Toll-like Receptors 7/8: A Paradigm for the Manipulation of Immunologic Reactions for Immunotherapy

Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases

(2022) Jun Liu et al.   Cell and Bioscience

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer

(2022) Jian Ye et al.   Journal for ImmunoTherapy of Cancer

Enhanced Delivery of TLR7/8 Agonists by Metal–Organic Frameworks for Hepatitis B Virus Cure

(2022) Liyuan Wang et al.   ACS Applied Materials & Interfaces

Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction

(2022) Luis Alejandro Zúñiga et al.   Cancer Cell International

Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives

(2022) Hao Sun et al.   Biomarker Research

The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent

(2021) Yinwen Cheng et al.   Scientific Reports

TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases

(2021) Marina Luchner et al.   Pharmaceutics

Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics

(2021) Xuan Huang et al.   Expert Opinion on Drug Discovery

Nile tilapia Toll-like receptor 7 subfamily: Intracellular TLRs that recruit MyD88 as an adaptor and activate the NF-κB pathway in the immune response

(2021) Fengying Gao et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans

(2021) Natarajan Ayithan et al.   Viruses-Basel

Aberrant anti-viral response of Natural Killer cell in severe asthma

(2020) Justine Devulder et al.   EUROPEAN RESPIRATORY JOURNAL

Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose

(2020) Shi-Wei Huang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice

(2020) Jiale Qu et al.   Journal of Immunology Research

IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells

(2020) Fridolin Franke et al.   Cells

Small-Molecule Modulators of Toll-like Receptors

(2020) Yibo Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Molecular and expression characterization of Toll-like receptor family genes from the Anadara sativa (Bivalvia, Arcidae) transcriptome

(2020) Yipeng Ren et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes

(2020) Cindy Patinote et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Toll-like receptors as a therapeutic target in cancer, infections and inflammatory diseases

(2020) Lizdany Flórez-Álvarez et al.   Immunotherapy

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci

(2020) Agata Famà et al.   mBio

Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

(2020) Shannon M. Miller et al.   Frontiers in Immunology

Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs

(2020) Franco Maximiliano Salinas et al.   ANTIVIRAL RESEARCH

Introduction to special issue: Pattern recognition receptors and their roles in immunity in invertebrates

(2020) Jin-Xing Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Retraction Note: Selected TLR7/8 agonist and type I interferon (IFN‑α) cooperatively redefine the microglia transcriptome

(2020) Mst Reshma Khatun et al.   INFLAMMOPHARMACOLOGY

Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22

(2020) Qinglan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

poly(D,L-lactide-co-glycolide) nanoparticles as a vaccine delivery platform for TLR7/8 agonist-based cancer vaccine

(2019) Hyunjoon Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mediators of Inflammation in Topical Therapy of Skin Cancers

(2019) Vlad Mihai Voiculescu et al.   MEDIATORS OF INFLAMMATION

Therapeutic potential of toll‐like receptors in treatment of gynecological cancers

(2019) Reyhaneh Moradi‐Marjaneh et al.   IUBMB LIFE

Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases

(2019) Mahesh Chandra Patra et al.   SEMINARS IN CANCER BIOLOGY

pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG

(2019) Jing Wu et al.   Journal of Immunology Research

Formulation and preclinical evaluation of a toll-like receptor 7/8 agonist as an anti-tumoral immunomodulator

(2019) Ruolin Lu et al.   JOURNAL OF CONTROLLED RELEASE

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

(2019) Massimo Vitale et al.   Frontiers in Immunology

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment

(2019) Nikaïa Smith et al.   Science Advances

Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

(2019) Stefanie R. Mullins et al.   Journal for ImmunoTherapy of Cancer

TLR8 Is a Sensor of RNase T2 Degradation Products

(2019) Wilhelm Greulich et al.   CELL

Endosomal toll‐like receptors play a key role in activation of primary human monocytes by cowpea mosaic virus

(2019) Marwah M. Albakri et al.   IMMUNOLOGY

Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis

(2019) Hideo Negishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists

(2019) Amanda B. Macedo et al.   Frontiers in Immunology

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

(2019) Zuzanna Urban-Wojciuk et al.   Frontiers in Immunology

TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages

(2019) Zhipeng Liu et al.   CANCER LETTERS

Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy

(2019) Qin Zeng et al.   CURRENT OPINION IN BIOTECHNOLOGY

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Differences in TLR7/8 activation between monocytes and macrophages

(2018) Hock-Liew Eng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

(2018) Karin Pelka et al.   IMMUNITY

Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation

(2018) Frances E Pearson et al.   IMMUNOLOGY AND CELL BIOLOGY

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

(2018) Casper Marsman et al.   IMMUNOLOGY AND CELL BIOLOGY

TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells

(2018) Mahyar Nouri-Shirazi et al.   IMMUNOLOGY LETTERS

TLR7-Mediated Lupus Nephritis Is Independent of Type I IFN Signaling

(2018) Sonya J. Wolf et al.   JOURNAL OF IMMUNOLOGY

2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus

(2018) Werner Embrechts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro

(2018) Ming-Xing Wang et al.   LIFE SCIENCES

Temporal cytokine and lymphoid responses to an inhaled TLR7 antedrug agonist in the cynomolgus monkey demonstrates potential safety and tolerability of this approach

(2018) John Bell et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin

(2018) Bénédicte Vanwalscappel et al.   VIROLOGY

Genital warts treatment: Beyond imiquimod

(2018) Jianwei Yuan et al.   Human Vaccines & Immunotherapeutics

Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells

(2018) Lorenza Tulli et al.   Frontiers in Immunology

Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck

(2018) Robert L. Ferris et al.   JAMA Oncology

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Innate immunity in the postmortem brain of depressed and suicide subjects: role of Toll-like receptors

(2018) Ghanshyam N. Pandey et al.   BRAIN BEHAVIOR AND IMMUNITY

Imiquimod enhances the potency of an exogenous BM-DC based vaccine against mouse melanoma

(2018) Shurong Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

(2018) Xiaohong Cen et al.   Frontiers in Pharmacology

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

(2018) Lutz Nuhn et al.   ADVANCED MATERIALS

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy

(2018) Arkadiusz Urbanowicz et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Recent clinical trends in Toll-like receptor targeting therapeutics

(2018) Muhammad Ayaz Anwar et al.   MEDICINAL RESEARCH REVIEWS

Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer

(2018) Lu Zhang et al.   NANO LETTERS

A small cysteine‐rich protein from two kingdoms of microbes is recognized as a novel pathogen‐associated molecular pattern

(2018) Jiajun Nie et al.   NEW PHYTOLOGIST

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

(2018) William McAlpine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation

(2018) Mélanie Souyris et al.   Seminars in Immunopathology

MDSC; the Most Important Cell You Have Never Heard Of

(2018) R.J. Tesi   TRENDS IN PHARMACOLOGICAL SCIENCES

Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy

(2018) Fumi Sato-Kaneko et al.   Biomed Research International

Critical role of Toll-like receptors in pathophysiology of allergic asthma

(2017) Seyyed Shamsadin Athari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword

(2017) Marion Dajon et al.   IMMUNOBIOLOGY

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

(2017) Christian Lood et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thermosensitive Gel–Based Formulation for Intratumoral Delivery of Toll-Like Receptor 7/8 Dual Agonist, MEDI9197

(2017) Amir Fakhari et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

(2017) Daniela Schmid et al.   Nature Communications

Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages

(2017) Alexandre Gidon et al.   PLoS Pathogens

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense

(2017) Philip O. Scumpia et al.   PLoS Pathogens

CD4 + T Cell and NK Cell Interplay Key to Regression of MHC Class I low Tumors upon TLR7/8 Agonist Therapy

(2017) Elien M. Doorduijn et al.   Cancer Immunology Research

A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines

(2017) Neal Van Hoeven et al.   Scientific Reports

6-(4-Amino-2-butyl-imidazoquinolyl)-norleucine: Toll-like receptor 7 and 8 agonist amino acid for self-adjuvanting peptide vaccine

(2016) Yoshio Fujita et al.   AMINO ACIDS

Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy

(2016) Bradley J. Monk et al.   CLINICAL CANCER RESEARCH

Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN

(2016) Laura Q.M. Chow et al.   CLINICAL CANCER RESEARCH

TLR7 Structure: Cut in Z-Loop

(2016) Kazuhiko Maeda et al.   IMMUNITY

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

(2016) Zhikuan Zhang et al.   IMMUNITY

How neutrophils kill fungi

(2016) Roel P. Gazendam et al.   IMMUNOLOGICAL REVIEWS

Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

(2016) Keith Biggadike et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

(2016) Sudhir Pai Kasturi et al.   JOURNAL OF VIROLOGY

Imidazoquinolines: Recent Developments in Anticancer Activity

(2016) Shivaputra A. Patil et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

(2016) Hiromi Tanji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR-activated plasmacytoid dendritic cells inhibit breast cancer cell growth in vitro and in vivo

(2016) Jing Wu et al.   Oncotarget

A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice

(2016) Gabriela Maria Wiedemann et al.   OncoImmunology

TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function

(2016) Thibaud Spinetti et al.   OncoImmunology

Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A

(2015) Y. Li et al.   BLOOD

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

(2015) Zhixia Zhou et al.   CANCER LETTERS

Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337)

(2015) G. N. Dietsch et al.   CLINICAL CANCER RESEARCH

TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer

(2015) TANJA GRIMMIG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells

(2015) Jing Wang et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors

(2015) Sebastian Schölch et al.   Oncotarget

TLR activation and ionizing radiation induce strong immune responses against multiple tumor entities

(2015) Sebastian Schölch et al.   OncoImmunology

Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells

(2014) Moonkyu Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non-Small Cell Lung Cancer

(2014) S. Chatterjee et al.   CANCER RESEARCH

A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma

(2014) D. W. Northfelt et al.   CLINICAL CANCER RESEARCH

Imiquimod Inhibits Melanoma Development by Promoting pDC Cytotoxic Functions and Impeding Tumor Vascularization

(2014) Caroline Aspord et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques

(2014) M. A. Moody et al.   JOURNAL OF VIROLOGY

Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

(2014) By Zhao et al.   Journal for ImmunoTherapy of Cancer

TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns

(2013) Elaine Cristina Cardoso et al.   PLoS One

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes

(2012) Hua Nian et al.   BMC INFECTIOUS DISEASES

Treatment of Autoimmune Inflammation by a TLR7 Ligand Regulating the Innate Immune System

(2012) Tomoko Hayashi et al.   PLoS One

Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation

(2012) Apostolis Stathopoulos et al.   OncoImmunology

The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)

(2011) M D Fidock et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss)

(2009) Yniv Palti et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY