Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance

The Anti-CD19 Antibody-Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia

(2013) H. Carol et al.   CLINICAL CANCER RESEARCH

Patient-derived xenografts, the cancer stem cell paradigm and cancer pathobiology in the 21st century

(2013) Samuel A Williams et al.   LABORATORY INVESTIGATION

Passive and active DNA methylation and the interplay with genetic variation in gene regulation

(2013) Maria Gutierrez-Arcelus et al.   eLife

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

(2012) S. L. Maude et al.   BLOOD

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia

(2011) Vivek A Bhadri et al.   BMC GENOMICS

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer

(2011) Hernan Carol et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia

(2011) J Dunne et al.   LEUKEMIA

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

A Genome-Wide Study of DNA Methylation Patterns and Gene Expression Levels in Multiple Human and Chimpanzee Tissues

(2011) Athma A. Pai et al.   PLoS Genetics

Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia

(2010) Amy L Samuels et al.   BMC GENOMICS

Apoptosis and tumor resistance conferred by Par-4

(2010) Yanming Zhao et al.   CANCER BIOLOGY & THERAPY

AML1/ETO Proteins Control POU4F1/BRN3A Expression and Function in t(8;21) Acute Myeloid Leukemia

(2010) J. Dunne et al.   CANCER RESEARCH

Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines

(2010) Aabida Saferali et al.   Epigenetics

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome

(2010) Miina Ollikainen et al.   HUMAN MOLECULAR GENETICS

POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature

(2010) J M Fortier et al.   LEUKEMIA

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS