Generation of insulin-producing pancreatic β cells from multiple human stem cell lines

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

(2020) Pallavi U. Mahaddalkar et al.   NATURE BIOTECHNOLOGY

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

(2020) Kristina G. Maxwell et al.   Science Translational Medicine

Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy

(2020) Gopika G. Nair et al.   Nature Reviews Endocrinology

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

(2020) Leonardo Velazco-Cruz et al.   Frontiers in Bioengineering and Biotechnology

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

(2020) Punn Augsornworawat et al.   Cell Reports

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

(2019) Esther Latres et al.   Cell Metabolism

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

(2019) Nadav Sharon et al.   Cell Reports

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

Mimicking nature-made beta cells

(2019) Daniel M. Tremmel et al.   Current Opinion in Organ Transplantation

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

(2019) Juan R. Alvarez-Dominguez et al.   Cell Stem Cell

LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State

(2019) Xin Zhou et al.   Stem Cell Reports

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

(2018) Julie B. Sneddon et al.   Cell Stem Cell

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

(2017) Kathryn F. Cogger et al.   Nature Communications

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds

(2016) James D. Johnson   DIABETOLOGIA

Long-Term Follow-Up of the Edmonton Protocol of Islet Transplantation in the United States

(2015) D. C. Brennan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Toward beta cell replacement for diabetes

(2015) B. Johannesson et al.   EMBO JOURNAL

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme

(2012) Julie B. Sneddon et al.   NATURE

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine

(2012) Maria Cristina Nostro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

(2011) Yuya Kunisada et al.   Stem Cell Research

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY