Recent advances in atroposelective synthesis of axially chiral heterobiaryl featuring indole frameworks

Silver-Catalyzed Direct Nucleophilic Cyclization: Enantioselective De Novo Synthesis of C–C Axially Chiral 2-Arylindoles

(2023) Liangbin Yu et al.   Organic Letters

Stereogenic-at-Cobalt(III) Complex Catalyzed Halocyclization of Alkynes: Enantioselective Access to Axially Chiral ortho-Halo-C2-indoles

(2023) Chuan-Zhi Yao et al.   Journal of Organic Chemistry

Chiral Acid-Catalyzed Atroposelective Indolization Enables Access to 1,1′-Indole-Pyrroles and Bisindoles Bearing a Chiral N–N Axis

(2023) Luo-Yu Wang et al.   Organic Letters

Atroposelective Synthesis of Axially Chiral Styrenes Connecting an Axially Chiral Naphthyl-indole Moiety Using Chiral Phosphoric Acid Catalysis

(2023) Alemayehu Gashaw Woldegiorgis et al.   Organic Letters

Recent Advances in Indole Synthesis and the Related Alkylation

(2023) Jie Ma et al.   Asian Journal of Organic Chemistry

Dynamic Kinetic Resolution of Indole-Based Sulfenylated Heterobiaryls by Rhodium-Catalyzed Atroposelective Reductive Aldol Reaction

(2023) Carlos Rodríguez-Franco et al.   ACS Catalysis

Cobalt-Catalyzed Enantioselective C–H Arylation of Indoles

(2022) Nicolas Jacob et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-Metal-Catalyzed Enantioselective Synthesis of Indoles from 2-Alkynylanilines

(2022) Zhi-Shi Ye et al.   SYNTHESIS-STUTTGART

Organocatalytic cycloaddition of alkynylindoles with azonaphthalenes for atroposelective construction of indole-based biaryls

(2022) Hui Yang et al.   Nature Communications

Catalytic asymmetric synthesis of 3,4′-indole–pyrazole derivatives featuring axially chiral bis-pentatomic heteroaryls

(2022) Chenghao Li et al.   Organic Chemistry Frontiers

Catalytic Asymmetric Synthesis of Axially Chiral 3,3'‐Bisindoles by Direct Coupling of Indole Rings

(2022) Feng‐Tao Sheng et al.   CHINESE JOURNAL OF CHEMISTRY

Rhodium-Catalyzed Atroposelective C–H Arylation of (Hetero)Arenes Using Carbene Precursors as Arylating Reagents

(2022) Yun Zou et al.   ORGANIC LETTERS

Rhodium(III)-Catalyzed Atroposelective Synthesis of C–N Axially Chiral Naphthylamines and Variants via C–H Activation

(2022) Peiyuan Wang et al.   ORGANIC LETTERS

Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis

(2022) Guang-Jian Mei et al.   Chem

Atroposelective Synthesis of Axially Chiral C2-Arylindoles via Rhodium-Catalyzed Asymmetric C–H Bond Insertion

(2022) Junheng Liu et al.   ORGANIC LETTERS

Construction of Axially Chiral Indoles by Cycloaddition–Isomerization via Atroposelective Phosphoric Acid and Silver Sequential Catalysis

(2022) Yingcheng Wang et al.   ACS Catalysis

Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications

(2022) Hong-Hao Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Atropisomerism in the Pharmaceutically Relevant Realm

(2022) Mariami Basilaia et al.   ACCOUNTS OF CHEMICAL RESEARCH

Atroposelective Synthesis of N-Arylindoles via Enantioselective N–H Bond Insertion

(2022) Chao Niu et al.   ORGANIC LETTERS

Design and catalytic atroposelective synthesis of axially chiral isochromenone-indoles

(2022) Qing-Qing Hang et al.   Science China-Chemistry

Facile Assembly of Modular-Type Phosphines for Tackling Modern Arylation Processes

(2022) Man Ho Tse et al.   Accounts of Chemical Research

Design and Organocatalytic Asymmetric Synthesis of Indolyl-Pyrroloindoles Bearing Both Axial and Central Chirality

(2022) Hai-Qing Wang et al.   Journal of Organic Chemistry

Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds

(2022) Xiaoke Zhang et al.   MOLECULES

Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution

(2022) Patricia Rodríguez-Salamanca et al.   ACS Catalysis

Pd-Catalyzed Enantioselective Tandem C–C Bond Activation/Cacchi Reaction between Cyclobutanones and o-Ethynylanilines

(2021) Wan-Chun Yang et al.   ORGANIC LETTERS

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Atroposelective Construction of Axially Chiral Alkene‐Indole Scaffolds via Catalytic Enantioselective Addition Reaction of 3‐Alkynyl ‐2‐indolylmethanols

(2021) Jing‐Yi Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Recent Advances in Catalytic Atroposelective Construction of Pentatomic Heterobiaryl Scaffolds

(2021) Xiao‐Long He et al.   ChemCatChem

Asymmetric Synthesis of Axially Chiral Naphthyl-C3-indoles via a Palladium-Catalyzed Cacchi Reaction

(2021) Cong-Shuai Wang et al.   ORGANIC LETTERS

Rational design and atroposelective synthesis of N–N axially chiral compounds

(2021) Guang-Jian Mei et al.   Chem

Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N -Aryl Indoles via Vinylidene Ortho -Quinone Methides

(2021) Da Xu et al.   CCS Chemistry

Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles

(2021) Saad Shaaban et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Enantioselective C–H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents

(2021) Hao Liang et al.   ORGANIC LETTERS

Asymmetric synthesis of N–N axially chiral compounds via organocatalytic atroposelective N-acylation

(2021) Wei Lin et al.   Chemical Science

Chiral-Phosphoric-Acid-Catalyzed Atroposelective C-H Amination of Arenes

(2020) Bin Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atroposelective Synthesis of 3,3’‐Bisindoles Bearing Axial and Central Chirality: Using Isatin‐Derived Imines as Electrophiles

(2020) Feng‐Tao Sheng et al.   CHINESE JOURNAL OF CHEMISTRY

Advances in the Catalytic Asymmetric Synthesis of Atropisomeric Hexatomic N‐Heterobiaryls

(2020) Dao-Juan Cheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Construction of Axially Chiral Indole‐Based Frameworks: An Emerging Area

(2020) Tian-Zhen Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Axially Chiral Aryl‐Alkene‐Indole Framework: A Nascent Member of the Atropisomeric Family and Its Catalytic Asymmetric Construction

(2020) Cong‐Shuai Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Catalytic Asymmetric Synthesis of 3,3′-Bisindoles Bearing Single Axial Chirality

(2020) Ke-Wei Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Atroposelective Synthesis of Axially Chiral 3-Arylindoles by Copper-Catalyzed Asymmetric Cross-Coupling of Indoles with Quinones and Naphthoquinones

(2020) Chao-Chao Xi et al.   ORGANIC LETTERS

Chiral Naphthyl-C2-Indole as Scaffold for Phosphine Organocatalysis: Application in Asymmetric Formal [4 + 2] Cycloaddition Reactions

(2020) Tingting He et al.   ORGANIC LETTERS

Rhodium‐Catalyzed Atroposelective Construction of Indoles via C‐H Bond Activation

(2020) Lincong Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atropselective Dibrominations of a 1,1’-Disubstituted 2,2’-Biindolyl With Diverging Point-to-Axial Asymmetric Inductions. Deriving Diphosphane Ligands for Asymmetric Catalysis

(2019) Reinhard Brückner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

(2019) Yongseok Kwon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Biaryl Atropisomers via Pd-Catalyzed C-H Olefination using Chiral Spiro Phosphoric Acid Ligands

(2019) Jun Luo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction into Enantioenriched 3-Arylpyrroles

(2019) Sheng-Cai Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

(2019) Miaomiao Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of N–C Axial Chirality through Atroposelective C–H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis

(2019) Jitan Zhang et al.   ORGANIC LETTERS

An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis

(2019) Jin-Yu Liu et al.   ORGANIC LETTERS

Atroposelective Construction of Arylindoles by Chiral Phosphoric Acid-Catalyzed Cross-Coupling of Indoles and Quinones

(2019) Dong-Liang Lu et al.   ORGANIC LETTERS

Central‐to‐Axial Chirality Conversion Approach Designed on Organocatalytic Enantioselective Povarov Cycloadditions: First Access to Configurationally Stable Indole‐Quinoline Atropisomers

(2019) Vasco Corti et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles

(2019) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Annulation of ortho -Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-indoles

(2019) Lei Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Strategy for Synthesizing Axially Chiral Naphthyl-Indoles: Catalytic Asymmetric Addition Reactions of Racemic Substrates

(2019) Fei Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereo- and Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade

(2019) Shenci Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles

(2019) Yu-Ping He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in the Catalytic Functionalization of “Electrophilic” Indoles

(2019) Alessandro Cerveri et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis and antimicrobial activity of β-carboline derivatives with N 2 -alkyl modifications

(2018) Kenji Suzuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Bird's Eye View of Atropisomers Featuring a Five-Membered Ring

(2018) Damien Bonne et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Atropisomerism in medicinal chemistry: challenges and opportunities

(2018) Sean T Toenjes et al.   Future Medicinal Chemistry

Access to P - and Axially Chiral Biaryl Phosphine Oxides by Enantioselective Cpx IrIII -Catalyzed C−H Arylations

(2018) Yun-Suk Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cp*Co(iii)-Catalyzed oxidative [5+2] annulation: regioselective synthesis of 2-aminobenzoxepines via C–H/O–H functionalization of 2-vinylphenols with ynamides

(2018) Xiang-Lei Han et al.   CHEMICAL COMMUNICATIONS

Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes

(2018) Sachie Arae et al.   ORGANIC LETTERS

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles

(2018) Sheng-Cai Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Catalytic Asymmetric Construction of Axially Chiral 3,3′-Bisindole Skeletons

(2018) Chun Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

(2018) Adriana E. Tron et al.   Nature Communications

Substrate-Controlled Regioselective Arylations of 2-Indolylmethanols with Indoles: Synthesis of Bis(indolyl)methane and 3,3′-Bisindole Derivatives

(2017) Ying-Ying He et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

(2017) Vivek S. Raut et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic asymmetric arylation of indoles enabled by azo groups

(2017) Liang-Wen Qi et al.   Nature Chemistry

Quinine-Catalyzed Asymmetric Synthesis of 2,2′-Binaphthol-Type Biaryls under Mild Reaction Conditions

(2016) Mauro Moliterno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Enantioselective Construction of Axially Chiral Naphthyl-Indole Skeletons

(2016) Hong-Hao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives

(2016) Jin-Zheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective synthesis of N-arylindoles and related compounds with axially chiral N–C bonds

(2016) Shunsuke Kinoshita et al.   TETRAHEDRON

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.

(2015) John G. Luz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2-Naphthols

(2015) Ye-Hui Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A twist of nature – the significance of atropisomers in biological systems

(2015) Jamie E. Smyth et al.   NATURAL PRODUCT REPORTS

Rhodium(III)-Catalyzed Cyclative Capture Approach to Diverse 1-Aminoindoline Derivatives at Room Temperature

(2014) Dongbing Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic enantioselective and (Z)-selective allylation of 3-indolylmethanol via hydrogen-bond activation

(2014) Yan Liu et al.   CHEMICAL COMMUNICATIONS

Asymmetric Synthesis of α-Branched Amines via Rh(III)-Catalyzed C–H Bond Functionalization

(2014) Apiwat Wangweerawong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 2-Aryl-2H-benzotrizoles from Azobenzenes and N-Sulfonyl Azides through Sequential Rhodium-Catalyzed Amidation and Oxidation in One Pot

(2014) Taekyu Ryu et al.   ORGANIC LETTERS

First Total Synthesis of Murrastifoline B and an Improved Route to Murrastifoline F

(2014) Hans-Joachim Knölker et al.   SYNLETT

Chemicals from Alkynes with Palladium Catalysts

(2013) Rafael Chinchilla et al.   CHEMICAL REVIEWS

Direct Access to Acylated Azobenzenes via Pd-Catalyzed C–H Functionalization and Further Transformation into an Indazole Backbone

(2013) Hongji Li et al.   ORGANIC LETTERS

Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion

(2012) Bo Yao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

(2012) Zhongli Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Coupling ofortho-Alkynylanilines with Terminal Alkynes Under Aerobic Conditions: Efficient Synthesis of 2,3-Disubstituted 3-Alkynylindoles

(2012) Bo Yao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete

(2012) Qingbo Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Synthesis of Atropisomeric Indoles with an NC Chiral Axis

(2010) Nobutaka Ototake et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Aryl indole-derived C–N bond axially chiral phosphine ligands: synthesis and application in palladium-catalyzed asymmetric allylic alkylation

(2010) Takashi Mino et al.   TETRAHEDRON-ASYMMETRY

Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

(2009) Alessandro Palmieri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY