Obeticholic Acid Inhibits Anxiety via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice

Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis

(2020) Leonardo Silva de Araujo et al.   Journal of Translational Medicine

Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients

(2020) Nicte Alaide Ramos-García et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

(2020) Pavan Bhargava et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of bacterial lipopolysaccharide-induced sickness behavior in rodents and humans: relevance for symptoms of anxiety and depression

(2020) Julie Lasselin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Physical activity reduces anxiety and regulates brain fatty acid synthesis

(2020) Arkadiusz Liśkiewicz et al.   Molecular Brain

Host–microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling

(2020) Ning Ma et al.   Gut Microbes

The gut microbiota and mental health in adults

(2020) Ellionore Järbrink-Sehgal et al.   CURRENT OPINION IN NEUROBIOLOGY

Anxiogenic-like effect of chronic lipopolysaccharide is associated with increased expression of matrix metalloproteinase 9 in the rat amygdala

(2020) Galina T. Shishkina et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Bile Acids: A Communication Channel in the Gut-Brain Axis

(2020) Vera F. Monteiro-Cardoso et al.   NEUROMOLECULAR MEDICINE

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

(2020) Yajun Qiao et al.   Annals of Translational Medicine

Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala

(2020) Zhi-Heng Zheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice

(2019) Fan Yu et al.   Aging-US

Bile Acids as Metabolic Regulators and Nutrient Sensors

(2019) John Y. L. Chiang et al.   Annual Review of Nutrition

Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort

(2019) Ping Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome

(2019) Marcus Boehme et al.   MOLECULAR PSYCHIATRY

Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats

(2019) Darakhshan Jabeen Haleem et al.   NUTRITIONAL NEUROSCIENCE

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice

(2019) Yuqiu Han et al.   Frontiers of Medicine

Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila

(2019) Youjun Yang et al.   NEUROPSYCHOPHARMACOLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

(2019) Ke-qi Fan et al.   CELL

Urinary metabolomics reveals kynurenine pathway perturbation in newborns with transposition of great arteries after surgical repair

(2019) Manuela Simonato et al.   Metabolomics

Plasma phospholipid profiling of a mouse model of anxiety disorder by hydrophilic interaction liquid chromatography coupled to high-resolution mass spectrometry

(2018) Róbert Berkecz et al.   BIOMEDICAL CHROMATOGRAPHY

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

FXR Acts as a Metastasis Suppressor in Intrahepatic Cholangiocarcinoma by Inhibiting IL-6-Induced Epithelial-Mesenchymal Transition

(2018) Bei Lv et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulation of proinflammatory monocyte activation by the kynurenine–AhR axis underlies immunometabolic control of depressive behavior in mice

(2018) Xiaojie Zang et al.   FASEB JOURNAL

Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder

(2018) Ebrahim Haroon et al.   PSYCHONEUROENDOCRINOLOGY

Intermittent low-level lead exposure provokes anxiety, hypertension, autonomic dysfunction and neuroinflammation

(2018) Liana Shvachiy et al.   NEUROTOXICOLOGY

Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels

(2018) Jianzhong Ye et al.   Frontiers in Microbiology

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

(2018) Elliot S. Friedman et al.   GASTROENTEROLOGY

Prenatal Programming of Neuroendocrine System Development by Lipopolysaccharide: Long-Term Effects

(2018) Marina Izvolskaia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The gut microbiota at the intersection of diet and human health

(2018) Christopher L. Gentile et al.   SCIENCE

Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

(2018) Guoxiang Xie et al.   EBioMedicine

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction

(2017) Shi-Yi Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis

(2017) Silvia Rossi et al.   NEUROLOGY

Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice

(2017) Matthew McMillin et al.   Frontiers in Cellular Neuroscience

The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

(2017) Fenglei Li et al.   Nature Communications

Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl4-induced liver cirrhosis by protecting the intestinal barrier in rats

(2017) Ding Shi et al.   Scientific Reports

A Fatty Acids Mixture Reduces Anxiety-Like Behaviors in Infant Rats Mediated by GABAA Receptors

(2017) Blandina Bernal-Morales et al.   Biomed Research International

Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model

(2017) Wenrui Wu et al.   Frontiers in Microbiology

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2016) Ana L. Gomes et al.   CANCER CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anxiety

(2016) Michelle G Craske et al.   LANCET

Impaired fear extinction retention and increased anxiety-like behaviours induced by limited daily access to a high-fat/high-sugar diet in male rats: Implications for diet-induced prefrontal cortex dysregulation

(2016) Kathryn D. Baker et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis

(2016) Peggy P. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixture of Peanut Skin Extract and Fish Oil Improves Memory in Mice via Modulation of Anti-Oxidative Stress and Regulation of BDNF/ERK/CREB Signaling Pathways

(2016) Lan Xiang et al.   Nutrients

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

(2015) Juliane Zemdegs et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia

(2015) Yi-Hsuan Lee et al.   GLIA

S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease

(2015) Maite Martínez-Uña et al.   JOURNAL OF HEPATOLOGY

Constructs of depression and distress in diabetes: time for an appraisal

(2015) Frank J Snoek et al.   Lancet Diabetes & Endocrinology

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

(2014) Matthew Quinn et al.   DIGESTIVE AND LIVER DISEASE

Rapid regression of atherosclerosis with MTP inhibitor treatment

(2013) Bernd Hewing et al.   ATHEROSCLEROSIS

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

(2013) Q. Huang et al.   CANCER RESEARCH

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

(2013) Morgan G I Langille et al.   NATURE BIOTECHNOLOGY

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

(2012) Ayşe Demirkan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Global prevalence of anxiety disorders: a systematic review and meta-regression

(2012) A. J. Baxter et al.   PSYCHOLOGICAL MEDICINE

Fecal metabolome profiling of liver cirrhosis and hepatocellular carcinoma patients by ultra performance liquid chromatography–mass spectrometry

(2011) Hongcui Cao et al.   ANALYTICA CHIMICA ACTA

Effects of opioidergic systems upon anxiolytic-like behaviors induced in cholestatic rats

(2011) Delaram Eslimi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabonomic Profiles Discriminate Hepatocellular Carcinoma from Liver Cirrhosis by Ultraperformance Liquid Chromatography–Mass Spectrometry

(2011) Baohong Wang et al.   JOURNAL OF PROTEOME RESEARCH

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis

(2009) Koji Fujita et al.   HEPATOLOGY

Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals

(2009) Chris Pickering et al.   PSYCHOPHARMACOLOGY

Late-Life Anxiety and Cognitive Impairment: A Review

(2008) Sherry A. Beaudreau et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES