Assessing micro- and nanoplastics toxicity using rodent models: investigating potential mitochondrial implications

The emerging role of microplastics in systemic toxicity: Involvement of reactive oxygen species (ROS)

(2023) Amlan Das   Science of The Total Environment

Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring

(2022) Tao Huang et al.   FOOD AND CHEMICAL TOXICOLOGY

Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway

(2022) Haibo Jin et al.   Particle and Fibre Toxicology

The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases

(2022) Liliana M. Almeida et al.   BIOLOGICAL REVIEWS

Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice

(2022) Xuran Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Discovery and quantification of plastic particle pollution in human blood

(2022) Heather A. Leslie et al.   ENVIRONMENT INTERNATIONAL

Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines

(2022) Jiaru Jing et al.   ENVIRONMENT INTERNATIONAL

Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement

(2022) Yanting Li et al.   ENVIRONMENT INTERNATIONAL

Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway

(2022) Rong Shen et al.   ENVIRONMENTAL POLLUTION

Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine

(2022) Shuwei Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice

(2022) Chiang-Wen Lee et al.   JOURNAL OF HAZARDOUS MATERIALS

Consequences of nano and microplastic exposure in rodent models: the known and unknown

(2022) Walison Augusto da Silva Brito et al.   Particle and Fibre Toxicology

A new discovery of polystyrene microplastics toxicity: The injury difference on bladder epithelium of mice is correlated with the size of exposed particles

(2022) Yue Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice

(2022) Zahra Aghaei et al.   Environmental Science & Technology Letters

Identification of ceRNA network to explain the mechanism of cognitive dysfunctions induced by PS NPs in mice

(2022) Chen Chu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis

(2022) Diqi Yang et al.   ENVIRONMENT INTERNATIONAL

Orally administered fluorescent nanosized polystyrene particles affect cell viability, hormonal and inflammatory profile, and behavior in treated mice

(2022) Sandra Nikolic et al.   ENVIRONMENTAL POLLUTION

Mitochondria research and neurodegenerative diseases: On the track to understanding the biological world of high complexity

(2022) Daniela Mendes et al.   MITOCHONDRION

Detection of microplastics in human lung tissue using μFTIR spectroscopy

(2022) Lauren C. Jenner et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Eco-corona formation and associated ecotoxicological impacts of nanoplastics in the environment

(2022) Shulin Liu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk

(2022) Antonio Ragusa et al.   Polymers

Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics

(2022) Jun Shi et al.   CHEMOSPHERE

Microplastics induce immune suppression via S100A8 downregulation

(2022) Juan WANG et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice

(2022) Madjid Djouina et al.   ENVIRONMENTAL RESEARCH

Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice

(2022) Hao Wu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data

(2022) Xuebing Chen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Impact of Micro- and Nanoplastics on Mitochondria

(2022) Seung Eun Lee et al.   Metabolites

Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio)

(2022) Luís Félix et al.   CHEMOSPHERE

Microplastics from headwaters to tap water: occurrence and removal in a drinking water treatment plant in Barcelona Metropolitan area (Catalonia, NE Spain)

(2021) Joan Dalmau-Soler et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Zebrafish as an animal model for biomedical research

(2021) Tae-Young Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

EVIDENCE from in VITRO and IN VIVO studies on the potential health REPERCUSSIONS of MICRO- and nanoplastics

(2021) Anabel González-Acedo et al.   CHEMOSPHERE

Size-dependent chronic toxicity of fragmented polyethylene microplastics to Daphnia magna

(2021) Dahee An et al.   CHEMOSPHERE

Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats

(2021) Junyu Hou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Microplastics impair olfactory-mediated behaviors of goldfish Carassius auratus

(2021) Wei Shi et al.   JOURNAL OF HAZARDOUS MATERIALS

Questioning the Suitability of Available Microplastics Models for Risk Assessment – A Critical Review

(2021) Andrey Ethan Rubin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish

(2021) Sathisaran Umamaheswari et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interactions between microplastics and soil fauna: A critical review

(2021) Quanlong Wang et al.   CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY

Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice

(2021) Hanqing Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice

(2021) Rongli Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Results of a 30-day safety assessment in young mice orally exposed to polystyrene nanoparticles

(2021) Junting Xiao et al.   ENVIRONMENTAL POLLUTION

Deep Dive into Plastic Monomers, Additives, and Processing Aids

(2021) Helene Wiesinger et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Microplastics in fresh and processed mussels sampled from fish shops and large retail chains in Italy

(2021) L. Nalbone et al.   FOOD CONTROL

Microplastic pollution in aquatic environments with special emphasis on riverine systems: Current understanding and way forward

(2021) Mansi Vaid et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload

(2021) Siwen Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Microplastics in seawater and two sides of the Taiwan Strait: Reflection of the social-economic development

(2021) Qianqian Wu et al.   MARINE POLLUTION BULLETIN

A One Health perspective of the impacts of microplastics on animal, human and environmental health

(2021) Joana C. Prata et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway

(2021) Lingai Pan et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Natural and anthropogenic effects on microplastic distribution in a hypersaline lagoon

(2021) Mariana Quesadas-Rojas et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microplastics in soil: A review on methods, occurrence, sources, and potential risk

(2021) Ling Yang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A comparative review of microplastics in lake systems from different countries and regions

(2021) Siyuan Yang et al.   CHEMOSPHERE

Genotoxic effect of microplastics and COVID-19: The hidden threat

(2021) Ghada Tagorti et al.   CHEMOSPHERE

Effects of nano- and microplastics on kidney: Physicochemical properties, bioaccumulation, oxidative stress and immunoreaction

(2021) Xuemei Meng et al.   CHEMOSPHERE

Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice

(2021) Xingpei Fan et al.   CHEMOSPHERE

Vertical microplastic distribution in sediments of Fuhe River estuary to Baiyangdian Wetland in Northern China

(2021) Zeyan Zhou et al.   CHEMOSPHERE

Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells

(2021) Liangtao Zhao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Updated review on microplastics in water, their occurrence, detection, measurement, environmental pollution, and the need for regulatory standards

(2021) Ahmed Yusuf et al.   ENVIRONMENTAL POLLUTION

Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2

(2021) Yuexin Wei et al.   ENVIRONMENTAL POLLUTION

Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system

(2021) Zachary Lett et al.   ENVIRONMENTAL POLLUTION

Legislation to limit the environmental plastic and microplastic pollution and their influence on human exposure

(2021) Ilaria Conti et al.   ENVIRONMENTAL POLLUTION

Effects of ingestion of polyethylene microplastics on survival rate, opercular respiration rate and swimming performance of African catfish (Clarias gariepinus)

(2021) Isioma Tongo et al.   JOURNAL OF HAZARDOUS MATERIALS

Seeking for a perfect (non-spherical) microplastic particle – The most comprehensive review on microplastic laboratory research

(2021) Ula Rozman et al.   JOURNAL OF HAZARDOUS MATERIALS

Polystyrene microplastics induced female reproductive toxicity in mice

(2021) Zhiqiang Liu et al.   JOURNAL OF HAZARDOUS MATERIALS

Investigation of microplastics in edible wild mussels from İzmir Bay (Aegean Sea, Western Turkey): A risk assessment for the consumers

(2021) Aykut Yozukmaz   MARINE POLLUTION BULLETIN

Polystyrene microplastic particles induce endothelial activation

(2021) Ann-Kathrin Vlacil et al.   PLoS One

Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice

(2021) Jianing Hu et al.   REPRODUCTIVE TOXICOLOGY

Occurrence, distribution and affecting factors of microplastics in agricultural soils along the lower reaches of Yangtze River, China

(2021) Lu Cao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo

(2021) Wookbong Kwon et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice

(2021) Zhaolan Wei et al.   TOXICOLOGY

Detection and characterization of small-sized microplastics (≥ 5 µm) in milk products

(2021) Paulo A. Da Costa Filho et al.   Scientific Reports

Occurrence, human exposure, and risk of microplastics in the indoor environment

(2021) Hassan Khalid Ageel et al.   Environmental Science-Processes & Impacts

Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

(2021) Yingwen Mu et al.   CHEMOSPHERE

Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny

(2021) Bohyeon Jeong et al.   JOURNAL OF HAZARDOUS MATERIALS

Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var. larvae

(2020) Xiaohua Xia et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation

(2020) Eun-Jung Park et al.   TOXICOLOGY LETTERS

The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge

(2020) Fatemeh Amereh et al.   ENVIRONMENTAL POLLUTION

An emerging class of air pollutants: Potential effects of microplastics to respiratory human health?

(2020) Luís Fernando Amato-Lourenço et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways

(2020) Moyan Hu et al.   Redox Biology

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

(2020) Kaili Ma et al.   Frontiers in Cell and Developmental Biology

Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats

(2020) Zekang Li et al.   ENVIRONMENTAL POLLUTION

Microplastics and associated contaminants in the aquatic environment: A review on their ecotoxicological effects, trophic transfer, and potential impacts to human health

(2020) Wei Huang et al.   JOURNAL OF HAZARDOUS MATERIALS

Estimation of the mass of microplastics ingested – A pivotal first step towards human health risk assessment

(2020) Kala Senathirajah et al.   JOURNAL OF HAZARDOUS MATERIALS

Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice

(2020) Baolian Hou et al.   JOURNAL OF HAZARDOUS MATERIALS

Microplastics in Mediterranean coastal area: toxicity and impact for the environment and human health

(2020) Marta Llorca et al.   Trends in Environmental Analytical Chemistry

Plasticenta: First evidence of microplastics in human placenta

(2020) Antonio Ragusa et al.   ENVIRONMENT INTERNATIONAL

Plastic density as a key factor in the presence of microplastic in the gastrointestinal tract of commercial fishes from Campeche Bay, Mexico

(2020) Merle M. Borges-Ramírez et al.   ENVIRONMENTAL POLLUTION

Polystyrene microplastics induced male reproductive toxicity in mice

(2020) Haibo Jin et al.   JOURNAL OF HAZARDOUS MATERIALS

First detection of microplastics in the freshwater of an Antarctic Specially Protected Area

(2020) Miguel González-Pleiter et al.   MARINE POLLUTION BULLETIN

Environmental fate, ecotoxicity biomarkers, and potential health effects of micro- and nano-scale plastic contamination

(2020) Prabhat Kumar Rai et al.   JOURNAL OF HAZARDOUS MATERIALS

Uptake, tissue distribution and toxicological effects of environmental microplastics in early juvenile fish Dicentrarchus labrax

(2020) Nesrine Zitouni et al.   JOURNAL OF HAZARDOUS MATERIALS

Potential human health risks due to environmental exposure to nano- and microplastics and knowledge gaps: A scoping review

(2020) Arifur Rahman et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats

(2020) Ru An et al.   TOXICOLOGY

Toxic effects of naturally-aged microplastics on zebrafish juveniles: A more realistic approach to plastic pollution in freshwater ecosystems

(2020) Abraão Tiago Batista Guimarães et al.   JOURNAL OF HAZARDOUS MATERIALS

Human Consumption of Microplastics

(2019) Kieran D. Cox et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Interaction between microplastics and microorganism as well as gut microbiota: A consideration on environmental animal and human health

(2019) Liang Lu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Simulating human exposure to indoor airborne microplastics using a Breathing Thermal Manikin

(2019) Alvise Vianello et al.   Scientific Reports

Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics

(2019) Ponnusamy Manogaran Gopinath et al.   Scientific Reports

Detection of Various Microplastics in Human Stool

(2019) Philipp Schwabl et al.   ANNALS OF INTERNAL MEDICINE

ROS generation and DNA damage contribute to abamectin-induced cytotoxicity in mouse macrophage cells

(2019) Yiran Liang et al.   CHEMOSPHERE

Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway

(2019) Xiaoman Xie et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Butylated hydroxytoluene induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in mouse Leydig cell death

(2019) Jiyeon Ham et al.   ENVIRONMENTAL POLLUTION

Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring

(2019) Ting Luo et al.   ENVIRONMENTAL POLLUTION

Environmental exposure to microplastics: An overview on possible human health effects

(2019) Joana Correia Prata et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice

(2019) Boqing Li et al.   CHEMOSPHERE

The role of mitochondria in cellular toxicity as a potential drug target

(2018) Duojiao Wu et al.   CELL BIOLOGY AND TOXICOLOGY

Airborne microplastics: Consequences to human health?

(2018) Joana Correia Prata   ENVIRONMENTAL POLLUTION

Current opinion: What is a nanoplastic?

(2018) Julien Gigault et al.   ENVIRONMENTAL POLLUTION

Contamination of table salts from Turkey with microplastics

(2018) Sedat Gündoğdu   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

An overview of chemical additives present in plastics: Migration, release, fate and environmental impact during their use, disposal and recycling

(2018) John N. Hahladakis et al.   JOURNAL OF HAZARDOUS MATERIALS

Toxicological effects of irregularly shaped and spherical microplastics in a marine teleost, the sheepshead minnow ( Cyprinodon variegatus )

(2018) Jin Soo Choi et al.   MARINE POLLUTION BULLETIN

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

(2018) Liang Lu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Mitochondrial Toxicity

(2018) Joel N Meyer et al.   TOXICOLOGICAL SCIENCES

Synthetic Polymer Contamination in Bottled Water

(2018) Sherri A. Mason et al.   Frontiers in Chemistry

Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice

(2018) Yuanxiang Jin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microplastics as contaminants in commercially important seafood species

(2017) David Santillo et al.   Integrated Environmental Assessment and Management

Production, use, and fate of all plastics ever made

(2017) Roland Geyer et al.   Science Advances

Is there any consistency between the microplastics found in the field and those used in laboratory experiments?

(2016) Nam Ngoc Phuong et al.   ENVIRONMENTAL POLLUTION

In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction

(2016) Arcangelo Barbonetti et al.   REPRODUCTIVE TOXICOLOGY

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

Microplastics in bivalves cultured for human consumption

(2014) Lisbeth Van Cauwenberghe et al.   ENVIRONMENTAL POLLUTION

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

Chronic ketamine administration impairs mitochondrial complex I in the rat liver

(2013) Carlos Venâncio et al.   LIFE SCIENCES

Acute Brain Damage Induced by Acetaminophen in Mice: Effect of Diphenyl Diselenide on Oxidative Stress and Mitochondrial Dysfunction

(2011) Michele Hinerasky da Silva et al.   NEUROTOXICITY RESEARCH

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL