Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway

Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage

(2021) Nengzhou Chen et al.   ENVIRONMENTAL POLLUTION

Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae

(2020) Hui Yang et al.   JOURNAL OF HAZARDOUS MATERIALS

Microplastics in waters and soils: Occurrence, analytical methods and ecotoxicological effects

(2020) Mengjie Wu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

As3+ or/and Cu2+ exposure triggers oxidative stress imbalance, induces inflammatory response and apoptosis in chicken brain

(2020) Xiaopan Nie et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Endoplasmic reticulum stress and protein degradation in chronic liver disease

(2020) Si-Wei Xia et al.   PHARMACOLOGICAL RESEARCH

Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway

(2020) Siwen Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Zinc offers splenic protection through suppressing PERK/IRE1-driven apoptosis pathway in common carp (Cyprinus carpio) under arsenic stress

(2020) Yu Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects

(2020) Siwen Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts

(2020) Hua-Long Zhu et al.   ENVIRONMENT INTERNATIONAL

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling

(2019) Wei Zheng et al.   Cell Communication and Signaling

Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation

(2019) Bo Ma et al.   PHYTOMEDICINE

Exploring the kidney hazard of exposure to mercuric chloride in mice:Disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis

(2019) Siyu Li et al.   CHEMOSPHERE

Taxifolin alleviates apoptotic injury induced by DEHP exposure through cytochrome P450 homeostasis in chicken cardiomyocytes

(2019) Yuan Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Taxifolin ameliorates DEHP-induced cardiomyocyte hypertrophy via attenuating mitochondrial dysfunction and glycometabolism disorder in chicken

(2019) Jingzeng Cai et al.   ENVIRONMENTAL POLLUTION

Hepatotoxicity of pristine polyethylene microplastics in neotropical physalaemus cuvieri tadpoles (Fitzinger, 1826)

(2019) Amanda Pereira da Costa Araújo et al.   JOURNAL OF HAZARDOUS MATERIALS

Role of p62 in the regulation of cell death induction

(2018) Lihong Fan et al.   APOPTOSIS

Accumulation of polystyrene microplastics in juvenile Eriocheir sinensis and oxidative stress effects in the liver

(2018) Ping Yu et al.   AQUATIC TOXICOLOGY

Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation

(2018) Liang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice

(2018) Runping Liu et al.   HEPATOLOGY

Marine microplastic debris: An emerging issue for food security, food safety and human health

(2018) Luís Gabriel Antão Barboza et al.   MARINE POLLUTION BULLETIN

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

(2018) Liang Lu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microplastics in freshwater systems: A review on occurrence, environmental effects, and methods for microplastics detection

(2018) Jingyi Li et al.   WATER RESEARCH

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Polystyrene microplastics alter the behavior, energy reserve and nutritional composition of marine jacopever (Sebastes schlegelii)

(2018) Liyun Yin et al.   JOURNAL OF HAZARDOUS MATERIALS

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Activation of PERK-eIF2α-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity

(2018) Min-Ge Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

(2018) Zhe Zhang et al.   Redox Biology

Microplastic abundance, distribution and composition in the Pearl River along Guangzhou city and Pearl River estuary, China

(2018) Muting Yan et al.   CHEMOSPHERE

Biocorona formation contributes to silver nanoparticle induced endoplasmic reticulum stress

(2018) Indushekhar Persaud et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Plastic and Human Health: A Micro Issue?

(2017) Stephanie L. Wright et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Endoplasmic reticulum stress-mediated autophagy activation attenuates fumonisin B1 induced hepatotoxicity in vitro and in vivo

(2017) Mahendra Pal Singh et al.   FOOD AND CHEMICAL TOXICOLOGY

Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

(2017) Yongfeng Deng et al.   Scientific Reports

Plastic Debris Is a Human Health Issue

(2016) A. Dick Vethaak et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils

(2016) Claudie Noël et al.   TOXICOLOGY IN VITRO

A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis

(2015) Motoko Sasaki et al.   JOURNAL OF GASTROENTEROLOGY

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics

(2014) Randal J. Kaufman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single and combined effects of microplastics and pyrene on juveniles (0+ group) of the common goby Pomatoschistus microps (Teleostei, Gobiidae)

(2013) M. Oliveira et al.   ECOLOGICAL INDICATORS

Policy: Classify plastic waste as hazardous

(2013) Chelsea M. Rochman et al.   NATURE

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum

(2007) Lai Wei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY