Mitochondrial Toxicity

Innate immunity and tolerance toward mitochondria

(2018) Anthony Rongvaux   MITOCHONDRION

Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice

(2017) Aaron M. Gusdon et al.   EXPERIMENTAL GERONTOLOGY

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial

(2017) Jia Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

(2017) A. Phillip West   TOXICOLOGY

Mitochondrial-epigenetic crosstalk in environmental toxicology

(2017) Caren Weinhouse   TOXICOLOGY

Mitochondrial fusion, fission, and mitochondrial toxicity

(2017) Joel N. Meyer et al.   TOXICOLOGY

The use of high-throughput screening techniques to evaluate mitochondrial toxicity

(2017) Lauren P. Wills   TOXICOLOGY

Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity

(2017) Joel N. Meyer et al.   TOXICOLOGY

Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability

(2017) Anthony L. Luz et al.   TOXICOLOGY

Mitochondria targeting by environmental stressors: Implications for redox cellular signaling

(2017) Chuck Blajszczak et al.   TOXICOLOGY

Inherited mitochondrial genomic instability and chemical exposures

(2017) Sherine S.L. Chan   TOXICOLOGY

Ecological significance of mitochondrial toxicants

(2017) Nishad Jayasundara   TOXICOLOGY

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

(2017) André Ferreira et al.   TOXICOLOGY

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts

(2017) Vera Adam-Vizi et al.   JOURNAL OF ALZHEIMERS DISEASE

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture

(2016) Alexandra I. Mot et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

(2016) Eligio F Iannetti et al.   Nature Protocols

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial DNA exhibits resistance to induced point and deletion mutations

(2016) William J. Valente et al.   NUCLEIC ACIDS RESEARCH

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

A combined in vitro approach to improve the prediction of mitochondrial toxicants

(2016) Julie Eakins et al.   TOXICOLOGY IN VITRO

Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations

(2016) Jessica L. Saben et al.   Cell Reports

The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective

(2016) Madhusudana Rao Chikka et al.   Cell Reports

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Multiple Targets for Drug-Induced Mitochondrial Toxicity

(2015) Kendall Wallace   CURRENT MEDICINAL CHEMISTRY

The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos

(2015) Jennifer E. Bestman et al.   DIFFERENTIATION

Integrating mitochondriomics in children's environmental health

(2015) Kelly J. Brunst et al.   JOURNAL OF APPLIED TOXICOLOGY

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay

(2015) Lauren P. Wills et al.   TOXICOLOGICAL SCIENCES

High-Throughput Tissue Bioenergetics Analysis Reveals Identical Metabolic Allometric Scaling for Teleost Hearts and Whole Organisms

(2015) Nishad Jayasundara et al.   PLoS One

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans

(2014) Claudia P. González-Hunt et al.   PLoS One

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

(2014) Pénélope A. Andreux et al.   Scientific Reports

Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity

(2014) William Dott et al.   Redox Biology

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

(2013) Sebastian Schmeisser et al.   AGING CELL

How mitochondrial dysfunction affects zebrafish development and cardiovascular function: anin vivomodel for testing mitochondria-targeted drugs

(2013) Brígida R Pinho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systematic Study of Mitochondrial Toxicity of Environmental Chemicals Using Quantitative High Throughput Screening

(2013) Matias S. Attene-Ramos et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effects of airborne pollutants on mitochondrial DNA Methylation

(2013) Hyang-Min Byun et al.   Particle and Fibre Toxicology

Mitochondria as a Target of Environmental Toxicants

(2013) Joel N. Meyer et al.   TOXICOLOGICAL SCIENCES

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death

(2013) Rachel Swiss et al.   TOXICOLOGY IN VITRO

Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

(2012) Amanda S. Bess et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

(2012) Claudia V. Pereira et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis

(2011) Jonathan P. Little et al.   Applied Physiology Nutrition and Metabolism

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Discovering environmental causes of disease

(2011) Stephen M Rappaport   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference

(2011) Hans-Olov Adami et al.   TOXICOLOGICAL SCIENCES

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

(2010) Craig C. Beeson et al.   ANALYTICAL BIOCHEMISTRY

Pharmacologic effects on mitochondrial function

(2010) Bruce H. Cohen   Developmental Disabilities Research Reviews

Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity

(2010) Steven Zuryn et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Meeting report: Identification of biomarkers for early detection of mitochondrial dysfunction

(2010) Daniel T. Shaughnessy et al.   MITOCHONDRION

Progressive Mitochondrial Compromise in Brains and Livers of Primates Exposed In Utero to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

(2010) Rao L. Divi et al.   TOXICOLOGICAL SCIENCES

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy

(2010) Rui A. Carvalho et al.   TOXICOLOGY

Oral–aboral axis specification in the sea urchin embryo

(2009) James A. Coffman et al.   DEVELOPMENTAL BIOLOGY

Reactive oxygen species are signalling molecules for skeletal muscle adaptation

(2009) Scott K. Powers et al.   EXPERIMENTAL PHYSIOLOGY

The heterozygous Sod2+/− mouse: modeling the mitochondrial role in drug toxicity

(2008) Urs A. Boelsterli et al.   DRUG DISCOVERY TODAY

Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition

(2008) Magnus J. Hansson et al.   FREE RADICAL BIOLOGY AND MEDICINE