Mitochondria research and neurodegenerative diseases: On the track to understanding the biological world of high complexity

Cardiolipin, Mitochondria, and Neurological Disease

(2021) Micol Falabella et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial Dynamics: A Key Role in Neurodegeneration and a Potential Target for Neurodegenerative Disease

(2021) Danying Yang et al.   Frontiers in Neuroscience

Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases

(2021) Keelan Jagaran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration

(2021) Shirel Argueti-Ostrovsky et al.   Cells

A nanophytosomes formulation based on elderberry anthocyanins and Codium lipids to mitigate mitochondrial dysfunctions

(2021) Daniela Mendes et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery

(2021) Anna Picca et al.   Biomolecules

Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

(2020) Xusan Yang et al.   Nature Communications

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

(2020) Gabriella Marucci et al.   NEUROPHARMACOLOGY

Structure of the dimeric ATP synthase from bovine mitochondria

(2020) Tobias E. Spikes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice

(2020) Maria A. Tikhonova et al.   MOLECULES

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network

(2019) Amy E. Vincent et al.   Cell Reports

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

A new insight on elderberry anthocyanins bioactivity: Modulation of mitochondrial redox chain functionality and cell redox state

(2019) Dina Neves et al.   Journal of Functional Foods

A photostable fluorescent marker for the superresolution live imaging of the dynamic structure of the mitochondrial cristae

(2019) Chenguang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin

(2019) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Parkinson disease

(2019) R. Balestrino et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

(2019) Yuanbo Wu et al.   MITOCHONDRION

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease

(2019) Carroll Rutherford Fields et al.   Frontiers in Molecular Neuroscience

USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis

(2018) Emanuele Barca et al.   HUMAN MOLECULAR GENETICS

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

­­Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force­

(2018) Claudio Anselmi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology

(2018) Daniela Mendes et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mitochondria are physiologically maintained at close to 50 °C

(2018) Dominique Chrétien et al.   PLOS BIOLOGY

ATP Synthase Diseases of Mitochondrial Genetic Origin

(2018) Alain Dautant et al.   Frontiers in Physiology

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease

(2018) Magali Dumont et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of Alpha-Lipoic Acid on Memory, Oxidation, and Lifespan in SAMP8 Mice

(2018) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

(2018) Lynne Shinto et al.   JOURNAL OF ALZHEIMERS DISEASE

Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Vera F. Monteiro-Cardoso et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial dynamics, a key executioner in neurodegenerative diseases

(2018) Komal Panchal et al.   MITOCHONDRION

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease

(2017) P. Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Inhibition of mitochondrial fragmentation protects against Alzheimer’s disease in rodent model

(2017) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

(2017) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

(2017) José Teixeira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Muscle Non-shivering Thermogenesis and Its Role in the Evolution of Endothermy

(2017) Julia Nowack et al.   Frontiers in Physiology

Levodopa in Parkinson’s Disease: Current Status and Future Developments

(2017) Nicola Tambasco et al.   Current Neuropharmacology

An antioxidant specifically targeting mitochondria delays progression of Alzheimer’s disease-like pathology

(2016) Natalia Stefanova et al.   Aging-US

Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis

(2016) A. Solmonson et al.   ENDOCRINOLOGY

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

(2016) Susana Cardoso et al.   Expert Review of Neurotherapeutics

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

(2016) Anamitra Ghosh et al.   Journal of Neuroimmune Pharmacology

Genetic and biochemical intricacy shapes mitochondrial cytopathies

(2016) Douglass M. Turnbull et al.   NEUROBIOLOGY OF DISEASE

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

(2016) Susana Cardoso et al.   Expert Review of Neurotherapeutics

LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease

(2015) Y. Y. Tyurina et al.   FREE RADICAL RESEARCH

Dietary Tocotrienol/γ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice

(2015) Anke Schloesser et al.   Oxidative Medicine and Cellular Longevity

Decoding bioactive polar lipid profile of the macroalgae Codium tomentosum from a sustainable IMTA system using a lipidomic approach

(2015) Elisabete da Costa et al.   Algal Research-Biomass Biofuels and Bioproducts

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

(2014) et al.   JAMA Neurology

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

(2013) Huajun Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The systems biology of mitochondrial fission and fusion and implications for disease and aging

(2013) Anuradha Chauhan et al.   BIOGERONTOLOGY

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Cytometric assessment of mitochondria using fluorescent probes

(2011) Cécile Cottet-Rousselle et al.   CYTOMETRY PART A

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

(2011) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and l-dopa toxicity

(2011) Amany A. Abdin et al.   NEUROSCIENCE RESEARCH

Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies

(2010) Ahmed A Heikal   Biomarkers in Medicine

Mitochondrial Dynamics in Alzheimerʼs Disease

(2010) David J. Bonda et al.   DRUGS & AGING

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

(2010) Anamitra Ghosh et al.   FREE RADICAL BIOLOGY AND MEDICINE

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

The architecture of respiratory complex I

(2010) Rouslan G. Efremov et al.   NATURE

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

(2009) Lichuan Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Row-like organization of ATP synthase in intact mitochondria determined by cryo-electron tomography

(2009) Natalya V. Dudkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria: A therapeutic target in neurodegeneration

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protein Misfolding and Neurodegeneration

(2008) Claudio Soto et al.   ARCHIVES OF NEUROLOGY

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial ATP synthase disorders: Molecular mechanisms and the quest for curative therapeutic approaches

(2008) Roza Kucharczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial dysfunction in rat brain with agingInvolvement of complex I, reactive oxygen species and cardiolipin

(2008) G PETROSILLO et al.   NEUROCHEMISTRY INTERNATIONAL

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL