Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds

Cu(II)-Catalyzed Construction of Heterobiaryls using 1-Diazonaphthoquinones: A General Strategy for the Synthesis of QUINOX and Related P,N Ligands

(2022) Aniruddha Biswas et al.   ORGANIC LETTERS

Brønsted acid-enhanced copper-catalyzed atroposelective cycloisomerization to axially chiral arylquinolizones via dearomatization of pyridine

(2022) Xiao-Long Min et al.   Nature Communications

Organocatalytic cycloaddition of alkynylindoles with azonaphthalenes for atroposelective construction of indole-based biaryls

(2022) Hui Yang et al.   Nature Communications

Enantioselective Rh-Catalyzed Azide-Internal-Alkyne Cycloaddition for the Construction of Axially Chiral 1,2,3-Triazoles

(2022) Wen-Ting Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Azide–Alkyne Cycloaddition with Ir(I)/Squaramide Cooperative Catalysis: Atroposelective Synthesis of Axially Chiral Aryltriazoles

(2022) Xue Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(III)-Catalyzed Atroposelective Synthesis of C–N Axially Chiral Naphthylamines and Variants via C–H Activation

(2022) Peiyuan Wang et al.   ORGANIC LETTERS

Organocatalytic atroposelective construction of axially chiral N, N- and N, S-1,2-azoles through novel ring formation approach

(2022) Yu Chang et al.   Nature Communications

The Rational Design and Atroposelective Synthesis of Axially Chiral C2‐Arylpyrrole‐Derived Amino Alcohols

(2022) Tian‐Jiao Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of Axially Chiral Indoles by Cycloaddition–Isomerization via Atroposelective Phosphoric Acid and Silver Sequential Catalysis

(2022) Yingcheng Wang et al.   ACS Catalysis

Enantioselective Synthesis of Atropisomers via Vinylidene ortho-Quinone Methides (VQMs)

(2022) Wenling Qin et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids

(2022) Nasir Tajuddeen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Atropisomerism in the Pharmaceutically Relevant Realm

(2022) Mariami Basilaia et al.   ACCOUNTS OF CHEMICAL RESEARCH

Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis

(2022) Xiao Xiao et al.   MOLECULES

N‐Heterocyclic Carbene‐Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C‐N Axial Chirality

(2021) Tingting Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalyzed Cascade Aza-Michael/Aldol Reaction for Atroposelective Construction of 4-Naphthylquinoline-3-carbaldehydes

(2021) Jing Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-Catalyzed Enantioselective Tandem C–C Bond Activation/Cacchi Reaction between Cyclobutanones and o-Ethynylanilines

(2021) Wan-Chun Yang et al.   ORGANIC LETTERS

Oxygen‐linked Cyclopentadienyl Rh(III) Complexes‐Catalyzed Asymmetric C−H Arylation of Benzo[h]quinolines with 1‐Diazonaphthoquinones

(2021) Chong-Qing Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Atroposelective Synthesis of Axially Chiral 4-Aryl α-Carbolines via N-Heterocyclic Carbene Catalysis

(2021) Rui Ma et al.   ORGANIC LETTERS

Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives

(2021) Peng-Ying Jiang et al.   Nature Communications

Atropo‐Enantioselective Oxidation‐Enabled Iridium(III)‐Catalyzed C−H Arylations with Aryl Boronic Esters

(2021) Łukasz Woźniak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Catalytic Atroposelective Construction of Pentatomic Heterobiaryl Scaffolds

(2021) Xiao‐Long He et al.   ChemCatChem

Synthesis of Atropisomers by Transition-Metal-Catalyzed Asymmetric C–H Functionalization Reactions

(2021) Chen-Xu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tandem Iridium Catalysis as a General Strategy for Atroposelective Construction of Axially Chiral Styrenes

(2021) Jie Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Atropisomeric 3-Arylindoles via Enantioselective Cacchi Reaction

(2021) Xiaojiao Li et al.   ORGANIC LETTERS

Asymmetric Synthesis of Axially Chiral Naphthyl-C3-indoles via a Palladium-Catalyzed Cacchi Reaction

(2021) Cong-Shuai Wang et al.   ORGANIC LETTERS

Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N -Aryl Indoles via Vinylidene Ortho -Quinone Methides

(2021) Da Xu et al.   CCS Chemistry

Organocatalytic Higher-Order [8+2] Cycloaddition for the Assembly of Atropoenantiomeric 3-Arylindolizines

(2021) Gongming Yang et al.   ORGANIC LETTERS

Organocatalytic atroposelective heterocycloaddition to access axially chiral 2-arylquinolines

(2021) Gongming Yang et al.   Communications Chemistry

Synthesis of Axially Chiral Biaryl-2-amines by PdII -Catalyzed Free-Amine-Directed Atroposelective C−H Olefination

(2020) Bei-Bei Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step

(2020) Seitaro Koshino et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Approach toward Chiral P,N-Chelate Complexes Utilizing the Asymmetric Hydrophosphination Protocol

(2020) Dávid Katona et al.   INORGANIC CHEMISTRY

Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C–H Arylation of Heteroarenes

(2020) Qui-Hien Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in the Catalytic Asymmetric Synthesis of Atropisomeric Hexatomic N‐Heterobiaryls

(2020) Dao-Juan Cheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Construction of Axially Chiral Indole‐Based Frameworks: An Emerging Area

(2020) Tian-Zhen Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Construction of Axially Chiral Compounds via Central‐to‐Axial Chirality Conversion

(2020) Hui Yang et al.   Chemistry-An Asian Journal

Organocatalytic Atroposelective Construction of Axially Chiral N-Aryl Benzimidazoles Involving Carbon–Carbon Bond Cleavage

(2020) Ningning Man et al.   ORGANIC LETTERS

Rhodium‐Catalyzed Atroposelective Construction of Indoles via C‐H Bond Activation

(2020) Lincong Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Phosphoric Acid: A Powerful Organocatalyst for the Asymmetric Synthesis of Heterocycles with Chiral Atropisomerism

(2020) You‐Dong Shao et al.   ChemCatChem

Enantioselective Synthesis of Atropisomers Featuring Pentatomic Heteroaromatics by Pd-Catalyzed C–H Alkynylation

(2019) Shuo Zhang et al.   ACS Catalysis

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

(2019) Yongseok Kwon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Biaryl Atropisomers via Pd-Catalyzed C-H Olefination using Chiral Spiro Phosphoric Acid Ligands

(2019) Jun Luo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation

(2019) Honghe Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction into Enantioenriched 3-Arylpyrroles

(2019) Sheng-Cai Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Barton–Zard Reaction To Access 3-Pyrrole-Containing Axially Chiral Skeletons

(2019) Xiao-Long He et al.   ACS Catalysis

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

(2019) Miaomiao Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Atroposelective Friedländer Quinoline Heteroannulation

(2019) You-Dong Shao et al.   ORGANIC LETTERS

Central‐to‐Axial Chirality Conversion Approach Designed on Organocatalytic Enantioselective Povarov Cycloadditions: First Access to Configurationally Stable Indole‐Quinoline Atropisomers

(2019) Vasco Corti et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles

(2019) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Annulation of ortho -Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-indoles

(2019) Lei Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of Atropisomeric Quinolines through the Friedländer Reaction

(2019) Junlin Wan et al.   SYNLETT

Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles

(2019) Yu-Ping He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

(2019) Brian A. Lanman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

(2018) Yong-Bin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Organocatalytic Atroposelective Intramolecular [4+2] Cycloaddition: Synthesis of Axially Chiral Heterobiaryls

(2018) Yidong Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Stereoinduction Events in One C−H Activation Step: A Route towards Terphenyl Ligands with Two Atropisomeric Axes

(2018) Quentin Dherbassy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Bird's Eye View of Atropisomers Featuring a Five-Membered Ring

(2018) Damien Bonne et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Atropisomerism in medicinal chemistry: challenges and opportunities

(2018) Sean T Toenjes et al.   Future Medicinal Chemistry

Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes

(2018) Sachie Arae et al.   ORGANIC LETTERS

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles

(2018) Sheng-Cai Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intramolecular Consecutive Dehydro-Diels-Alder Reaction for the Catalytic and Enantioselective Construction of Axial Chirality

(2018) Takanori Shibata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Cyclizative Dimerization of ( ortho ‐Alkynyl Phenyl) (Methoxymethyl) Sulfides with Palladium(II) Bisoxazoline Catalyst

(2018) Cheng Peng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

(2017) Vivek S. Raut et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal–Knorr Reaction

(2017) Lei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and Assessment of Atropisomers of (±)-Lesinurad

(2017) Jianfei Wang et al.   ACS Medicinal Chemistry Letters

Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

(2017) Yong-Bin Wang et al.   Nature Communications

Axially Chiral P,N-Ligands: Some Recent Twists and Turns

(2017) Balaji V. Rokade et al.   ACS Catalysis

Rhodium-Catalyzed Atroposelective [2 + 2 + 2] Cycloaddition of Ortho-Substituted Phenyl Diynes with Nitriles: Effect of Ortho Substituents on Regio- and Enantioselectivity

(2016) Kenichi Kashima et al.   ORGANIC LETTERS

A Dynamic Kinetic C–P Cross–Coupling for the Asymmetric Synthesis of Axially Chiral P,N Ligands

(2016) Pedro Ramírez-López et al.   ACS Catalysis

Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines

(2015) Ophélie Quinonero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C–C Bonds

(2015) Alan H. Cherney et al.   CHEMICAL REVIEWS

Catalytic Kinetic Resolution of Biaryl Compounds

(2015) Gaoyuan Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Switchable Diastereoselectivity in Enantioselective [4+2] Cycloadditions with Simple Olefins by Asymmetric Binary Acid Catalysis

(2013) Jian Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aromatic C–H coupling with hindered arylboronic acids by Pd/Fe dual catalysts

(2013) Kazuya Yamaguchi et al.   Chemical Science

Catalytic Enantioselective Synthesis of Atropisomeric Indoles with an NC Chiral Axis

(2010) Nobutaka Ototake et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a MarineStreptomycessp.

(2008) Chambers C. Hughes et al.   ORGANIC LETTERS