Review
Immunology
Bayley R. McRitchie, Billur Akkaya
Summary: The concept of cancer immunotherapy has made significant progress, but challenges related to the relationship between CD4(+) T cells and CD8(+) T cells and the immunosuppressive actions of Treg cells still require attention.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ariella Glasner, George Plitas
Summary: The immune system provides strong defense mechanisms against pathogens, but inadequate regulatory control can lead to various inflammatory disorders, including cancer. Treg cells play an important role in the tumor microenvironment, promoting tumor development by suppressing anti-tumor immune responses.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Oncology
Daniel R. Principe, Lauren Chiec, Nisha A. Mohindra, Hidayatullah G. Munshi
Summary: ICIs have revolutionized lung cancer treatment, but further research on immunosuppressive mechanisms in the lung cancer microenvironment is crucial for improving efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Guirong Liu, Manman Liu, Junjuan Wang, Yao Mou, Huilian Che
Summary: The increasing prevalence of food allergies has spurred research on novel treatment strategies like EPIT, which has shown potential in inducing immune tolerance. Treg cells play a key role in immune tolerance induced by EPIT but further exploration is needed to understand its mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ellen N. Scott, Angela M. Gocher, Creg J. Workman, Dario A. A. Vignali
Summary: Regulatory T cells utilize multiple suppressive mechanisms to hinder effector immune responses within the tumor microenvironment, creating a physical and biological barrier that results in immune exclusion or limitation within the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sarah I. M. Sutherland, Xinsheng Ju, L. G. Horvath, Georgina J. Clark
Summary: Despite the success of using checkpoint inhibitors to reprim T cells to recognize tumors in certain malignancies, including melanoma, lung, and renal cell carcinoma, many tumors, such as prostate cancer, remain resistant to such treatment. DC-based immunotherapy, such as Sipuleucel-T, has shown improved overall survival in prostate cancer, but further research into DC vaccines has been limited. Understanding the immunosuppressive environment of prostate cancer and developing new vaccine strategies that can overcome this environment is essential for future success in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Xueying Tang, Jiashuo Zhang, Dezhi Sui, Qiongfen Yang, Tianyu Wang, Zihan Xu, Xiaoya Li, Xin Gao, Xinyang Yan, Xinrong Liu, Yanzhi Song, Yihui Deng
Summary: This study developed a SA-modified mRNA vaccine that achieved successful DC targeting and efficient endosomal/lysosomal escape, resulting in higher transfection efficiency and lower side effects in DCs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Immunology
Ran Gao, Guo-Ping Shi, Jing Wang
Summary: Regulatory T cells (Tregs) are CD4(+) T cells that can suppress abnormal or excessive immune responses. Targeting Tregs selectively may alleviate their immunosuppressive activities and has shown promising results in preclinical and early-phase clinical trials. Combination therapy has been identified as a better choice than single immunotherapy, radiotherapy, or chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Yousif Saleh Ibrahim, Ali H. Amin, Zanko Hassan Jawhar, Mohammad A. Alghamdi, Ghaidaa Raheem Lateef Al-Awsi, Abdullah M. Shbeer, Hasan S. AL-Ghamdi, Gamal A. Gabr, Andres Alexis Ramirez-Coronel, Abbas F. Almulla
Summary: Despite progress in treating different malignancies, melanoma remains a lethal skin tumor type. Early diagnosis and surgery provide high survival rates, but advanced metastatic stages greatly decrease survival rates. Immunotherapeutics have shown promise in promoting tumor-specific immune responses, but adverse effects of Treg cells hinder clinical outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Wei Shi, Xiaomei Yang, Shenxia Xie, Dani Zhong, Xuandong Lin, Ziqiang Ding, Siliang Duan, Fengzhen Mo, Aiqun Liu, Shihua Yin, Xiaobing Jiang, Zhi Ping (Gordon) Xu, Xiaoling Lu
Summary: A strategy based on nanobody PD-1 Nb20 in combination with tumor-specific DC/FC vaccine enhanced the antitumor activity of CD8+ Tcells, demonstrating potential as an alternative immunotherapeutic strategy for tumor patients.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)