Bridging the gaps to overcome major hurdles in the development of next-generation tuberculosis vaccines

Immunological aspects of host–pathogen crosstalk in the co-pathogenesis of diabetes and latent tuberculosis

(2023) Arpana Verma et al.   Frontiers in Cellular and Infection Microbiology

Disease Duration and Chronic Complications Associate With Immune Activation in Individuals With Longstanding Type 1 Diabetes

(2023) Mandala Ajie et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity

(2023) Judith Schick et al.   eLife

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

(2022) Arianne Lovey et al.   Nature Communications

Risk of Second Allergic Reaction to SARS-CoV-2 Vaccines

(2022) Derek K. Chu et al.   JAMA Internal Medicine

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

(2022) Irene Pérez et al.   Molecular Therapy-Nucleic Acids

Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans

(2022) Mangalakumari Jeyanathan et al.   JCI Insight

Aerosolization of Mycobacterium tuberculosis by Tidal Breathing

(2022) Ryan Dinkele et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-tuberculosis treatment strategies and drug development: challenges and priorities

(2022) Véronique A. Dartois et al.   NATURE REVIEWS MICROBIOLOGY

Enhanced immunogenicity of the tuberculosis subunit Rv0572c vaccine delivered in DMT liposome adjuvant as a BCG-booster

(2022) Lirong Mao et al.   TUBERCULOSIS

Utility of urinary cytokine levels as predictors of the immunogenicity and reactogenicity of AS01-adjuvanted hepatitis B vaccine in healthy adults

(2022) Wivine Burny et al.   VACCINE

Optimizing the Boosting Schedule of Subunit Vaccines Consisting of BCG and “Non-BCG” Antigens to Induce Long-Term Immune Memory

(2022) Wei Lv et al.   Frontiers in Immunology

Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial

(2022) Mark F Cotton et al.   LANCET INFECTIOUS DISEASES

Incidence, risk factors, natural history, and hypothesised mechanisms of myocarditis and pericarditis following covid-19 vaccination: living evidence syntheses and review

(2022) Jennifer Pillay et al.   BMJ-British Medical Journal

Research Advances for Virus-vectored Tuberculosis Vaccines and Latest Findings on Tuberculosis Vaccine Development

(2022) Zhidong Hu et al.   Frontiers in Immunology

ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at Risk

(2022) Maria Tsilika et al.   Frontiers in Immunology

End-point definition and trial design to advance tuberculosis vaccine development

(2022) Alberto L. Garcia-Basteiro et al.   European Respiratory Review

Recall responses in the lung environment are impacted by age in a pilot study of Mycobacterium bovis-BCG vaccinated rhesus macaques

(2022) Julia M. Scordo et al.   EXPERIMENTAL GERONTOLOGY

Challenges in TB research

(2022) Thomas J. Scriba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

100 Years of BCG Immunization: Past, Present, and Future

(2022) Aldo Tagliabue et al.   Vaccines

Paving the way to a new class of efficient and safe tuberculosis vaccines: The role of c-di-AMP in Mycobacterium tuberculosis immunity and virulence

(2022) Mohamed E. El Zowalaty et al.   Molecular Therapy-Nucleic Acids

Editorial: Beyond Th1: Novel concepts in tuberculosis vaccine immunology

(2022) Karin Dijkman et al.   Frontiers in Immunology

COVID-19 and the human innate immune system

(2021) Joachim L. Schultze et al.   CELL

Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery

(2021) Cristina C. Clement et al.   IMMUNITY

Subunit Vaccine ESAT-6:c-di-AMP Delivered by Intranasal Route Elicits Immune Responses and Protects Against Mycobacterium tuberculosis Infection

(2021) Huanhuan Ning et al.   Frontiers in Cellular and Infection Microbiology

Applications of Transcriptomics and Proteomics for Understanding Dormancy and Resuscitation in Mycobacterium tuberculosis

(2021) Manikuntala Kundu et al.   Frontiers in Microbiology

Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals

(2021) Julia M. Scordo et al.   Immunity & Ageing

Balance between Protection and Pathogenic Response to Aerosol Challenge with Mycobacterium tuberculosis (Mtb) in Mice Vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens

(2021) Sadaf Sulman et al.   Vaccines

Mucosal Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens Provides Protection against Mycobacterium tuberculosis in Mice and Guinea Pigs

(2021) Mariia Sergeeva et al.   Vaccines

The monocyte-to-lymphocyte ratio: Sex-specific differences in the tuberculosis disease spectrum, diagnostic indices and defining normal ranges

(2021) Thomas S. Buttle et al.   PLoS One

Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

(2021) Michel de Jesús Aceves-Sánchez et al.   Scientific Reports

Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice

(2021) Hao Gu et al.   eLife

Effect of BCG vaccination on proinflammatory responses in elderly individuals

(2021) Nathella Pavan Kumar et al.   Science Advances

A Dendritic Cell-Activating Rv1876 Protein Elicits Mycobacterium Bovis BCG-Prime Effect via Th1-Immune Response

(2021) Seunga Choi et al.   Biomolecules

Diabetes Status and Association With Risk of Tuberculosis Among Korean Adults

(2021) Jung Eun Yoo et al.   JAMA Network Open

Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques

(2021) Edward B. Irvine et al.   NATURE IMMUNOLOGY

A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

(2021) Joshua S. Woodworth et al.   Nature Communications

A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients

(2021) Synne Jenum et al.   Nature Communications

Cytomegalovirus acquisition in infancy and the risk of tuberculosis disease in childhood: a longitudinal birth cohort study in Cape Town, South Africa

(2021) Leonardo Martinez et al.   Lancet Global Health

Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis

(2021) Elena Mata et al.   Science Immunology

Enhancement of the Local CD8+ T-Cellular Immune Response to Mycobacterium tuberculosis in BCG-Primed Mice after Intranasal Administration of Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens

(2021) Kirill Vasilyev et al.   Vaccines

Prevention of tuberculosis in macaques after intravenous BCG immunization

(2020) Patricia A. Darrah et al.   NATURE

Intranasal vaccination with Listeria ivanovii as vector of Mycobacterium tuberculosis antigens promotes specific lung-localized cellular and humoral immune responses

(2020) Ming-juan Jiang et al.   Scientific Reports

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

(2020) Carla B. Roces et al.   Vaccines

Can blocking inflammation enhance immunity during aging?

(2020) Emma S. Chambers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: Characterization of Human Tissue-Resident Memory T Cells at Different Infection Sites in Patients with Tuberculosis

(2020) Qianting Yang et al.   JOURNAL OF IMMUNOLOGY

Towards new TB vaccines

(2020) Benedict Brazier et al.   Seminars in Immunopathology

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

(2020) Pierre Bourdely et al.   IMMUNITY

Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis

(2020) Thomas E. Bickett et al.   Frontiers in Immunology

Mycobacterium tuberculosis Rv2005c Induces Dendritic Cell Maturation and Th1 Responses and Exhibits Immunotherapeutic Activity by Fusion with the Rv2882c Protein

(2020) Yong Woo Back et al.   Vaccines

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

(2020) Evangelos J. Giamarellos-Bourboulis et al.   CELL

A Systemic Prime–Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection

(2020) Qian He et al.   Frontiers in Immunology

Vaccine strategies for the Mtb/HIV copandemic

(2020) Riti Sharan et al.   npj Vaccines

Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis

(2020) Courtney R. Plumlee et al.   Cell Host & Microbe

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

(2020) Toshiro Hirai et al.   IMMUNITY

Systematic evaluation of Mycobacterium tuberculosis proteins for antigenic properties identifies Rv1485 and Rv1705c as potential protective subunit vaccine candidates

(2020) Yaguo Wang et al.   INFECTION AND IMMUNITY

Proteomic characterization of a second-generation version of the BCGΔBCG1419c vaccine candidate by means of electrospray-ionization quadrupole time-of-flight mass spectrometry

(2020) Jesús Bernardino Velázquez-Fernández et al.   Pathogens and Disease

Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial

(2020) Tracey A Day et al.   Lancet Respiratory Medicine

A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells

(2019) Nicolas Çuburu et al.   JOURNAL OF IMMUNOLOGY

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

(2019) Karin Dijkman et al.   NATURE MEDICINE

Successful application of prime and pull strategy for a therapeutic HSV vaccine

(2019) David I. Bernstein et al.   npj Vaccines

Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo

(2019) Alissa C. Rothchild et al.   Science Immunology

Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial

(2019) Michele Tameris et al.   Lancet Respiratory Medicine

Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells

(2019) Siamak Haddadi et al.   Frontiers in Immunology

Changes of urine metabolite profiles are induced by inactivated influenza vaccine inoculations in mice

(2019) Eita Sasaki et al.   Scientific Reports

First-In-Human Trials of GamTBvac, a Recombinant Subunit Tuberculosis Vaccine Candidate: Safety and Immunogenicity Assessment

(2019) Vasina et al.   Vaccines

Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis

(2019) Dereck R. Tait et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis

(2019) Florence Levillain et al.   VACCINE

Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis

(2018) Song Yee Kim et al.   BMC INFECTIOUS DISEASES

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine

(2018) Elena Stylianou et al.   INFECTION AND IMMUNITY

Does BCG Vaccination Protect Against Nontuberculous Mycobacterial Infection? A Systematic Review and Meta-Analysis

(2018) Petra Zimmermann et al.   JOURNAL OF INFECTIOUS DISEASES

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

(2018) Scott G Hansen et al.   NATURE MEDICINE

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

(2018) Elisa Nemes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial

(2018) Adam Penn-Nicholson et al.   Lancet Respiratory Medicine

Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells

(2018) Shiki Takamura   Frontiers in Immunology

Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults

(2018) Robert A. van den Berg et al.   Frontiers in Immunology

Formulation in DDA-MPLA-TDB Liposome Enhances the Immunogenicity and Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection

(2018) Maopeng Tian et al.   Frontiers in Immunology

Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses

(2018) Lis Noelia Velasquez et al.   Frontiers in Immunology

The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial

(2018) Rhea N. Coler et al.   npj Vaccines

Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis

(2018) Olivier Van Der Meeren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of tuberculosis vaccines in clinical trials: Current status

(2018) Patricia Méndez-Samperio   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Long-term safety and immunogenicity of the M72/AS01E candidate tuberculosis vaccine in HIV-positive and -negative Indian adults

(2018) Nagalingeswaran Kumarasamy et al.   MEDICINE

A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis

(2018) Marjorie Z. Imperial et al.   NATURE MEDICINE

Elucidation of a Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy

(2018) Bryna L. Fitzgerald et al.   ACS Infectious Diseases

Immunogenicity and protective efficacy of multistage vaccine candidates (Mtb8.4-HspX and HspX-Mtb8.4) against Mycobacterium tuberculosis infection in mice

(2017) Wanbo Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PO and ID BCG vaccination in humans induce distinct mucosal and systemic immune responses and CD4+ T cell transcriptomal molecular signatures

(2017) D F Hoft et al.   Mucosal Immunology

Latently and uninfected healthcare workers exposed to TB make protective antibodies againstMycobacterium tuberculosis

(2017) Hao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rv2299c, a novel dendritic cell-activating antigen of Mycobacterium tuberculosis, fused-ESAT-6 subunit vaccine confers improved and durable protection against the hypervirulent strain HN878 in mice

(2017) Han-Gyu Choi et al.   Oncotarget

Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K

(2017) Kee Woong Kwon et al.   Scientific Reports

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

(2017) Matthias I. Gröschel et al.   Cell Reports

IFN-α Boosting of Mycobacterium bovis Bacillus Calmette Güerin-Vaccine Promoted Th1 Type Cellular Response and Protection against M. tuberculosis Infection

(2017) C. E. Rivas-Santiago et al.   Biomed Research International

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

(2017) Alexander G. White et al.   Jove-Journal of Visualized Experiments

A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells

(2017) Qi Yu et al.   Frontiers in Immunology

Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection

(2017) Claudio Counoupas et al.   Scientific Reports

Disseminated tuberculosis among hospitalised HIV patients in South Africa: a common condition that can be rapidly diagnosed using urine-based assays

(2017) Andrew D. Kerkhoff et al.   Scientific Reports

A Functional Role for Antibodies in Tuberculosis

(2016) Lenette L. Lu et al.   CELL

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa

(2016) André G. Loxton et al.   Clinical and Vaccine Immunology

Immunogenicity and Therapeutic Effects of pVAX1-rv1419 DNA from Mycobacterium tuberculosis

(2016) Yan Liang et al.   CURRENT GENE THERAPY

Human isotype‐dependent inhibitory antibody responses against Mycobacterium tuberculosis

(2016) Natalie Zimmermann et al.   EMBO Molecular Medicine

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis

(2016) Yangjiong Xiao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Fc-based delivery system enhances immunogenicity of a tuberculosis subunit vaccine candidate consisting of the ESAT-6:CFP-10 complex

(2016) Hadi Farsiani et al.   Molecular BioSystems

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

(2016) D Christensen et al.   Mucosal Immunology

Safety and immunogenicity of the M72/AS01 E candidate tuberculosis vaccine in adults with tuberculosis: A phase II randomised study

(2016) Paul Gillard et al.   TUBERCULOSIS

Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis

(2016) Carolina Perdomo et al.   mBio

Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype

(2016) Clare M. Smith et al.   mBio

Ag85B synergizes with ESAT-6 to induce efficient and long-term immunity of C57BL/6 mice primed with recombinant Bacille Calmette-Guerin

(2016) Wei Liu et al.   Experimental and Therapeutic Medicine

T-cell activation is an immune correlate of risk in BCG vaccinated infants

(2016) Helen A. Fletcher et al.   Nature Communications

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

(2016) Kristin L. Griffiths et al.   Nature Communications

Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity

(2016) Jilei Ma et al.   Oncotarget

A multistage mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis

(2016) Xun Liu et al.   Human Vaccines & Immunotherapeutics

The Role of Neutrophils in the Induction of Specific Th1 and Th17 during Vaccination against Tuberculosis

(2016) Monalisa M. Trentini et al.   Frontiers in Microbiology

Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial

(2016) Daniel F. Hoft et al.   EBioMedicine

Child survival and BCG vaccination: a community based prospective cohort study in Uganda

(2015) Victoria Nankabirwa et al.   BMC PUBLIC HEALTH

Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis

(2015) Mariateresa Coppola et al.   Clinical and Vaccine Immunology

Recombinant tuberculosis vaccine AEC/BC02 induces antigen-specific cellular responses in mice and protects guinea pigs in a model of latent infection

(2015) Jin-biao Lu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Enhanced and durable protective immune responses induced by a cocktail of recombinant BCG strains expressing antigens of multistage of Mycobacterium tuberculosis

(2015) Jinping Liang et al.   MOLECULAR IMMUNOLOGY

Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge

(2015) L Monin et al.   Mucosal Immunology

ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis

(2015) Aarón Silva-Sánchez et al.   PLoS One

Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies

(2015) Igor Kramnik et al.   Seminars in Immunopathology

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system

(2015) Daria Bottai et al.   VACCINE

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

(2015) Angelique Kany Kany Luabeya et al.   VACCINE

Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting

(2015) Adam Penn-Nicholson et al.   VACCINE

Parsimonious Determination of the Optimal Infectious Dose of a Pathogen for Nonhuman Primate Models

(2015) Mario Roederer   PLoS Pathogens

Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial

(2015) Birahim Pierre Ndiaye et al.   Lancet Respiratory Medicine

Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial

(2015) François Spertini et al.   Lancet Respiratory Medicine

Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

(2015) Hongxia Niu et al.   PLoS One

Use of Resuscitation-Promoting Factor Proteins Improves the Sensitivity of Culture-based Tuberculosis Testing in Special Samples

(2014) Wei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Monkey Models of Tuberculosis: Lessons Learned

(2014) Juliet C. Peña et al.   INFECTION AND IMMUNITY

Brief Report

(2014) Vivek Naranbhai et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Immune Subdominant Antigens as Vaccine Candidates againstMycobacterium tuberculosis

(2014) Mark T. Orr et al.   JOURNAL OF IMMUNOLOGY

Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-DoseMycobacterium tuberculosisChallenge

(2014) Patricia A. Darrah et al.   JOURNAL OF IMMUNOLOGY

Oral bacillus Calmette-Guérin vaccine against tuberculosis: why not?

(2014) Renata Monteiro-Maia et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Exploration of Novel Cellular and Serological Antigen Biomarkers in the ORFeome ofMycobacterium tuberculosis

(2014) Liguo Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

In search of a new paradigm for protective immunity to TB

(2014) Cláudio Nunes-Alves et al.   NATURE REVIEWS MICROBIOLOGY

The Effect of Maternal Helminth Infection on Maternal and Neonatal Immune Function and Immunity to Tuberculosis

(2014) Dawit Gebreegziabiher et al.   PLoS One

A New Recombinant BCG Vaccine Induces Specific Th17 and Th1 Effector Cells with Higher Protective Efficacy against Tuberculosis

(2014) Adeliane Castro da Costa et al.   PLoS One

Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics

(2014) N. P. H. Knudsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countries

(2014) G. M. Knight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis

(2014) Hazel C. Poyntz et al.   TUBERCULOSIS

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4+ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs

(2014) Susanna Commandeur et al.   VACCINE

Sequence Diversity in the pe_pgrs Genes of Mycobacterium tuberculosis Is Independent of Human T Cell Recognition

(2014) R. Copin et al.   mBio

Development of an Unbiased Antigen-Mining Approach To Identify Novel Vaccine Antigens and Diagnostic Reagents for Bovine Tuberculosis

(2013) Gareth J. Jones et al.   Clinical and Vaccine Immunology

Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials

(2013) Punam Mangtani et al.   CLINICAL INFECTIOUS DISEASES

A Randomized, Controlled Dose-Finding Phase II Study of the M72/AS01 Candidate Tuberculosis Vaccine in Healthy PPD-Positive Adults

(2013) Jaime Montoya et al.   JOURNAL OF CLINICAL IMMUNOLOGY

CXCR5+ T helper cells mediate protective immunity against tuberculosis

(2013) Samantha R. Slight et al.   JOURNAL OF CLINICAL INVESTIGATION

Ratio of Monocytes to Lymphocytes in Peripheral Blood Identifies Adults at Risk of Incident Tuberculosis Among HIV-Infected Adults Initiating Antiretroviral Therapy

(2013) Vivek Naranbhai et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

(2013) Michele D Tameris et al.   LANCET

Putative roles of a proline–glutamic acid-rich protein (PE3) in intracellular survival and as a candidate for subunit vaccine against Mycobacterium tuberculosis

(2013) Susmita K. Singh et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

Subunit Vaccine Consisting of Multi-Stage Antigens Has High Protective Efficacy against Mycobacterium tuberculosis Infection in Mice

(2013) Qi Xin et al.   PLoS One

Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in a phase 1 open-label randomized clinical trial

(2013) Leander Grode et al.   VACCINE

Variability of Infectious Aerosols Produced during Coughing by Patients with Pulmonary Tuberculosis

(2012) Kevin P. Fennelly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Phase IIa Trial of the New Tuberculosis Vaccine, MVA85A, in HIV- and/orMycobacterium tuberculosis–infected Adults

(2012) Thomas J. Scriba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective and survival efficacies of Rv0160c protein in murine model of Mycobacterium tuberculosis

(2012) Susmita K. Singh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Human Cytomegalovirus Infant Infection Adversely Affects Growth and Development in Maternally HIV-Exposed and Unexposed Infants in Zambia

(2012) U. A. Gompels et al.   CLINICAL INFECTIOUS DISEASES

NK1.1+ Cells and IL-22 Regulate Vaccine-Induced Protective Immunity against Challenge with Mycobacterium tuberculosis

(2012) R. Dhiman et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Immunization against Mycobacterium tuberculosis Is an Effective Adjunct to Antibiotic Treatment

(2012) Rhea N. Coler et al.   JOURNAL OF INFECTIOUS DISEASES

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberculosis Vaccines: A Strategic Blueprint for the Next Decade

(2012) Michael J. Brennan et al.   TUBERCULOSIS

Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis

(2012) Michael J. Brennan et al.   VACCINE

Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: A randomized trial

(2012) Isabel Leroux-Roels et al.   VACCINE

The Pathology of Mycobacterium tuberculosis Infection

(2012) K. Sakamoto   VETERINARY PATHOLOGY

The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection

(2011) Philana Ling Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung

(2011) Shabaana A. Khader et al.   JOURNAL OF IMMUNOLOGY

Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines

(2011) M. Romano et al.   MICROBES AND INFECTION

A multistage tuberculosis vaccine that confers efficient protection before and after exposure

(2011) Claus Aagaard et al.   NATURE MEDICINE

Immunogenicity and Protective Efficacy of a Fusion Protein Vaccine Consisting of Antigen Ag85B and HspX against Mycobacterium tuberculosis Infection in Mice

(2011) Q. Li et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10.4–HspX

(2011) Hongxia Niu et al.   VACCINE

IP-10 detection in urine is associated with lung diseases

(2010) Angela Cannas et al.   BMC INFECTIOUS DISEASES

Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing

(2010) S. A. Sharpe et al.   Clinical and Vaccine Immunology

Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection

(2010) Nadia Caccamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Production and Characterization of Monoclonal Antibody Against Mycobacterium tuberculosis RpfB Domain

(2010) Ailin Fan et al.   HYBRIDOMA

Recombinant BCG-Rv1767 amount determines, in vivo, antigen-specific T cells location, frequency, and protective outcome

(2010) Viviana Speranza et al.   MICROBIAL PATHOGENESIS

Comparative expression analysis of rpf-like genes of Mycobacterium tuberculosis H37Rv under different physiological stress and growth conditions

(2010) R. K. Gupta et al.   MICROBIOLOGY-SGM

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

(2010) Iñaki Comas et al.   NATURE GENETICS

Host Genetics in Granuloma Formation: Human-Like Lung Pathology in Mice with Reciprocal Genetic Susceptibility to M. tuberculosis and M. avium

(2010) Elena Kondratieva et al.   PLoS One

A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis

(2010) S. Bertholet et al.   Science Translational Medicine

Oral delivery of BCG Moreau Rio de Janeiro gives equivalent protection against tuberculosis but with reduced pathology compared to parenteral BCG Danish vaccination

(2010) Simon O. Clark et al.   VACCINE

Resuscitation-promoting Factors Reveal an Occult Population of Tubercle Bacilli in Sputum

(2009) Galina V. Mukamolova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection

(2009) Jonathan K. Nambiar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pattern and diversity of cytokine production differentiates betweenMycobacterium tuberculosisinfection and disease

(2009) Jayne S. Sutherland et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection

(2009) Sebastian D. Schuck et al.   PLoS One

MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

(2009) Frank A. W. Verreck et al.   PLoS One

Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production

(2008) Daniel Elias et al.   VACCINE

Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum

(2008) Natalie J Garton et al.   PLOS MEDICINE