An updated view of the kinetochore architecture

Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres

(2023) Tatsuo Fukagawa et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2

(2023) Honghui Jiang et al.   EMBO JOURNAL

Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding

(2023) Soumitra Polley et al.   EMBO JOURNAL

Centromere/kinetochore is assembled through CENP-C oligomerization

(2023) Masatoshi Hara et al.   MOLECULAR CELL

Principles and dynamics of spindle assembly checkpoint signalling

(2023) Andrew D. McAinsh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conserved and divergent mechanisms of inner kinetochore assembly onto centromeric chromatin

(2023) Stanislau Yatskevich et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions

(2022) Yusuke Takenoshita et al.   Nature Communications

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

(2022) Marion E. Pesenti et al.   MOLECULAR CELL

CENP-N promotes the compaction of centromeric chromatin

(2022) Keda Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complete genomic and epigenetic maps of human centromeres

(2022) Nicolas Altemose et al.   SCIENCE

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

(2022) Stanislau Yatskevich et al.   SCIENCE

Repeat-based holocentromeres influence genome architecture and karyotype evolution

(2022) Paulo G. Hofstatter et al.   CELL

The Four Causes: The Functional Architecture of Centromeres and Kinetochores

(2022) Andrew D. McAinsh et al.   Annual Review of Genetics

Dynamic cell cycle–dependent phosphorylation modulates CENP-L–CENP-N centromere recruitment

(2022) Alexandra P. Navarro et al.   MOLECULAR BIOLOGY OF THE CELL

Structural insights into human CCAN complex assembled onto DNA

(2022) Tian Tian et al.   Cell Discovery

Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C

(2021) Mariko Ariyoshi et al.   EMBO JOURNAL

Assembly principles and stoichiometry of a complete human kinetochore module

(2021) Kai Walstein et al.   Science Advances

Diverse mechanisms of centromere specification

(2021) Barbara G. Mellone et al.   CURRENT BIOLOGY

The genetic and epigenetic landscape of the Arabidopsis centromeres

(2021) Matthew Naish et al.   SCIENCE

Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends

(2020) Ramachandran Boopathi et al.   NUCLEIC ACIDS RESEARCH

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

CDK phosphorylation of Xenopus laevis M18BP1 promotes its metaphase centromere localization

(2019) Bradley T French et al.   EMBO JOURNAL

The structure of the Ctf19c/CCAN from budding yeast

(2019) Stephen M Hinshaw et al.   eLife

Structure of the Human Core Centromeric Nucleosome Complex

(2019) Praveen Kumar Allu et al.   CURRENT BIOLOGY

Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment

(2019) Bing-Rui Zhou et al.   Nature Communications

CENP ‐C unwraps the human CENP ‐A nucleosome through the H2A C‐terminal tail

(2019) Ahmad Ali‐Ahmad et al.   EMBO REPORTS

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization

(2019) Reito Watanabe et al.   JOURNAL OF CELL BIOLOGY

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

(2019) Kaige Yan et al.   NATURE

Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore

(2018) Tian Tian et al.   CELL RESEARCH

Kinetochore assembly and disassembly during mitotic entry and exit

(2018) Masatoshi Hara et al.   CURRENT OPINION IN CELL BIOLOGY

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

(2018) Marion E. Pesenti et al.   MOLECULAR CELL

Multiple phosphorylations control recruitment of the KMN network onto kinetochores

(2018) Masatoshi Hara et al.   NATURE CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting of Arabidopsis KNL2 to Centromeres Depends on the Conserved CENPC-k Motif in Its C Terminus

(2017) Michael Sandmann et al.   PLANT CELL

Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N

(2017) Sagar Chittori et al.   SCIENCE

Decoding the centromeric nucleosome through CENP-N

(2017) Satyakrishna Pentakota et al.   eLife

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

(2017) Dongqing Pan et al.   eLife

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

(2016) Arsen Petrovic et al.   CELL

Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly

(2016) Yoana N. Dimitrova et al.   CELL

Kinetochore assembly and function through the cell cycle

(2016) Harsh Nagpal et al.   CHROMOSOMA

Progress in the structural and functional characterization of kinetochores

(2016) Marion E Pesenti et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Centromere localization and function of Mis18 requires Yippee‐like domain‐mediated oligomerization

(2016) Lakxmi Subramanian et al.   EMBO REPORTS

Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer

(2016) Isaac K. Nardi et al.   MOLECULAR CELL

Insights from biochemical reconstitution into the architecture of human kinetochores

(2016) John R. Weir et al.   NATURE

Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N

(2015) Junnan Fang et al.   GENES & DEVELOPMENT

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

Dynamic changes in CCAN organization through CENP-C during cell-cycle progression

(2015) Harsh Nagpal et al.   MOLECULAR BIOLOGY OF THE CELL

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface

(2015) Kara L. McKinley et al.   MOLECULAR CELL

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

The Kinetochore

(2014) I. M. Cheeseman   Cold Spring Harbor Perspectives in Biology

The quantitative architecture of centromeric chromatin

(2014) Dani L Bodor et al.   eLife

Functions of the centromere and kinetochore in chromosome segregation

(2013) Frederick G Westhorpe et al.   CURRENT OPINION IN CELL BIOLOGY

CENP-T provides a structural platform for outer kinetochore assembly

(2013) Tatsuya Nishino et al.   EMBO JOURNAL

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

(2013) H. Kato et al.   SCIENCE

CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

(2012) Tatsuya Nishino et al.   CELL

Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes

(2011) Ben E. Black et al.   CELL

Direct Binding of Cenp-C to the Mis12 Complex Joins the Inner and Outer Kinetochore

(2011) Emanuela Screpanti et al.   CURRENT BIOLOGY

Crystal structure of the human centromeric nucleosome containing CENP-A

(2011) Hiroaki Tachiwana et al.   NATURE

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

The CENP-S complex is essential for the stable assembly of outer kinetochore structure

(2009) Miho Amano et al.   JOURNAL OF CELL BIOLOGY

Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N

(2009) Christopher W. Carroll et al.   NATURE CELL BIOLOGY

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

(2008) Robin C. Allshire et al.   NATURE REVIEWS GENETICS

KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates

(2007) Iain M. Cheeseman et al.   MOLECULAR BIOLOGY OF THE CELL