Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

(2019) Caroline Ovadia et al.   LANCET

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis

(2019) Caroline Ovadia et al.   HEPATOLOGY

Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in a mouse model of gestational diabetes

(2019) Saraid McIlvride et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial

(2019) Lucy C Chappell et al.   LANCET

Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

(2019) Wei Chen et al.   Oxidative Medicine and Cellular Longevity

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota

(2018) Julie A.K. McDonald et al.   GASTROENTEROLOGY

Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease

(2018) Benjamin H. Mullish et al.   METHODS

Bile acids and gestation

(2017) Saraid McIlvride et al.   MOLECULAR ASPECTS OF MEDICINE

Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers

(2016) R. Pencek et al.   DIABETES OBESITY & METABOLISM

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats

(2016) María Úbeda et al.   JOURNAL OF HEPATOLOGY

Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy

(2016) Xiang Kong et al.   MEDICINE

Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064

(2016) Jamie E. Moscovitz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The pathophysiology of intrahepatic cholestasis of pregnancy

(2016) Peter H. Dixon et al.   Clinics and Research in Hepatology and Gastroenterology

Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels

(2015) Laura Brouwers et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy

(2015) Victoria Geenes et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

(2015) Shadi Abu-Hayyeh et al.   HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

(2014) Marcus G. Martineau et al.   DIABETES CARE

Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes

(2014) Marcus Martineau et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

The Reversed Feto-Maternal Bile Acid Gradient in Intrahepatic Cholestasis of Pregnancy Is Corrected by Ursodeoxycholic Acid

(2014) Victoria Geenes et al.   PLoS One

Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study

(2013) E Wikström Shemer et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study

(2013) Victoria Geenes et al.   HEPATOLOGY

Maternal cholestasis during pregnancy programs metabolic disease in offspring

(2013) Georgia Papacleovoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial

(2012) L. C. Chappell et al.   BMJ-British Medical Journal

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Microbial Community Development in a Dynamic Gut Model Is Reproducible, Colon Region Specific, and Selective for Bacteroidetes and Clostridium Cluster IX

(2010) P. Van den Abbeele et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function

(2010) Alexandra Milona et al.   HEPATOLOGY

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

(2009) Alexandra Milona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intrahepatic cholestasis of pregnancy

(2009) Victoria Geenes et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model

(2008) S. D. Baines et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY