Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

(2020) Matthew J. Yousefzadeh et al.   AGING CELL

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

(2019) Prashanti Patil et al.   AGING CELL

Raman fingerprints as promising markers of cellular senescence and aging

(2019) Lisa Liendl et al.   GeroScience

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Astrocyte senescence contributes to cognitive decline

(2019) Tamas Csipo et al.   GeroScience

circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan

(2019) Shahnaz Haque et al.   GeroScience

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16INK4a

(2018) Ibiyonu Lawrence et al.   GeroScience

A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence

(2018) Kaitlyn N. Lewis et al.   GeroScience

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

A New Preclinical Paradigm for Testing Anti-Aging Therapeutics

(2017) Warren Ladiges et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin

(2017) Shafaat Y. Khan et al.   Scientific Reports

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Systemic Problems: A perspective on stem cell aging and rejuvenation

(2015) Irina M. Conboy et al.   Aging-US

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging

(2015) Warren Ladiges et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

(2015) Hanadie Yousef et al.   Oncotarget

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses

(2009) Morgan E. Carlson et al.   AGING CELL

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Molecular aging and rejuvenation of human muscle stem cells

(2009) Morgan E. Carlson et al.   EMBO Molecular Medicine