Role of Cell-Based Therapies in T2D

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

(2022) Diego Balboa et al.   NATURE BIOTECHNOLOGY

Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells

(2022) Audrey V. Parent et al.   Stem Cell Reports

Generation of insulin-producing pancreatic β cells from multiple human stem cell lines

(2021) Nathaniel J. Hogrebe et al.   Nature Protocols

A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion

(2021) Kisuk Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection

(2021) Audrey V. Parent et al.   Cell Reports

Treatment of type 2 diabetes: challenges, hopes, and anticipated successes

(2021) Michael A Nauck et al.   Lancet Diabetes & Endocrinology

The De-, Re-, and trans-differentiation of β-cells: Regulation and function

(2020) Jingjing Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

(2020) Angelica Artasensi et al.   MOLECULES

Current status of porcine islet xenotransplantation

(2020) Taylor M. Coe et al.   Current Opinion in Organ Transplantation

Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy

(2020) Gopika G. Nair et al.   Nature Reviews Endocrinology

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

(2020) Matteo Apicella et al.   Lancet Diabetes & Endocrinology

Subtypes of Type 2 Diabetes Determined From Clinical Parameters

(2020) Emma Ahlqvist et al.   DIABETES

Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes

(2020) Marika Falcone et al.   Frontiers in Endocrinology

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depression prevalence in Type 2 diabetes is not related to diabetes–depression symptom overlap but is related to symptom dimensions within patient self‐report measures: a meta‐analysis

(2019) K. A. Harding et al.   DIABETIC MEDICINE

Designing cell function: assembly of synthetic gene circuits for cell biology applications

(2018) Mingqi Xie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

β Cell Replacement Therapy

(2018) Christian Schuetz et al.   TRANSPLANTATION

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

Interspecies organogenesis generates autologous functional islets

(2017) Tomoyuki Yamaguchi et al.   NATURE

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Novel factors modulating human β-cell proliferation

(2016) J. Shirakawa et al.   DIABETES OBESITY & METABOLISM

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

(2016) Abd A. Tahrani et al.   Nature Reviews Endocrinology

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2016) Yong-chao Qiao et al.   Journal of Diabetes Research

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Pig-to-Monkey Islet Xenotransplantation Using Multi-Transgenic Pigs

(2014) R. Bottino et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Changes in Diabetes-Related Complications in the United States, 1990–2010

(2014) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY