukemia

(2017) Kristen M. Smith et al.   MOLECULAR CANCER THERAPEUTICS

Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells

(2017) Iulia Diaconu et al.   MOLECULAR THERAPY

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice

(2017) Andreas Reinisch et al.   Nature Protocols

Chimeric antigen receptor T-cell therapy — assessment and management of toxicities

(2017) Sattva S. Neelapu et al.   Nature Reviews Clinical Oncology

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

(2017) Dietmar Herndler-Brandstetter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Humanized mouse models for Epstein Barr virus infection

(2017) Christian Münz   Current Opinion in Virology

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

(2017) Ikumi Katano et al.   Scientific Reports

Gill S, Tasian SK, Ruella M, et al. Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells. Blood . 2014;123(15):2343-2354.

(2016)   BLOOD

Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches

(2016) A. Antonelli et al.   BLOOD

Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease

(2016) B. Chapuy et al.   BLOOD

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

(2016) E. Drent et al.   HAEMATOLOGICA

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

(2016) Mingqiang Ren et al.   INTERNATIONAL JOURNAL OF CANCER

From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers

(2016) Adi F. Gazdar et al.   Journal of Thoracic Oncology

An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts

(2016)   MOLECULES AND CELLS

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

(2016) Andreas Reinisch et al.   NATURE MEDICINE

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice

(2016) Rituparna Das et al.   NATURE MEDICINE

Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model

(2016) H Qin et al.   ONCOGENE

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model

(2016) Shi-Dong Ma et al.   PLoS Pathogens

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

(2016) E. Drent et al.   HAEMATOLOGICA

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

(2016) Alvaro Muñoz-López et al.   Stem Cell Reports

Modeling Human Leukemia Immunotherapy in Humanized Mice

(2016) Jinxing Xia et al.   EBioMedicine

Xenograft models for normal and malignant stem cells

(2015) S. Goyama et al.   BLOOD

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

Conserved and divergent aspects of human T-cell development and migration in humanized mice

(2015) Joanna Halkias et al.   IMMUNOLOGY AND CELL BIOLOGY

Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2–Producing Transgenic NOG Mouse

(2015) Ikumi Katano et al.   JOURNAL OF IMMUNOLOGY

Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab

(2015) I S Nijhof et al.   LEUKEMIA

Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice

(2015) Eun Kyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis

(2015) Eléonore Pérès et al.   Viruses-Basel

Dissecting the role of aberrant DNA methylation in human leukaemia

(2015) Giovanni Amabile et al.   Nature Communications

Overcoming Antigen Escape with CAR T-cell Therapy

(2015) H. J. Jackson et al.   Cancer Discovery

A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

(2015) Eric J. Smith et al.   Scientific Reports

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

NOD/SCID-GAMMA Mice Are an Ideal Strain to Assess the Efficacy of Therapeutic Agents Used in the Treatment of Myeloma Bone Disease

(2015) Michelle A. Lawson et al.   PLoS One

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma

(2015) Nicola Amodio et al.   Oncotarget

Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice

(2014) Yoichi Haji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

(2014) J. Irving et al.   BLOOD

Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance

(2014) Nicholas C Wong et al.   BMC GENOMICS

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

(2014) Petter S. Woll et al.   CANCER CELL

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

(2014) Jeffery M. Klco et al.   CANCER CELL

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

(2014) S. K. Knutson et al.   MOLECULAR CANCER THERAPEUTICS

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells

(2014) M Askmyr et al.   Blood Cancer Journal

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice

(2014) Y. Chu et al.   Cancer Immunology Research

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models

(2013) M. Ren et al.   BLOOD

Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia

(2013) S. Gandre-Babbe et al.   BLOOD

Engraftment of low numbers of pediatric acute lymphoid and myeloid leukemias into NOD/SCID/IL2Rcγnull mice reflects individual leukemogenecity and highly correlates with clinical outcome

(2013) Jeanette Woiterski et al.   INTERNATIONAL JOURNAL OF CANCER

Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rgnull Mice

(2013) Jeannette Cany et al.   PLoS One

Intratibial Injection of Human Multiple Myeloma Cells in NOD/SCID IL-2Rγ(Null) Mice Mimics Human Myeloma and Serves as a Valuable Tool for the Development of Anticancer Strategies

(2013) Julia Schueler et al.   PLoS One

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

(2013) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r null mice is enhanced by transgenic expression of membrane-bound human SCF

(2012) M. A. Brehm et al.   BLOOD

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO

(2012) F.-S. Chou et al.   BLOOD

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

(2012) R. W. J. Groen et al.   BLOOD

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

(2012) K. Kumano et al.   BLOOD

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

(2012) M. Y. Chiang et al.   BLOOD

Non-Hodgkin lymphoma

(2012) Kate R Shankland et al.   LANCET

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice

(2011) E. Billerbeck et al.   BLOOD

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

Soft-Tissue Plasmacytomas in Multiple Myeloma: Incidence, Mechanisms of Extramedullary Spread, and Treatment Approach

(2011) Joan Bladé et al.   JOURNAL OF CLINICAL ONCOLOGY

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

(2011) A. Rongvaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

“Double-Hit” Mature B-Cell Lymphomas Show a Common Immunophenotype by Flow Cytometry That Includes Decreased CD20 Expression

(2010) David Wu et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells

(2010) A. Rizo et al.   BLOOD

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

Establishment of a xenograft model of human myelodysplastic syndromes

(2010) Y. Muguruma et al.   HAEMATOLOGICA

Characterization and IL-15 dependence of NK cells in humanized mice

(2010) Elisabeth A. Pek et al.   IMMUNOBIOLOGY

A New Model of Epstein-Barr Virus Infection Reveals an Important Role for Early Lytic Viral Protein Expression in the Development of Lymphomas

(2010) S.-D. Ma et al.   JOURNAL OF VIROLOGY

Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout mice

(2010) M G Martin et al.   LEUKEMIA

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

(2010) M Wunderlich et al.   LEUKEMIA

Ectopic Human Mesenchymal Stem Cell-Coated Scaffolds in NOD/SCID Mice: An In Vivo Model of the Leukemia Niche

(2010) Sarah R. Vaiselbuh et al.   TISSUE ENGINEERING PART C-METHODS

EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies

(2009) H. Yuling et al.   CANCER RESEARCH

4-1BB and CD28 Signaling Plays a Synergistic Role in Redirecting Umbilical Cord Blood T Cells Against B-Cell Malignancies

(2009) Syam Tammana et al.   HUMAN GENE THERAPY

Defucosylated Anti-CCR4 Monoclonal Antibody Exerts Potent ADCC against Primary ATLL Cells Mediated by Autologous Human Immune Cells in NOD/Shi-scid, IL-2R null Mice In Vivo

(2009) A. Ito et al.   JOURNAL OF IMMUNOLOGY

Many are called MDS cell lines: One is chosen

(2009) Hans G. Drexler et al.   LEUKEMIA RESEARCH

Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma

(2009) F. van Rhee et al.   MOLECULAR CANCER THERAPEUTICS

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model

(2008) Asahi Ito et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Non-obese diabetic-recombination activating gene-1 (NOD-Rag 1null) interleukin (IL)-2 receptor common gamma chain (IL 2 rγnull) null mice: a radioresistant model for human lymphohaematopoietic engraftment

(2008) T. Pearson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells

(2008) Seiji Okada et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A New Humanized Mouse Model of Epstein‐Barr Virus Infection That Reproduces Persistent Infection, Lymphoproliferative Disorder, and Cell‐Mediated and Humoral Immune Responses

(2008) Misako Yajima et al.   JOURNAL OF INFECTIOUS DISEASES