Heterochronic Plasma Transfer: Experimental Design, Considerations, and Technical Challenges

Cancer statistics, 2023

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Blood-to-brain communication in aging and rejuvenation

(2023) Gregor Bieri et al.   NATURE NEUROSCIENCE

Biological age is increased by stress and restored upon recovery

(2023) Jesse R. Poganik et al.   Cell Metabolism

Performance Validation of Three Scoring Systems for the Prediction of Thrombotic Microangiopathy Due to Severe ADAMTS13 Deficiency and the Response to Therapeutic Plasma Exchange: First Study in Korea

(2023) Sang Hyuk Park et al.   Annals of Laboratory Medicine

Research priorities for therapeutic plasma exchange in critically ill patients

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Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

(2022) Shuai Ma et al.   Cell Stem Cell

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

(2022) Róbert Pálovics et al.   NATURE

The effect of young blood plasma administration on gut microbiota in middle-aged rats

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Cell Non-autonomous Proteostasis Regulation in Aging and Disease

(2022) Joao Vasco Ferreira et al.   Frontiers in Neuroscience

Small-animal blood exchange is an emerging approach for systemic aging research

(2022) Melod Mehdipour et al.   Nature Protocols

Heterochronic blood exchange attenuates age-related neuroinflammation and confers cognitive benefits: do microvascular protective effects play a role?

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A technical note on contamination from PRF tubes containing silica and silicone

(2021) Richard J. Miron et al.   BMC Oral Health

Assembly and operation of an easy-to-make portable device for facilitating mouse lateral tail-vein injection

(2021) Qi Wu et al.   LAB ANIMAL

Exercise plasma boosts memory and dampens brain inflammation via clusterin

(2021) Zurine De Miguel et al.   NATURE

Acute cytotoxic effects of silica microparticles used for coating of plastic blood-collection tubes on human periosteal cells

(2020) Hideo Masuki et al.   Odontology

Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

(2020) Melod Mehdipour et al.   Aging-US

Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice

(2020) Tae-Woon Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Review of Rodent Euthanasia Methods

(2020) Nirah H Shomer et al.   Journal of the American Association for Laboratory Animal Science

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

(2020) Matthew J. Yousefzadeh et al.   GeroScience

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

(2020) Alana M. Horowitz et al.   SCIENCE

Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice

(2020) Ying Zhao et al.   Alzheimers Research & Therapy

Circulating plasma factors involved in rejuvenation

(2020) Jae Sook Kang et al.   Aging-US

Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice

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Plasma from Young Rats Injected into Old Rats Induce Antiaging Effects

(2020) Shambhoo Sharan Tripathi et al.   REJUVENATION RESEARCH

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

(2020) Melod Mehdipour et al.   GeroScience

Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage

(2019) Jun-Jie Yuan et al.   BIOSCIENCE REPORTS

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Research Techniques Made Simple: Parabiosis to Elucidate Humoral Factors in Skin Biology

(2019) Casey A. Spencer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasma-Based Strategies for Therapeutic Modulation of Brain Aging

(2019) Viktoria Kheifets et al.   Neurotherapeutics

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?

(2019) Abdullah Al Shoyaib et al.   PHARMACEUTICAL RESEARCH

Impact assessment of tail-vein injection in mice using a modified anaesthesia induction chamber versus a common restrainer without anaesthesia

(2018) Marlene Resch et al.   LABORATORY ANIMALS

Adipose tissue senescence and inflammation in aging is reversed by the young milieu

(2018) Amiya Kumar Ghosh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice

(2018) Ceren Ozek et al.   Scientific Reports

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study

(2018) Sharon J. Sha et al.   JAMA Neurology

Optimization of pure platelet-rich plasma preparation: A comparative study of pure platelet-rich plasma obtained using different centrifugal conditions in a single-donor model

(2017) Wenjing Yin et al.   Experimental and Therapeutic Medicine

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

(2016) Jinte Middeldorp et al.   JAMA Neurology

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection

(2015) Peter Toth et al.   AGING CELL

Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice

(2015) Linjie Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vital signs monitoring during injectable and inhalant anesthesia in mice

(2015) Atsushi TSUKAMOTO et al.   EXPERIMENTAL ANIMALS

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

(2015) S. F. Leiser et al.   SCIENCE

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

Blood-Borne Revitalization of the Aged Brain

(2015) Joseph M. Castellano et al.   JAMA Neurology

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

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Minimally Invasive Monitoring of Chronic Central Venous Catheter Patency in Mice Using Digital Subtraction Angiography (DSA)

(2015) Giovanna Figueiredo et al.   PLoS One

Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice

(2014) Katsutaka Oishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurologic indications for therapeutic plasma exchange: 2013 update

(2014) Kelly Gwathmey et al.   JOURNAL OF CLINICAL APHERESIS

Aging and brain rejuvenation as systemic events

(2014) Jill Bouchard et al.   JOURNAL OF NEUROCHEMISTRY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

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Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

(2013) Michael J. Conboy et al.   AGING CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Parabiosis in Mice: A Detailed Protocol

(2013) Paniz Kamran et al.   Jove-Journal of Visualized Experiments

Retro-orbital injections in mice

(2011) Tal Yardeni et al.   LAB ANIMAL

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction

(2009) Emanuele Marzetti et al.   BIOFACTORS

Angiogenic properties of sustained release platelet-rich plasma: Characterization in-vitro and in the ischemic hind limb of the mouse

(2009) Shyamal Chandra Bir et al.   JOURNAL OF VASCULAR SURGERY

Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model

(2007) Christina D. Steel et al.   LAB ANIMAL