Obeticholic acid treatment of mice to promote fertilization and reproduction

Mechanisms & Molecules: What are the treatment targets for PBC?

(2022) Marlyn J Mayo   HEPATOLOGY

Biosolids: The Trojan horse or the beautiful Helen for soil fertilization?

(2022) A.E. Kanteraki et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Integrated organic and inorganic fertilization and reduced irrigation altered prokaryotic microbial community and diversity in different compartments of wheat root zone contributing to improved nitrogen uptake and wheat yield

(2022) Chao Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

What is missing to advance foliar fertilization using nanotechnology?

(2022) Søren Husted et al.   TRENDS IN PLANT SCIENCE

Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis

(2022) Kuei-Chuan Lee et al.   Clinical and Molecular Hepatology

Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion

(2021) Norman B. Javitt   JOURNAL OF HEPATOLOGY

Influences of irrigation and fertilization on soil N cycle and losses from wheat–maize cropping system in northern China

(2021) Xin Zhang et al.   ENVIRONMENTAL POLLUTION

Obeticholic Acid Inhibits Anxiety via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice

(2021) Li Wu et al.   Nutrients

A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage

(2021) Suling Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obeticholic acid for the treatment of nonalcoholic steatohepatitis: Expectations and concerns

(2020) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obeticholic acid ameliorates Valproic acid-induced Hepatic Steatosis and Oxidative Stress

(2020) Zhibo Gai et al.   MOLECULAR PHARMACOLOGY

Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia

(2020) Vanessa Pataia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by down-regulating the renal 8-iso-PGF2α-activated COX-TXA2 pathway

(2020) Yu-Lien Tsai et al.   CLINICAL SCIENCE

The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice

(2020) Cheng Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Obeticholic acid protects against diabetic cardiomyopathy by activation of FXR/Nrf2 signaling in db/db mice

(2019) Hongkui Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Analysis of exposure margins in developmental toxicity studies for detection of human teratogens

(2019) Paul A. Andrews et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Post‐ejaculatory modifications to sperm (PEMS)

(2019) Scott Pitnick et al.   BIOLOGICAL REVIEWS

Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

(2019) Wei Chen et al.   Oxidative Medicine and Cellular Longevity

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Primary biliary cholangitis: pathogenesis and therapeutic opportunities

(2019) Aliya F. Gulamhusein et al.   Nature Reviews Gastroenterology & Hepatology

Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression

(2018) O. Erice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines

(2018) Gideon M Hirschfield et al.   GUT

Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation

(2018) Jean Damascene Niringiyumukiza et al.   Reproductive Biology and Endocrinology

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

(2018) Antonella Borrelli et al.   Redox Biology

Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis

(2018) Jiyu Zhou et al.   Acta Pharmaceutica Sinica B

Developmental and reproductive toxicological evaluation of arachidonic acid (ARA)-Rich oil and docosahexaenoic acid (DHA)-Rich oil

(2017) Michael C. Falk et al.   FOOD AND CHEMICAL TOXICOLOGY

Importance of sperm morphology during their transport and fertilization in mammals

(2016) FranciscoA García-Vázquez et al.   ASIAN JOURNAL OF ANDROLOGY

Obeticholic Acid: First Global Approval

(2016) A. Markham et al.   DRUGS

Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity

(2016) Yuan-Hua Chen et al.   JOURNAL OF IMMUNOLOGY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice

(2016) Fahrettin Haczeyni et al.   Obesity

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Hit or Miss: Fertilization Outcomes of Natural Inseminations by Japanese Quail

(2015) Elizabeth Adkins-Regan   PLoS One

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'

(2009) C. L. Borg et al.   HUMAN REPRODUCTION UPDATE