Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine

(2018) Stephanie F. James et al.   ANNALS OF PHARMACOTHERAPY

Immunogenicity of a two-dose investigational hepatitis B vaccine, HBsAg-1018, using a toll-like receptor 9 agonist adjuvant compared with a licensed hepatitis B vaccine in adults

(2018) Sam Jackson et al.   VACCINE

Early bird gets the flu. What should be done about waning intraseasonal immunity against seasonal influenza?

(2018) Kunal J Rambhia et al.   CLINICAL INFECTIOUS DISEASES

Recombinant Zoster Vaccine (Shingrix®): A Review in Herpes Zoster

(2018) Yahiya Y. Syed   DRUGS & AGING

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

(2017) Sarang Tartey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Duration of Influenza Vaccine Effectiveness: A Systematic Review, Meta-analysis, and Meta-regression of Test-Negative Design Case-Control Studies

(2017) Barnaby Young et al.   JOURNAL OF INFECTIOUS DISEASES

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model

(2017) Alicja Misiak et al.   VACCINE

Tackling influenza with broadly neutralizing antibodies

(2017) Davide Corti et al.   Current Opinion in Virology

A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines

(2017) Neal Van Hoeven et al.   Scientific Reports

Heterogeneity of Human CD4+T Cells Against Microbes

(2016) Federica Sallusto   Annual Review of Immunology

Intraseason waning of influenza vaccine protection: Evidence from the US Influenza Vaccine Effectiveness Network, 2011-12 through 2014-15

(2016) Jill M. Ferdinands et al.   CLINICAL INFECTIOUS DISEASES

I-MOVE multicentre case–control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?

(2016) Esther Kissling et al.   Eurosurveillance

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

(2016) Christopher B. Fox et al.   JOURNAL OF CONTROLLED RELEASE

Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide

(2016) Alex Cortez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies

(2016) Edward A Belongia et al.   LANCET INFECTIOUS DISEASES

Phospholipidation of TLR7/8-active imidazoquinolines using a tandem phosphoramidite method

(2016) Hélène G. Bazin et al.   TETRAHEDRON LETTERS

Influenza vaccine effectiveness: Maintained protection throughout the duration of influenza seasons 2010–2011 through 2013–2014

(2016) Jennifer M. Radin et al.   VACCINE

Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants

(2016) Alyson J. Smith et al.   VACCINE

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

From discovery to licensure, the Adjuvant System story

(2016) Nathalie Garçon et al.   Human Vaccines & Immunotherapeutics

Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines

(2016) Cecilia Buonsanti et al.   Scientific Reports

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

(2015) Peter H. Goff et al.   JOURNAL OF VIROLOGY

Toll-like receptor signalling through macromolecular protein complexes

(2015) Clare E. Bryant et al.   MOLECULAR IMMUNOLOGY

Safety and effectiveness of MF-59 adjuvanted influenza vaccines in children and adults

(2015) Steven Black   VACCINE

H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps

(2015) Hang Xie et al.   Scientific Reports

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Intranasal Vaccination Promotes Detrimental Th17-Mediated Immunity against Influenza Infection

(2014) Asher Maroof et al.   PLoS Pathogens

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

(2013) Mark T. Orr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms

(2012) K. Kai McKinstry et al.   JOURNAL OF CLINICAL INVESTIGATION

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28

(2011) J. S. Pufnock et al.   BLOOD

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

(2011) C. Russo et al.   BLOOD

Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

(2011) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates

(2011) Jason T. Weinfurter et al.   PLoS Pathogens

HPV vaccine: Cervarix

(2010) Anne Szarewski   EXPERT OPINION ON BIOLOGICAL THERAPY

H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

(2010) Philippe Moris et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell-Mediated Protection against Lethal 2009 Pandemic H1N1 Influenza Virus Infection in a Mouse Model

(2010) H. Guo et al.   JOURNAL OF VIROLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus

(2009) K. A. Richards et al.   JOURNAL OF VIROLOGY

The ‘Ethereal’ nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics

(2008) Hélène G. Bazin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE