In vivo generated human CAR T cells eradicate tumor cells

CARs of the future

(2019) Anthony F. Daniyan et al.   AMERICAN JOURNAL OF HEMATOLOGY

Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia

(2018) Franziska Blaeschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene

(2018) Monica Casucci et al.   Frontiers in Immunology

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

(2018) Anett Pfeiffer et al.   EMBO Molecular Medicine

Extracellular Production of a Potent and Chemically Resistant Nattokinase in Immobilized Escherichia coli Using Response Surface Methodology

(2018) Fatemeh Mohammadi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Regulatory watch: European regulatory experience with advanced therapy medicinal products

(2018) Lisbeth Barkholt et al.   NATURE REVIEWS DRUG DISCOVERY

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Chimeric antigen receptor T-cells for B-cell malignancies

(2017) Eben I. Lichtman et al.   Translational Research

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

(2017) Congcong Zhang et al.   Frontiers in Immunology

Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer

(2016) Yu Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL

(2016) X. Wang et al.   BLOOD

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

(2016) Leonid Cherkassky et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Neutrophils in Measles Virus–mediated Oncolysis Differs Between B-cell Malignancies and Is Not Always Enhanced by GCSF

(2016) Aditi Dey et al.   MOLECULAR THERAPY

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

(2016) Ruben R. Bender et al.   PLoS Pathogens

T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing

(2012) Q. Zhou et al.   BLOOD