Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System

HLA Class-II‒Restricted CD8+ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients

(2021) Qing Zhao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds

(2020) Monday O Ogese et al.   TOXICOLOGICAL SCIENCES

Identification of flucloxacillin-haptenated HLA-B*57:01 ligands: evidence of antigen processing and presentation

(2020) J C Waddington et al.   TOXICOLOGICAL SCIENCES

HLA DRB1*15:01-DQB1*06:02-restricted human CD4+ T-cells are selectively activated with amoxicillin-peptide adducts

(2020) Arun Tailor et al.   TOXICOLOGICAL SCIENCES

Identification and characterization of a naïve CD8+ T-cell repertoire for benzylpenicillin

(2019) Rami Bechara et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dapsone- and nitroso dapsone-specific activation of T-cells from hypersensitive patients expressing the risk allele HLA-B*13:01

(2019) Qing Zhao et al.   ALLERGY

Sulfonamide Hypersensitivity: Fact and Fiction

(2019) David A. Khan et al.   Journal of Allergy and Clinical Immunology-In Practice

Sulfonamide Drug Allergy

(2018) Joshua M. Dorn et al.   CURRENT ALLERGY AND ASTHMA REPORTS

The Function of HLA-B*13:01 Involved in the Pathomechanism of Dapsone-Induced Severe Cutaneous Adverse Reactions

(2018) Wei-Ti Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13

(2017) Therdpong Tempark et al.   Pharmacogenetics and Genomics

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis

(2015) M. O. Ogese et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Oxypurinol Directly and Immediately Activates the Drug-Specific T Cells via the Preferential Use of HLA-B*58:01

(2014) J. Yun et al.   JOURNAL OF IMMUNOLOGY

HLA-B*13:01 and the Dapsone Hypersensitivity Syndrome

(2013) F.-R. Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

(2012) Patricia T. Illing et al.   NATURE

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

(2012) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

Stimulation of human T cells with sulfonamides and sulfonamide metabolites

(2010) J. Luis Castrejon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY