A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
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Title
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
Authors
Keywords
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Journal
TOXICOLOGICAL SCIENCES
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2023-09-29
DOI
10.1093/toxsci/kfad101
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Note: Only part of the references are listed.- Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
- (2023) Serat-E Ali et al. Chemical Research in Toxicology
- HLA Class-II‒Restricted CD8+ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients
- (2021) Qing Zhao et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
- (2021) Monday O Ogese et al. TOXICOLOGICAL SCIENCES
- Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury
- (2021) Christopher A. Schofield et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Cross-reactivity between vancomycin, teicoplanin and telavancin in HLA-A*32:01 positive vancomycin DRESS patients sharing an HLA-Class II haplotype
- (2020) Nontaya Nakkam et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds
- (2020) Monday O Ogese et al. TOXICOLOGICAL SCIENCES
- Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity
- (2020) Ramona Nudischer et al. PLoS One
- HLA‐B*35:01 and Green Tea Induced Liver Injury
- (2020) Jay H. Hoofnagle et al. HEPATOLOGY
- Characterisation of healthy donor-derived T-cell responses specific to telaprevir diastereomers
- (2019) Khetam Ali Alhilali et al. TOXICOLOGICAL SCIENCES
- HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms
- (2019) Katherine C. Konvinse et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Exosomal transport of hepatocyte‐derived drug‐modified proteins to the immune system
- (2019) Monday O. Ogese et al. HEPATOLOGY
- Mechanistic Studies of Idiosyncratic DILI: Clinical Implications
- (2019) Jack Uetrecht Frontiers in Pharmacology
- HLA-DRB1*07:01 and lapatinib-induced hepatotoxicity: a systematic review and meta-analysis
- (2019) Wimonchat Tangamornsuksan et al. PHARMACOGENOMICS JOURNAL
- Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity
- (2018) Toru Usui et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
- (2018) J. Gerry Kenna et al. DRUG METABOLISM AND DISPOSITION
- HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors
- (2018) Toru Usui et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Drug-induced liver injury: recent advances in diagnosis and risk assessment
- (2017) Gerd A Kullak-Ublick et al. GUT
- Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells
- (2017) Andrew Gibson et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗ 35:02 as a risk factor
- (2017) Thomas Jacob Urban et al. JOURNAL OF HEPATOLOGY
- The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors
- (2017) Andrew Gibson et al. JOURNAL OF IMMUNOLOGY
- Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back–Looking Forward to Next-Generation Innovation
- (2017) Zelalem Petros et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity
- (2016) Lee Faulkner et al. TOXICOLOGICAL SCIENCES
- In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski’s Base
- (2015) Andrew Gibson et al. CHEMICAL RESEARCH IN TOXICOLOGY
- HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity
- (2015) Elena M. Cornejo Castro et al. Pharmacogenetics and Genomics
- ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
- (2014) Naga P Chalasani et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function
- (2014) A. Gibson et al. JOURNAL OF IMMUNOLOGY
- Identification and frequency of circulating CD4+T lymphocytes specific to Benzylpenicillin in healthy donors
- (2013) C. Nhim et al. ALLERGY
- Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds
- (2012) Melanie Z. Sakatis et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury
- (2012) Manal M. Monshi et al. HEPATOLOGY
- The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs
- (2012) Lee Faulkner et al. TOXICOLOGICAL SCIENCES
- Human T cell priming assay (hTCPA) for the identification of contact allergens based on naive T cells and DC – IFN-γ and TNF-α readout
- (2012) Anne Richter et al. TOXICOLOGY IN VITRO
- Clinical and Histopathologic Features of Fluoroquinolone-Induced Liver Injury
- (2011) Eric S. Orman et al. Clinical Gastroenterology and Hepatology
- FDA-approved drug labeling for the study of drug-induced liver injury
- (2011) Minjun Chen et al. DRUG DISCOVERY TODAY
- Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome
- (2011) Tai-Ming Ko et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Hepatic safety of antibiotics used in primary care
- (2011) R. J. Andrade et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan
- (2011) Pei Chen et al. NEW ENGLAND JOURNAL OF MEDICINE
- HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans
- (2011) Mark McCormack et al. NEW ENGLAND JOURNAL OF MEDICINE
- T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays
- (2010) Stefan F. Martin et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Stimulation of human T cells with sulfonamides and sulfonamide metabolites
- (2010) J. Luis Castrejon et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Tracking Human Contact Allergens: From Mass Spectrometric Identification of Peptide-Bound Reactive Small Chemicals to Chemical-Specific Naive Human T-Cell Priming
- (2010) Lisa Dietz et al. TOXICOLOGICAL SCIENCES
- Characterization of p-Phenylenediamine–Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein
- (2009) Claire Jenkinson et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals
- (2009) Eve M. Coulter et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
- (2009) Ann K Daly et al. NATURE GENETICS
- Depletion of Human Peripheral Blood Lymphocytes in CD25+ Cells Allows for the Sensitive In Vitro Screening of Contact Allergens
- (2008) Marc Vocanson et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Activation of T-Cells from Allergic Patients and Volunteers by p-Phenylenediamine and Bandrowski's Base
- (2007) Eve Marie Coulter et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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