Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside

Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis

(2016) Dede K.W. Man et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

Intratracheal Administration of Small Interfering RNA Targeting Fas Reduces Lung Ischemia-Reperfusion Injury*

(2016) Lorenzo Del Sorbo et al.   CRITICAL CARE MEDICINE

Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice

(2016) Jens Lipka et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis

(2016) Pyoung Oh Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary administration of small interfering RNA: The route to go?

(2016) M.J.R. Ruigrok et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

(2016) Yuran Xie et al.   JOURNAL OF CONTROLLED RELEASE

Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems

(2016) Susanne R. Youngren-Ortiz et al.   KONA Powder and Particle Journal

Investigating The Value Of Omalizumab In The Treatment Of Severe Persistent Allergic Asthma: A Systematic Review Of Cost-Effectiveness Studies

(2016) N Likhar et al.   VALUE IN HEALTH

Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

(2015) Dan Shu et al.   ACS Nano

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Expression of a single siRNA against a conserved region of NP gene strongly inhibits in vitro replication of different Influenza A virus strains of avian and swine origin

(2015) Elena Stoppani et al.   ANTIVIRAL RESEARCH

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

(2015) Yuran Xie et al.   ARCHIV DER PHARMAZIE

Developing an effective therapeutic by delivery of synthetic microRNA-520e in lung cancer treatment

(2015) Dedong Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Nanomedicine as an emerging platform for metastatic lung cancer therapy

(2015) Dalit Landesman-Milo et al.   CANCER AND METASTASIS REVIEWS

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

(2015) Elisa Parra et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Dry Powder Formulation of Plasmid DNA and siRNA for Inhalation

(2015) Michael Chow et al.   CURRENT PHARMACEUTICAL DESIGN

Barrier or carrier? Pulmonary surfactant and drug delivery

(2015) Alberto Hidalgo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies

(2015) Hua Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of Small RNA Delivery Systems for Lung Cancer Therapy

(2015) Yu Fujita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bio-inspired pulmonary surfactant-modified nanogels: A promising siRNA delivery system

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

(2015) Jared M. McLendon et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of chemosensitizing siRNA and an anticancer agent via multiple monocomplexation-induced hydrophobic association

(2015) Eunjung Lee et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection

(2015) Jin Kyung Kim et al.   JOURNAL OF IMMUNOLOGY

Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus

(2015) Wanling Liang et al.   MOLECULAR PHARMACEUTICS

Autophagy is not the answer

(2015) Samuel M. Behar et al.   NATURE

Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung

(2015) Daisuke Ihara et al.   PHARMACEUTICAL RESEARCH

Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer

(2015) Caina Xu et al.   Small

A systematic review of the clinical effectiveness of first-line chemotherapy for adult patients with locally advanced or metastatic non-small cell lung cancer

(2015) G. Pilkington et al.   THORAX

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer

(2015) Yu Fujita et al.   Oncotarget

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

(2015) Christopher E Brightling et al.   Lancet Respiratory Medicine

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

Tracking and treating activated T cells

(2015) N.H. Kim et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Adamantane-Resistant Influenza A Viruses in the World (1902–2013): Frequency and Distribution of M2 Gene Mutations

(2015) Guoying Dong et al.   PLoS One

siRNA Delivery to the lung: What's new?

(2014) Olivia M. Merkel et al.   ADVANCED DRUG DELIVERY REVIEWS

Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2014) M. Reck et al.   ANNALS OF ONCOLOGY

Targeted Small Interfering RNA-Immunoliposomes as a Promising Therapeutic Agent against Highly Pathogenic Avian Influenza A (H5N1) Virus Infection

(2014) K. Khantasup et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

(2014) Li Li et al.   BIOMATERIALS

Novel drugs against tuberculosis: a clinician's perspective

(2014) Ioana Diana Olaru et al.   EUROPEAN RESPIRATORY JOURNAL

Aerosol gene delivery using viral vectors and cationic carriers forin vivolung cancer therapy

(2014) Seong-Ho Hong et al.   Expert Opinion on Drug Delivery

RNA-based drugs and vaccines

(2014) Kenneth Lundstrom   Expert Review of Vaccines

Small Interfering RNAs Targeted to Interleukin-4 and Respiratory Syncytial Virus Reduce Airway Inflammation in a Mouse Model of Virus-Induced Asthma Exacerbation

(2014) Musa R. Khaitov et al.   HUMAN GENE THERAPY

Nanoparticle-Mediated Pulmonary Drug Delivery: A Review

(2014) Mukta Paranjpe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

siRNA-Based Therapies for Pulmonary Diseases

(2014) Uday Koli et al.   Journal of Biomedical Nanotechnology

Peptides Used in the Delivery of Small Noncoding RNA

(2014) Ravi S. Shukla et al.   MOLECULAR PHARMACEUTICS

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

(2014) Da Ma   Nanoscale

The COPD pipeline

(2014) Yasser Mushtaq   NATURE REVIEWS DRUG DISCOVERY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis

(2014) S. L. Ralston et al.   PEDIATRICS

Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6

(2014) Gareth D. Healey et al.   PLoS One

RETRACTED ARTICLE: MicroRNA-495 mimics delivery inhibits lung tumor progression

(2014) Cheng Ai et al.   TUMOR BIOLOGY

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

Asthma: pathogenesis and novel drugs for treatment

(2014) J. T. Olin et al.   BMJ-British Medical Journal

Modifiers of TGF-β1 effector function as novel therapeutic targets of pulmonary fibrosis

(2014) Chang-Min Lee et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

MicroRNA-326 Regulates Profibrotic Functions of Transforming Growth Factor-β in Pulmonary Fibrosis

(2013) Sudipta Das et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influenza virus resistance to neuraminidase inhibitors

(2013) Mélanie Samson et al.   ANTIVIRAL RESEARCH

Gene Silencing in a Mouse Lung Metastasis Model by an Inhalable Dry Small Interfering RNA Powder Prepared Using the Supercritical Carbon Dioxide Technique

(2013) Tomoyuki Okuda et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models

(2013) João Conde et al.   BIOMATERIALS

Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy

(2013) Cuifang Zheng et al.   BIOMATERIALS

Acute lung injury

(2013) D. Parekh et al.   CLINICAL MEDICINE

Respiratory Syncytial Virus—A Comprehensive Review

(2013) Andrea T. Borchers et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Recent advances in pre-clinical mouse models of COPD

(2013) Ross Vlahos et al.   CLINICAL SCIENCE

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

(2013) Wanling Liang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Lentivirus-AIMP2-DX2 shRNA Suppresses Cell Proliferation by Regulating Akt1 Signaling Pathway in the Lungs of AIMP2+/– Mice

(2013) Soon-Kyung Hwang et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA

(2013) Oleh Taratula et al.   JOURNAL OF CONTROLLED RELEASE

Combined delivery of HMGB-1 box A peptide and S1PLyase siRNA in animal models of acute lung injury

(2013) Binna Oh et al.   JOURNAL OF CONTROLLED RELEASE

VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis

(2013) Seyedtaghi Takyar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-Induced Death Signaling Triggers Alveolar Epithelial Dysfunction in Acute Lung Injury

(2013) B. V. Patel et al.   JOURNAL OF IMMUNOLOGY

Receptor-Interacting Protein 2 Gene Silencing Attenuates Allergic Airway Inflammation

(2013) F. Y. Goh et al.   JOURNAL OF IMMUNOLOGY

Bacterial Complications of Respiratory Tract Viral Illness: A Comprehensive Evaluation

(2013) A. R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels

(2013) Lynn De Backer et al.   Nanomedicine

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Knockdown of the Sodium-Dependent Phosphate Co-Transporter 2b (NPT2b) Suppresses Lung Tumorigenesis

(2013) Seong-Ho Hong et al.   PLoS One

Strategic priorities for respiratory syncytial virus (RSV) vaccine development

(2013) L.J. Anderson et al.   VACCINE

Polyethylenimines for siRNA and miRNA delivery in vivo

(2013) Sabrina Höbel et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A novel platform to enable inhaled naked RNAi medicine for lung cancer

(2013) Yu Fujita et al.   Scientific Reports

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

(2013) Jinli Wang et al.   PLoS Pathogens

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

(2012) Sandy B. Hartono et al.   ACS Nano

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The promise, pitfalls and progress of RNA-interference-based antiviral therapy for respiratory viruses

(2012) John P DeVincenzo   ANTIVIRAL THERAPY

Noncovalenly PEGylated CTGF siRNA/PDMAEMA complex for pulmonary treatment of bleomycin-induced lung fibrosis

(2012) Dong Kyung Sung et al.   BIOMATERIALS

A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics

(2012) Peter Hodsman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

MicroRNA-199a-5p Is Associated With Hypoxia-Inducible Factor-1α Expression in Lungs From Patients With COPD

(2012) Shiro Mizuno et al.   CHEST

The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?

(2012) Mayra Silva Miranda et al.   Clinical & Developmental Immunology

In Vivo Delivery Aspects of miRNA, shRNA and siRNA

(2012) N. I. Khatri et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Pseudotyped Adeno-Associated Virus 2/9-Delivered CCL11 shRNA Alleviates Lung Inflammation in an Allergen-Sensitized Mouse Model

(2012) Chia-Jen Wu et al.   HUMAN GENE THERAPY

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

(2012) Yang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

On the cellular processing of non-viral nanomedicines for nucleic acid delivery: Mechanisms and methods

(2012) Dries Vercauteren et al.   JOURNAL OF CONTROLLED RELEASE

Lipid-based vectors for siRNA delivery

(2012) Shubiao Zhang et al.   JOURNAL OF DRUG TARGETING

Effect of locally administered Syk siRNA on allergen-induced arthritis and asthma

(2012) Zhen-Yu Huang et al.   MOLECULAR IMMUNOLOGY

Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles

(2012) Christian Mueller et al.   MOLECULAR THERAPY

In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

(2012) Yuan Zhang et al.   MOLECULAR THERAPY

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

The Role and Source of Tumor Necrosis Factor-α in Hemorrhage-Induced Priming for Septic Lung Injury

(2012) Joanne Lomas-Neira et al.   SHOCK

Pulmonary delivery of therapeutic siRNA

(2011) Jenny Ka-Wing Lam et al.   ADVANCED DRUG DELIVERY REVIEWS

Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 Short Interfering RNAs for Pulmonary Fibrosis

(2011) Corina N. D'Alessandro-Gabazza et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes

(2011) Dries Vercauteren et al.   BIOMATERIALS

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

The potential use of tyrosine kinase inhibitors in severe asthma

(2011) Vamsi P. Guntur et al.   Current Opinion in Allergy and Clinical Immunology

Cellular uptake mechanism and knockdown activity of siRNA-loaded biodegradable DEAPA-PVA-g-PLGA nanoparticles

(2011) Markus Benfer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of particle size on regional lung deposition – What evidence is there?

(2011) Thiago C. Carvalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Let-7 microRNA–mediated regulation of IL-13 and allergic airway inflammation

(2011) Manish Kumar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA

(2011) Saurabh Singh et al.   PHARMACEUTICAL RESEARCH

Gene expression networks in COPD: microRNA and mRNA regulation

(2011) Michael E Ezzie et al.   THORAX

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

(2011) Adrian G. Rosas-Taraco et al.   TUBERCULOSIS

Pathogenesis of indirect (secondary) acute lung injury

(2011) Mario Perl et al.   Expert Review of Respiratory Medicine

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protection of LPS-Induced Murine Acute Lung Injury by Sphingosine-1-Phosphate Lyase Suppression

(2010) Yutong Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Clinical status of duplex RNA

(2010) Jonathan K. Watts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Viral vector-mediated RNA interference

(2010) Linda B Couto et al.   CURRENT OPINION IN PHARMACOLOGY

Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung

(2010) Melanie Günther et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting

(2010) Noha M Zaki et al.   Expert Opinion on Drug Delivery

Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages

(2010) Mahesh Kathania et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Role of viral respiratory infections in asthma and asthma exacerbations

(2010) William W Busse et al.   LANCET

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Approval Summary: Erlotinib Maintenance Therapy of Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

(2010) M. H. Cohen et al.   ONCOLOGIST

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

(2010) Jiu-Cun Wang et al.   ARTHRITIS RESEARCH & THERAPY

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

(2009) Koen Raemdonck et al.   ADVANCED FUNCTIONAL MATERIALS

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

(2009) R. Alvarez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Tat-BMPs-PAMAM Conjugates Enhance Therapeutic Effect of Small Interference RNA on U251 Glioma Cells In Vitro and In Vivo

(2009) Lei Han et al.   HUMAN GENE THERAPY

Acute Lung Injury Review

(2009) Kenji Tsushima et al.   INTERNAL MEDICINE

Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice

(2009) Y. Darcan-Nicolaisen et al.   JOURNAL OF IMMUNOLOGY

Regulation of Airway MUC5AC Expression by IL-1  and IL-17A; the NF- B Paradigm

(2009) T. Fujisawa et al.   JOURNAL OF IMMUNOLOGY

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small Interfering RNA Targeting M2 Gene Induces Effective and Long Term Inhibition of Influenza A Virus Replication

(2009) Hong-Yan Sui et al.   PLoS One

Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells

(2009) Alex M. Chen et al.   Small

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

(2009) Kittipong Maneechotesuwan et al.   PLOS MEDICINE

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Intrapulmonary Delivery of XCL1-Targeting Small Interfering RNA in Mice Chronically Infected withMycobacterium tuberculosis

(2008) Adrian G. Rosas-Taraco et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids

(2008) K ZHOU et al.   JOURNAL OF BIOTECHNOLOGY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

RPN2 gene confers docetaxel resistance in breast cancer

(2008) Kimi Honma et al.   NATURE MEDICINE

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

(2008) Michael R. Edwards et al.   PHARMACOLOGY & THERAPEUTICS

Structure and Function of the Polymeric Mucins in Airways Mucus

(2007) David J. Thornton et al.   Annual Review of Physiology

Lentiviral-mediated GATA-3 RNAi Decreases Allergic Airway Inflammation and Hyperresponsiveness

(2007) Chen-Chen Lee et al.   MOLECULAR THERAPY