Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by down-regulating the renal 8-iso-PGF2α-activated COX-TXA2 pathway

Incidence, Risk Factors, and Outcomes of Transition of Acute Kidney Injury to Chronic Kidney Disease in Cirrhosis: A Prospective Cohort Study

(2019) Rakhi Maiwall et al.   HEPATOLOGY

News in Pathophysiology, Definition and Classification of Hepatorenal Syndrome: a step beyond the International Club of Ascites (ICA) Consensus document

(2019) Paolo Angeli et al.   JOURNAL OF HEPATOLOGY

FxR-modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

(2019) M. Sorribas et al.   JOURNAL OF HEPATOLOGY

New Developments in Hepatorenal Syndrome

(2018) Ayse L. Mindikoglu et al.   Clinical Gastroenterology and Hepatology

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

(2018) Romeo Papazyan et al.   JOURNAL OF LIPID RESEARCH

Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis

(2018) Michael M Yeboah et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Farnesoid X receptor agonist obeticholic acid inhibits renal inflammation and oxidative stress during lipopolysaccharide-induced acute kidney injury

(2018) Jin-Bo Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Serum adrenomedullin and urinary thromboxane B2 help early categorizing of acute kidney injury in decompensated cirrhotic patients: A prospective cohort study

(2017) Chih-Wei Liu et al.   HEPATOLOGY RESEARCH

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

(2017) Philipp Schwabl et al.   JOURNAL OF HEPATOLOGY

Sulfasalazine induces mitochondrial dysfunction and renal injury

(2017) Hossein Niknahad et al.   RENAL FAILURE

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage

(2017) Zhibo Gai et al.   Scientific Reports

Differential visceral blood flow in the hyperdynamic circulation of patients with liver cirrhosis

(2016) N. C. McAvoy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pathogenesis of Hepatorenal Syndrome: Implications for Therapy

(2016) François Durand et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice

(2015) Zhibo Gai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X receptor agonist CDCA reduces blood pressure and regulates vascular tone in spontaneously hypertensive rats

(2015) Chenyu Li et al.   Journal of the American Society of Hypertension

Treatment of type 2 hepatorenal syndrome in patients awaiting transplantation: Effects on kidney function and transplantation outcomes

(2015) Ezequiel Rodriguez et al.   LIVER TRANSPLANTATION

Farnesoid X Receptor Antagonizes JNK Signaling Pathway in Liver Carcinogenesis by ActivatingSOD3

(2015) Yan-Dong Wang et al.   MOLECULAR ENDOCRINOLOGY

The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice

(2014) F.A.R. Lívero et al.   CHEMICO-BIOLOGICAL INTERACTIONS

N-acetylcysteine reduces oxidative stress, nuclear factor-κB activity and cardiomyocyte apoptosis in heart failure

(2014) XIAO-YAN WU et al.   Molecular Medicine Reports

Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats

(2013) Eugenio Rosado et al.   HEPATOLOGY

Platelet Isoprostane Overproduction in Diabetic Patients Treated With Aspirin

(2012) R. Cangemi et al.   DIABETES

Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats

(2012) Zhijuan Hu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Inherited Human gp91 phox Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction

(2010) Pasquale Pignatelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Farnesoid X Receptor Activation Prevents the Development of Vascular Calcification in ApoE −/− Mice With Chronic Kidney Disease

(2010) Shinobu Miyazaki-Anzai et al.   CIRCULATION RESEARCH

Mechanisms of TNFα-induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNFα and endocannabinoids

(2010) Ying-Ying Yang et al.   JOURNAL OF HEPATOLOGY

Increased flow-mediated vasodilation in cirrhotic patients with ascites: relationship with renal resistive index

(2010) Massimo Cazzaniga et al.   LIVER INTERNATIONAL

Hypoxia-induced hyperreactivity of pulmonary arteries: role of cyclooxygenase-2, isoprostanes, and thromboxane receptors

(2009) E. Delannoy et al.   CARDIOVASCULAR RESEARCH

Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients

(2008) S. Cottone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Development of hepatorenal syndrome in bile duct ligated rats

(2008) Regina M Pereira et al.   WORLD JOURNAL OF GASTROENTEROLOGY