Kinetochore assembly and function through the cell cycle

No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation

(2016) Silvana Rošić et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Attachment issues: kinetochore transformations and spindle checkpoint silencing

(2016) Banafsheh Etemad et al.   CURRENT OPINION IN CELL BIOLOGY

Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

(2016) Nuno M. C. Martins et al.   MOLECULAR BIOLOGY OF THE CELL

Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer

(2016) Isaac K. Nardi et al.   MOLECULAR CELL

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

(2016) Samantha J Falk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

(2016) Samantha J Falk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

(2016) Sushama Sivakumar et al.   eLife

Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T

(2015) Florencia Rago et al.   CURRENT BIOLOGY

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N

(2015) Junnan Fang et al.   GENES & DEVELOPMENT

Mammalian Polo-like Kinase 1 (Plk1) Promotes Proper Chromosome Segregation by Phosphorylating and Delocalizing the PBIP1·CENP-Q Complex from Kinetochores

(2015) Chi Hoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores

(2015) Soonjoung Kim et al.   JOURNAL OF CELL BIOLOGY

Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components

(2015) David J. Wynne et al.   JOURNAL OF CELL BIOLOGY

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly

(2015) N. Shono et al.   JOURNAL OF CELL SCIENCE

Identification of the Post-translational Modifications Present in Centromeric Chromatin

(2015) Aaron O. Bailey et al.   MOLECULAR & CELLULAR PROTEOMICS

Dynamic changes in CCAN organization through CENP-C during cell-cycle progression

(2015) Harsh Nagpal et al.   MOLECULAR BIOLOGY OF THE CELL

HJURP is involved in the expansion of centromeric chromatin

(2015) Marinela Perpelescu et al.   MOLECULAR BIOLOGY OF THE CELL

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface

(2015) Kara L. McKinley et al.   MOLECULAR CELL

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

(2015) Mathijs Vleugel et al.   MOLECULAR CELL

Adaptive changes in the kinetochore architecture facilitate proper spindle assembly

(2015) Valentin Magidson et al.   NATURE CELL BIOLOGY

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex

(2015) Emily M. Kudalkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint

(2015) Gang Zhang et al.   Nature Communications

A quantitative description of Ndc80 complex linkage to human kinetochores

(2015) Aussie Suzuki et al.   Nature Communications

HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment

(2015) Hiroaki Tachiwana et al.   Cell Reports

The distinct functions of CENP-C and CENP-T/W in centromere propagation and function inXenopusegg extracts

(2015) Iva Krizaic et al.   Nucleus

The distinct functions of CENP-C and CENP-T/W in centromere propagation and function inXenopusegg extracts

(2015) Iva Krizaic et al.   Nucleus

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres

(2014) Kara L. McKinley et al.   CELL

The CENP-O complex requirement varies among different cell types

(2014) Naoko Kagawa et al.   CHROMOSOME RESEARCH

Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

(2014) Tetsuya Hori et al.   DEVELOPMENTAL CELL

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

(2014) Gary M.R. Deyter et al.   GENES & DEVELOPMENT

Mitotic Regulator Mis18β Interacts with and Specifies the Centromeric Assembly of Molecular Chaperone Holliday Junction Recognition Protein (HJURP)

(2014) Jianyu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct kinetochore–spindle pole connections are not required for chromosome segregation

(2014) Vitali Sikirzhytski et al.   JOURNAL OF CELL BIOLOGY

The dynamic protein Knl1 - a kinetochore rendezvous

(2014) P. Ghongane et al.   JOURNAL OF CELL SCIENCE

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

(2014) J. Bancroft et al.   JOURNAL OF CELL SCIENCE

The spindle and kinetochore–associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit

(2014) Sushama Sivakumar et al.   MOLECULAR BIOLOGY OF THE CELL

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin

(2014) Teppei Kitagawa et al.   Nature Communications

Structural basis for microtubule recognition by the human kinetochore Ska complex

(2014) Maria Alba Abad et al.   Nature Communications

A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle

(2014) C. Dornblut et al.   Open Biology

Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects

(2014) Ines A Drinnenberg et al.   eLife

The quantitative architecture of centromeric chromatin

(2014) Dani L Bodor et al.   eLife

Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

(2014) Jan Wisniewski et al.   eLife

Cell division: control of the chromosomal passenger complex in time and space

(2013) Armando van der Horst et al.   CHROMOSOMA

Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres

(2013) Wei-Hao Shang et al.   DEVELOPMENTAL CELL

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

(2013) Francesca Malvezzi et al.   EMBO JOURNAL

CENP-T provides a structural platform for outer kinetochore assembly

(2013) Tatsuya Nishino et al.   EMBO JOURNAL

The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly

(2013) Tetsuya Hori et al.   JOURNAL OF CELL BIOLOGY

Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores

(2013) Dileep Varma et al.   JOURNAL OF CELL BIOLOGY

The KMN protein network - chief conductors of the kinetochore orchestra

(2013) D. Varma et al.   JOURNAL OF CELL SCIENCE

The centromeric nucleosome-like CENP–T–W–S–X complex induces positive supercoils into DNA

(2013) Kozo Takeuchi et al.   NUCLEIC ACIDS RESEARCH

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

(2013) H. Kato et al.   SCIENCE

An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation

(2013) Stephen M. Hinshaw et al.   Cell Reports

CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

(2012) Tatsuya Nishino et al.   CELL

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly

(2012) Emily A. Bassett et al.   DEVELOPMENTAL CELL

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments

(2012) Jens C. Schmidt et al.   DEVELOPMENTAL CELL

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

(2012) Jun-ichirou Ohzeki et al.   EMBO JOURNAL

Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction

(2012) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore

(2012) Julien Espeut et al.   JOURNAL OF CELL BIOLOGY

Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

(2012) J. H. Bergmann et al.   JOURNAL OF CELL SCIENCE

The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores

(2012) Gang Zhang et al.   JOURNAL OF CELL SCIENCE

Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading

(2012) Ik Soo Kim et al.   MOLECULAR CELL

Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface

(2012) A. Arockia Jeyaprakash et al.   MOLECULAR CELL

Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore

(2012) Lucy J. Bock et al.   NATURE CELL BIOLOGY

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Sub-Complex

(2012) Anja Eskat et al.   PLoS One

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm

(2012) Nitika Raychaudhuri et al.   PLOS BIOLOGY

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin

(2012) Silvia Dambacher et al.   Nucleus

Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes

(2011) Karen E. Gascoigne et al.   CELL

The Spatial Arrangement of Chromosomes during Prometaphase Facilitates Spindle Assembly

(2011) Valentin Magidson et al.   CELL

The ABCs of CENPs

(2011) Marinela Perpelescu et al.   CHROMOSOMA

Direct Binding of Cenp-C to the Mis12 Complex Joins the Inner and Outer Kinetochore

(2011) Emanuela Screpanti et al.   CURRENT BIOLOGY

KNL1/Spc105 Recruits PP1 to Silence the Spindle Assembly Checkpoint

(2011) Jessica S. Rosenberg et al.   CURRENT BIOLOGY

CENP-C Is a Structural Platform for Kinetochore Assembly

(2011) Marcin R. Przewloka et al.   CURRENT BIOLOGY

Spindle Checkpoint Silencing Requires Association of PP1 to Both Spc7 and Kinesin-8 Motors

(2011) John C. Meadows et al.   DEVELOPMENTAL CELL

Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

(2011) Mariana C.C. Silva et al.   DEVELOPMENTAL CELL

Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP

(2011) H. Hu et al.   GENES & DEVELOPMENT

Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-CENP-Q Complex at Kinetochores

(2011) Young H. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins

(2011) Aussie Suzuki et al.   JOURNAL OF CELL BIOLOGY

CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly

(2011) Ben Moree et al.   JOURNAL OF CELL BIOLOGY

HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

(2011) Meghan C. Barnhart et al.   JOURNAL OF CELL BIOLOGY

Dynamics of CENP-N kinetochore binding during the cell cycle

(2011) D. Hellwig et al.   JOURNAL OF CELL SCIENCE

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State

(2011) Lisa Prendergast et al.   PLOS BIOLOGY

Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis

(2011) Barbara G. Mellone et al.   PLoS Genetics

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

(2010) Yumi Kim et al.   CELL

Drosophila CENP-C is essential for centromere identity

(2010) Bernardo Orr et al.   CHROMOSOMA

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment

(2010) Shasha Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complex

(2010) Fabienne Lampert et al.   JOURNAL OF CELL BIOLOGY

The MIS12 complex is a protein interaction hub for outer kinetochore assembly

(2010) Arsen Petrovic et al.   JOURNAL OF CELL BIOLOGY

Dual recognition of CENP-A nucleosomes is required for centromere assembly

(2010) Christopher W. Carroll et al.   JOURNAL OF CELL BIOLOGY

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Tension directly stabilizes reconstituted kinetochore-microtubule attachments

(2010) Bungo Akiyoshi et al.   NATURE

Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation

(2010) Tatsuya Tsukahara et al.   NATURE

Molecular control of kinetochore-microtubule dynamics and chromosome oscillations

(2010) Ana C. Amaro et al.   NATURE CELL BIOLOGY

HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

(2010) M. Shuaib et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis

(2009) John R. Daum et al.   CURRENT BIOLOGY

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility

(2009) Julie P.I. Welburn et al.   DEVELOPMENTAL CELL

Stable kinetochore–microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3

(2009) Thomas N Gaitanos et al.   EMBO JOURNAL

Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division

(2009) Mirko Theis et al.   EMBO JOURNAL

Kinetochore stretching inactivates the spindle assembly checkpoint

(2009) Kazuhiko S.K. Uchida et al.   JOURNAL OF CELL BIOLOGY

Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

(2009) Thomas J. Maresca et al.   JOURNAL OF CELL BIOLOGY

The CENP-S complex is essential for the stable assembly of outer kinetochore structure

(2009) Miho Amano et al.   JOURNAL OF CELL BIOLOGY

Hierarchical Inactivation of a Synthetic Human Kinetochore by a Chromatin Modifier

(2009) Stefano Cardinale et al.   MOLECULAR BIOLOGY OF THE CELL

Dissection of CENP-C–directed Centromere and Kinetochore Assembly

(2009) Kirstin J. Milks et al.   MOLECULAR BIOLOGY OF THE CELL

Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N

(2009) Christopher W. Carroll et al.   NATURE CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

(2008) Owen J. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

Phosphorylation of HsMis13 by Aurora B Kinase Is Essential for Assembly of Functional Kinetochore

(2008) Yong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of inner kinetochore assembly and maintenance in living cells

(2008) Peter Hemmerich et al.   JOURNAL OF CELL BIOLOGY

Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

(2008) Robin C. Allshire et al.   NATURE REVIEWS GENETICS

KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates

(2007) Iain M. Cheeseman et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY