Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

(2018) Lorna Ewart et al.   Annual Review of Pharmacology and Toxicology

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

(2018) Lucija Kuna et al.   CURRENT DRUG METABOLISM

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

(2018) Shishir Shetty et al.   Nature Reviews Gastroenterology & Hepatology

Liposomal formulation of a methotrexate lipophilic prodrug: assessment in tumor cells and mouse T-cell leukemic lymphoma

(2017) Anna Alekseeva et al.   International Journal of Nanomedicine

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acetaminophen toxicity in rat and mouse hepatocytes in vitro

(2016) Otto Kučera et al.   DRUG AND CHEMICAL TOXICOLOGY

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity

(2016) Kelly A. Rose et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction

(2016) Masataka Santoh et al.   Scientific Reports

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model

(2015) Leonard J. Nelson et al.   Scientific Reports

Competency of different cell models to predict human hepatotoxic drugs

(2014) M José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Drug-Induced Hepatic Steatosis

(2014) Naga Chalasani et al.   SEMINARS IN LIVER DISEASE

Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity

(2013) L. Schyschka et al.   ARCHIVES OF TOXICOLOGY

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Effect of Lipopolysaccharide on the Xenobiotic-Induced Expression and Activity of Hepatic Cytochrome P450 in Mice

(2012) Nozomu Moriya et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Coordinating genome expression with cell size

(2012) Samuel Marguerat et al.   TRENDS IN GENETICS

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters

(2010) J. S. Lagas et al.   MOLECULAR PHARMACOLOGY

Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

(2009) Yusuke Sakai et al.   CELLS TISSUES ORGANS

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

In Vitro Studies are Sometimes Better than Conventional Human Pharmacokinetic In Vivo Studies in Assessing Bioequivalence of Immediate-Release Solid Oral Dosage Forms

(2008) James E. Polli   AAPS Journal

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

(2008) Colleen M. Brophy et al.   HEPATOLOGY

Acute Liver Failure Including Acetaminophen Overdose

(2008) Robert J. Fontana   MEDICAL CLINICS OF NORTH AMERICA

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES