Humanized mouse model supports development, function, and tissue residency of human natural killer cells

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

(2016) Y. Mao et al.   BLOOD

Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I

(2016) Jeanette E. Boudreau et al.   IMMUNITY

Cognate HLA absence in trans diminishes human NK cell education

(2016) Vanessa Landtwing et al.   JOURNAL OF CLINICAL INVESTIGATION

NK cells and type 1 innate lymphoid cells: partners in host defense

(2016) Hergen Spits et al.   NATURE IMMUNOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

(2016) Yun Lin et al.   Immunity & Ageing

Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2–Producing Transgenic NOG Mouse

(2015) Ikumi Katano et al.   JOURNAL OF IMMUNOLOGY

Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility

(2015) Dara M. Strauss-Albee et al.   Science Translational Medicine

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

CyTOF supports efficient detection of immune cell subsets from small samples

(2014) Yi Yao et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Tissue-resident natural killer cells and their potential diversity

(2014) Dorothy K. Sojka et al.   SEMINARS IN IMMUNOLOGY

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment

(2013) T. Yamauchi et al.   BLOOD

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

Lack of CD47 Impairs Bone Cell Differentiation and Results in an Osteopenic Phenotypein Vivodue to Impaired Signal Regulatory Protein α (SIRPα) Signaling

(2013) Cecilia Koskinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice

(2012) P W Denton et al.   Mucosal Immunology

Tumor Immunotherapy Directed at PD-1

(2012) Antoni Ribas   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

(2012) Matthew B. Greenblatt et al.   PLoS One

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence

(2010) T. Strowig et al.   BLOOD

Long-Term Human CD34+ Stem Cell-Engrafted Nonobese Diabetic/SCID/IL-2R null Mice Show Impaired CD8+ T Cell Maintenance and a Functional Arrest of Immature NK Cells

(2010) M. C. Andre et al.   JOURNAL OF IMMUNOLOGY

Rituximab: Mechanism of Action

(2010) George J. Weiner   SEMINARS IN HEMATOLOGY

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets

(2009) Erwan Mortier et al.   IMMUNITY

Trans-Presentation of IL-15 by Intestinal Epithelial Cells Drives Development of CD8   IELs

(2009) L. J. Ma et al.   JOURNAL OF IMMUNOLOGY

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

(2009) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE