Enhanced Delivery of TLR7/8 Agonists by Metal–Organic Frameworks for Hepatitis B Virus Cure

Mesoporous Silica Nanoparticles as pH-Responsive Carrier for the Immune-Activating Drug Resiquimod Enhance the Local Immune Response in Mice

(2021) Julia Wagner et al.   ACS Nano

Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics

(2021) Xuan Huang et al.   Expert Opinion on Drug Discovery

Multi-Immune Agonist Nanoparticle Therapy Stimulates Type I Interferons to Activate Antigen-Presenting Cells and Induce Antigen-Specific Antitumor Immunity

(2021) Elizabeth S. Levy et al.   MOLECULAR PHARMACEUTICS

Poly(ethylene glycol)-Mediated Assembly of Vaccine Particles to Improve Stability and Immunogenicity

(2021) Guiqiang Zhang et al.   ACS Applied Materials & Interfaces

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

(2021) Anne Huppertsberg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B

(2020) Wenjun Wang et al.   Nature Nanotechnology

Tetramodal Imaging and Synergistic Cancer Radio-Chemotherapy Enabled by Multiple Component-Encapsulated Zeolitic Imidazolate Frameworks

(2020) Yiwei Kang et al.   ACS Nano

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

(2020) Bi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity

(2020) Xia Li et al.   Nature Communications

Small molecule agonists of toll-like receptors 7 and 8: a patent review 2014 – 2020

(2020) Madeleine E. Kieffer et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Multiple Functions of B Cells in Chronic HBV Infection

(2020) Ying Cai et al.   Frontiers in Immunology

Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal–Organic Frameworks

(2019) Weibin Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy

(2019) Linhua Zhang et al.   NANO LETTERS

Combined GS-4774 and Tenofovir Therapy can Improve HBV-Specific T-Cell Responses in Patients with Chronic Hepatitis

(2019) Carolina Boni et al.   GASTROENTEROLOGY

Enhanced Stability and Controlled Delivery of MOF-Encapsulated Vaccines and Their Immunogenic Response In Vivo

(2019) Michael A. Luzuriaga et al.   ACS Applied Materials & Interfaces

Elimination Pathways of Nanoparticles

(2019) Wilson Poon et al.   ACS Nano

Characteristics of Impaired Dendritic Cell Function in Patients With Hepatitis B Virus Infection

(2019) Atsushi Yonejima et al.   HEPATOLOGY

An aluminum adjuvant-integrated nano-MOF as antigen delivery system to induce strong humoral and cellular immune responses

(2019) Xiaofang Zhong et al.   JOURNAL OF CONTROLLED RELEASE

Roadmap to Functional Cure of Chronic Hepatitis B: an expert consensus

(2019) Qin Ning et al.   JOURNAL OF VIRAL HEPATITIS

In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence

(2019) Quoc-Viet Le et al.   ACS Nano

Nanoparticle encapsulation of synergistic immune agonists enables systemic co-delivery to tumor sites and interferon β-driven anti-tumor immunity

(2019) Prabhani U. Atukorale et al.   CANCER RESEARCH

Hepatitis B Virus Reactivation: Risk Factors and Current Management Strategies

(2019) Danielle J. Smalls et al.   PHARMACOTHERAPY

Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications

(2018) Kuangda Lu et al.   ADVANCED MATERIALS

Circulating regulatory Tfh cells are enriched in patients with chronic hepatitis B infection and induce the differentiation of regulatory B cells

(2018) Rongxin Wang et al.   EXPERIMENTAL CELL RESEARCH

Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients

(2018) Xiaowen Wang et al.   GASTROENTEROLOGY

TLR7 Agonist Increases Responses of Hepatitis B Virus–Specific T Cells and Natural Killer Cells in Patients With Chronic Hepatitis B Treated With Nucleos(T)Ide Analogues

(2018) Carolina Boni et al.   GASTROENTEROLOGY

Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

(2018) Congrong Niu et al.   JOURNAL OF HEPATOLOGY

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination

(2018) Claudia Dembek et al.   Current Opinion in Virology

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

(2018) Lutz Nuhn et al.   ADVANCED MATERIALS

Antibodies@MOFs: An In Vitro Protective Coating for Preparation and Storage of Biopharmaceuticals

(2018) Yifan Feng et al.   ADVANCED MATERIALS

Effects of inorganic nanoparticles on liver fibrosis: Optimizing a double-edged sword for therapeutics

(2018) Jie Kai Tee et al.   BIOCHEMICAL PHARMACOLOGY

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

(2017) Pietro Lampertico et al.   JOURNAL OF HEPATOLOGY

Adaptive immunity in HBV infection

(2016) Antonio Bertoletti et al.   JOURNAL OF HEPATOLOGY

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance

(2015) B Ye et al.   Cell Death & Disease

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

(2014) Cheng Sun et al.   Cellular & Molecular Immunology

Targeting Innate Immunity: A New Step in the Development of Combination Therapy for Chronic Hepatitis B

(2013) Fabien Zoulim et al.   GASTROENTEROLOGY

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

(2013) Robert E. Lanford et al.   GASTROENTEROLOGY

Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+T-cell activation

(2013) Marzena Ciechomska et al.   IMMUNOLOGY

New perspectives in the therapy of chronic hepatitis B

(2012) Pietro Lampertico et al.   GUT

Comparison of human B cell activation by TLR7 and TLR9 agonists

(2008) John A Hanten et al.   BMC IMMUNOLOGY