Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds

Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo

(2019) Arun Tailor et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity

(2018) Toru Usui et al.   CHEMICAL RESEARCH IN TOXICOLOGY

β-Lactam hypersensitivity involves expansion of circulating and skin-resident T H 22 cells

(2018) Andrew Sullivan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions

(2018) Chuang-Wei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells

(2017) Andrew Gibson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients

(2017) Xiaoli Meng et al.   JOURNAL OF IMMUNOLOGY

The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

(2017) Andrew Gibson et al.   JOURNAL OF IMMUNOLOGY

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

(2016) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma

(2015) N. Yamazaki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski’s Base

(2015) Andrew Gibson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms

(2014) H. Morito et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

(2014) A. Gibson et al.   JOURNAL OF IMMUNOLOGY

Electrochemistry/liquid chromatography/mass spectrometry to demonstrate irreversible binding of the skin allergen p-phenylenediamine to proteins

(2012) Sandra Jahn et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

(2012) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

(2011) P. Whitaker et al.   JOURNAL OF IMMUNOLOGY

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

(2010) Stefan F. Martin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stimulation of human T cells with sulfonamides and sulfonamide metabolites

(2010) J. Luis Castrejon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tracking Human Contact Allergens: From Mass Spectrometric Identification of Peptide-Bound Reactive Small Chemicals to Chemical-Specific Naive Human T-Cell Priming

(2010) Lisa Dietz et al.   TOXICOLOGICAL SCIENCES

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

(2009) Hayley E. Callan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human naive and memory CD4+T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells

(2009) Rebekka Geiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective Regulatory T Cells In Patients with Severe Drug Eruptions: Timing of the Dysfunction Is Associated with the Pathological Phenotype and Outcome

(2009) R. Takahashi et al.   JOURNAL OF IMMUNOLOGY

Characterization of p-Phenylenediamine–Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein

(2009) Claire Jenkinson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Depletion of Human Peripheral Blood Lymphocytes in CD25+ Cells Allows for the Sensitive In Vitro Screening of Contact Allergens

(2008) Marc Vocanson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of T-Cells from Allergic Patients and Volunteers by p-Phenylenediamine and Bandrowski's Base

(2007) Eve Marie Coulter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY