Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models

(2017) Marco Carretta et al.   EXPERIMENTAL HEMATOLOGY

Preclinical approaches in chronic myeloid leukemia: from cells to systems

(2017) Cassie J. Clarke et al.   EXPERIMENTAL HEMATOLOGY

Long-term observation reveals high-frequency engraftment of human acute myeloid leukemia in immunodeficient mice

(2017) Anna M. Paczulla et al.   HAEMATOLOGICA

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

(2017) Ander Abarrategi et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

(2017) A Elder et al.   LEUKEMIA

Preclinical modeling of myelodysplastic syndromes

(2017) K Rouault-Pierre et al.   LEUKEMIA

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

Human haematopoietic stem cell lineage commitment is a continuous process

(2017) Lars Velten et al.   NATURE CELL BIOLOGY

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

(2017) Alice Giustacchini et al.   NATURE MEDICINE

Engineering a humanized bone organ model in mice to study bone metastases

(2017) Laure C Martine et al.   Nature Protocols

Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice

(2017) Andreas Reinisch et al.   Nature Protocols

Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration

(2017) Inas El Bialy et al.   PHARMACEUTICAL RESEARCH

In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism

(2017) Yu-Ru Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration

(2017) Fiona E. Freeman et al.   TISSUE ENGINEERING PART B-REVIEWS

CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg−/− Mice Results in Severe Immunodeficiency

(2017) Xinru Wei et al.   Scientific Reports

Long-term observation reveals high-frequency engraftment of human acute myeloid leukemia in immunodeficient mice

(2017) Anna M. Paczulla et al.   HAEMATOLOGICA

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

(2017) Diana Passaro et al.   Jove-Journal of Visualized Experiments

Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development

(2017) Gretel Nusspaumer et al.   Stem Cell Reports

Titanium Coatings and Surface Modifications: Toward Clinically Useful Bioactive Implants

(2017) Ana Civantos et al.   ACS Biomaterials-Science & Engineering

Titanium Coatings and Surface Modifications: Toward Clinically Useful Bioactive Implants

(2017) Ana Civantos et al.   ACS Biomaterials Science & Engineering

Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks

(2017) Ruei-Zeng Lin et al.   Nature Biomedical Engineering

Engineering the pre-metastatic niche

(2017) Brian A. Aguado et al.   Nature Biomedical Engineering

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel–Derived Signals

(2016) Saravana K. Ramasamy et al.   Annual Review of Cell and Developmental Biology

Hematopoietic Stem Cell Niche in Health and Disease

(2016) Jonathan Hoggatt et al.   Annual Review of Pathology-Mechanisms of Disease

inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice

(2016) J. M. Ellegast et al.   BLOOD

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

(2016) Y. Saito et al.   BLOOD

Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches

(2016) A. Antonelli et al.   BLOOD

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

(2016) J. He et al.   BLOOD

JAK2V617F-mutant vascular niche contributes to JAK2V617F clonal expansion in myeloproliferative neoplasms

(2016) Chi Hua Sarah Lin et al.   BLOOD CELLS MOLECULES AND DISEASES

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

The hematopoietic stem-cell niche in health and leukemia

(2016) Abel Sánchez-Aguilera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heterogeneity of the bone marrow niche

(2016) Vionnie W.C. Yu et al.   CURRENT OPINION IN HEMATOLOGY

Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing

(2016) Sukhraj Pal S. Dhami et al.   DRUG DISCOVERY TODAY

Myelodysplastic syndrome can propagate from the multipotent progenitor compartment

(2016) Kevin Rouault-Pierre et al.   HAEMATOLOGICA

Microenvironmental cues for T-cell acute lymphoblastic leukemia development

(2016) Diana Passaro et al.   IMMUNOLOGICAL REVIEWS

Genetically distinct leukemic stem cells in human CD34−acute myeloid leukemia are arrested at a hemopoietic precursor-like stage

(2016) Lynn Quek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fine-tuning patient-derived xenograft models for precision medicine approaches in leukemia

(2016) Olivia L Francis et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model

(2016) P Sontakke et al.   LEUKEMIA

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

(2016) Andreas Reinisch et al.   NATURE MEDICINE

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice

(2016) Rituparna Das et al.   NATURE MEDICINE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myelodysplastic syndrome can propagate from the multipotent progenitor compartment

(2016) Kevin Rouault-Pierre et al.   HAEMATOLOGICA

Bone-marrow mimicking biomaterial niches for studying hematopoietic stem and progenitor cells

(2016) Michael R. Nelson et al.   Journal of Materials Chemistry B

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit Wv Mutations

(2016) Ayano Yurino et al.   Stem Cell Reports

Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels

(2015) Eamon J. Sheehy et al.   Acta Biomaterialia

Effects of in vitro chondrogenic priming time of bone-marrow-derived mesenchymal stromal cells on in vivo endochondral bone formation

(2015) Wanxun Yang et al.   Acta Biomaterialia

Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles

(2015) Jetze Visser et al.   BIOMATERIALS

Tissue engineered humanized bone supports human hematopoiesis in vivo

(2015) Boris M. Holzapfel et al.   BIOMATERIALS

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

(2015) Ji Sun Choi et al.   Biotechnology Journal

The dynamics of adult haematopoiesis in the bone and bone marrow environment

(2015) Miriel S. H. Ho et al.   BRITISH JOURNAL OF HAEMATOLOGY

Identification and Specification of the Mouse Skeletal Stem Cell

(2015) Charles K.F. Chan et al.   CELL

Three-dimensional culture and characterization of mononuclear cells from human bone marrow

(2015) Jennifer J. Bara et al.   CYTOTHERAPY

Skeletal stem cells

(2015) P. Bianco et al.   DEVELOPMENT

Expansion of mouse hematopoietic progenitor cells in three-dimensional cocultures on frozen-thawed stromal cell layers formed within porous scaffolds

(2015) Hirotoshi Miyoshi et al.   EXPERIMENTAL HEMATOLOGY

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

Prospectively Isolated Human Bone Marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells

(2015) Yoshikazu Matsuoka et al.   STEM CELLS

Concise Review: Humanized Models of Tumor Immunology in the 21st Century: Convergence of Cancer Research and Tissue Engineering

(2015) Boris Michael Holzapfel et al.   STEM CELLS

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

(2015) Syed A. Mian et al.   Nature Communications

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

(2015) Shrikanta Chattopadhyay et al.   Cell Reports

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

(2015) Ji Sun Choi et al.   Biotechnology Journal

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone

(2014) Boris M. Holzapfel et al.   BIOMATERIALS

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

(2014) A. Reinisch et al.   BLOOD

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

(2014) Petter S. Woll et al.   CANCER CELL

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

(2014) Jeffery M. Klco et al.   CANCER CELL

Bioengineered Implantable Scaffolds as a Tool to Study Stromal-Derived Factors in Metastatic Cancer Models

(2014) F. Bersani et al.   CANCER RESEARCH

Bone's dark side: mutated osteoblasts implicated in leukemia

(2014) Amir Schajnovitz et al.   CELL RESEARCH

Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier

(2014) Kadriye Nehir Cosgun et al.   Cell Stem Cell

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

NOD-scidIl2rg tm1Wjl and NOD-Rag1 null Il2rg tm1Wjl : A Model for Stromal Cell–Tumor Cell Interaction for Human Colon Cancer

(2014) Justin Maykel et al.   DIGESTIVE DISEASES AND SCIENCES

Recapitulating endochondral ossification: a promising route toin vivobone regeneration

(2014) Emmet M. Thompson et al.   Journal of Tissue Engineering and Regenerative Medicine

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen–glycosaminoglycan scaffold in vivo

(2013) T.M. McFadden et al.   Acta Biomaterialia

Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells

(2013) Annamarija Raic et al.   BIOMATERIALS

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

(2013) Kimberly A Hartwell et al.   Nature Chemical Biology

Differential regulation of myeloid leukemias by the bone marrow microenvironment

(2013) Daniela S Krause et al.   NATURE MEDICINE

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

(2013) Paolo Bianco et al.   NATURE MEDICINE

Engineering of a functional bone organ through endochondral ossification

(2013) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cells provide a niche for placental hematopoietic stem/progenitor cell expansion through broad transcriptomic modification

(2013) Christophe M. Raynaud et al.   Stem Cell Research

In Vivo Ectopic Implantation Model to Assess Human Mesenchymal Progenitor Cell Potential

(2013) Ander Abarrategi et al.   Stem Cell Reviews and Reports

Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs

(2013) Torbjorn O Pedersen et al.   Stem Cell Research & Therapy

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support

(2012) Mónica S. Ventura Ferreira et al.   BIOMATERIALS

Mechanisms of ectopic bone formation by human osteoprogenitor cells on CaP biomaterial carriers

(2012) Yoke Chin Chai et al.   BIOMATERIALS

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

(2012) R. W. J. Groen et al.   BLOOD

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

(2012) Y. Chen et al.   BLOOD

Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: Any role for Notch, Wnt and Hh signaling pathways?

(2012) Paul Faustin Seke Etet et al.   CELLULAR SIGNALLING

Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations

(2012) Klaus Rehe et al.   EMBO Molecular Medicine

Implantable microenvironments to attract hematopoietic stem/cancer cells

(2012) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of Bone Marrow Differentiation Niche: Comparative Evaluation of Different Three-Dimensional Matrices

(2012) Meghan J. Cuddihy et al.   Small

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

(2012) Teresa Mortera-Blanco et al.   Jove-Journal of Visualized Experiments

3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche

(2011) Isabelle Leisten et al.   BIOMATERIALS

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells

(2011) Eric Farrell et al.   BMC MUSCULOSKELETAL DISORDERS

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells

(2011) M. B. Sharma et al.   HAEMATOLOGICA

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

Brief Review of Models of Ectopic Bone Formation

(2011) Michelle A. Scott et al.   STEM CELLS AND DEVELOPMENT

Fibronectin coating of collagen modules increases in vivo HUVEC survival and vessel formation in SCID mice

(2010) T.P. Cooper et al.   Acta Biomaterialia

An in vivo model to study and manipulate the hematopoietic stem cell niche

(2010) J. Song et al.   BLOOD

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34- fraction

(2010) D. C. Taussig et al.   BLOOD

The association of human mesenchymal stem cells with BMP-7 improves bone regeneration of critical-size segmental bone defects in athymic rats

(2010) Giorgio Burastero et al.   BONE

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

(2010) D. Jing et al.   HAEMATOLOGICA

Rapid vascularization of starch-poly(caprolactone) in vivo by outgrowth endothelial cells in co-culture with primary osteoblasts

(2010) Shahram Ghanaati et al.   Journal of Tissue Engineering and Regenerative Medicine

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

(2010) M Wunderlich et al.   LEUKEMIA

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

(2010) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic Human Mesenchymal Stem Cell-Coated Scaffolds in NOD/SCID Mice: An In Vivo Model of the Leukemia Niche

(2010) Sarah R. Vaiselbuh et al.   TISSUE ENGINEERING PART C-METHODS

Gene expression profile on chitosan/rhBMP-2 films: A novel osteoinductive coating for implantable materials

(2009) Ander Abarrategi et al.   Acta Biomaterialia

Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering

(2009) Keun-Hong Park et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Bone-Forming Capacity of Mesenchymal Stromal Cells When Cultured in the Presence of Human Platelet Lysate as Substitute for Fetal Bovine Serum

(2009) Henk-Jan Prins et al.   TISSUE ENGINEERING PART A

Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?

(2009) Eric Farrell et al.   TISSUE ENGINEERING PART C-METHODS

In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties

(2008) Christoph le Viseur et al.   CANCER CELL

Non-obese diabetic-recombination activating gene-1 (NOD-Rag 1null) interleukin (IL)-2 receptor common gamma chain (IL 2 rγnull) null mice: a radioresistant model for human lymphohaematopoietic engraftment

(2008) T. Pearson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene

(2008) M. Seandel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo

(2008) R. Siddappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chitosan Film as rhBMP2 Carrier: Delivery Properties for Bone Tissue Application

(2007) Ander Abarrategi et al.   BIOMACROMOLECULES