Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA

Small Interfering RNAs Induce Macrophage Migration Inhibitory Factor Production and Proliferation in Breast Cancer Cells via a Double-Stranded RNA-Dependent Protein Kinase-Dependent Mechanism

(2014) M. E. Armstrong et al.   JOURNAL OF IMMUNOLOGY

Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo

(2011) Richeng Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Galactose-Modified Cationic Liposomes as a Liver-Targeting Delivery System for Small Interfering RNA

(2011) Satoru Sonoke et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dual mode polyspermine with tunable degradability for plasmid DNA and siRNA delivery

(2011) Min Suk Shim et al.   BIOMATERIALS

A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons

(2011) Ye Han et al.   BRAIN RESEARCH

Improving siRNA Bio-Distribution and Minimizing Side Effects

(2011) Bruna Scaggiante et al.   CURRENT DRUG METABOLISM

FRET-based probing to gain direct information on siRNA sustainability in live cells: Asymmetric degradation of siRNA strands

(2011) Seonmi Shin et al.   Molecular BioSystems

Single-particle Tracking as a Quantitative Microscopy-based Approach to Unravel Cell Entry Mechanisms of Viruses and Pharmaceutical Nanoparticles

(2011) Nadia Ruthardt et al.   MOLECULAR THERAPY

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

PEI-g-PEG-RGD/Small Interference RNA Polyplex-Mediated Silencing of Vascular Endothelial Growth Factor Receptor and Its Potential as an Anti-Angiogenic Tumor Therapeutic Strategy

(2011) Jihoon Kim et al.   OLIGONUCLEOTIDES

GFAP Promoter-Driven RNA Interference on TGF-β1 to Treat Liver Fibrosis

(2011) Ningning Yang et al.   PHARMACEUTICAL RESEARCH

miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors

(2011) Espen Enerly et al.   PLoS One

Global MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer

(2011) Françoise Rothé et al.   PLoS One

siRNA-Like Double-Stranded RNAs Are Specifically Protected Against Degradation in Human Cell Extract

(2011) John A. H. Hoerter et al.   PLoS One

A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity

(2011) Yang Feng et al.   ARTHRITIS RESEARCH & THERAPY

Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target

(2011) Adam Collison et al.   BMC Pulmonary Medicine

RNAi-Based Treatment for Neovascular Age-Related Macular Degeneration by Sirna-027

(2010) Peter K. Kaiser et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Detection of microRNAs in dried serum blots

(2010) Santosh Kumar Patnaik et al.   ANALYTICAL BIOCHEMISTRY

Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation

(2010) Ravikiran Panakanti et al.   BIOCHEMICAL PHARMACOLOGY

Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation

(2010) Lin Zhu et al.   BIOCONJUGATE CHEMISTRY

Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate

(2010) Seok Ki Choi et al.   CHEMICAL COMMUNICATIONS

Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles

(2010) H. D. Han et al.   CLINICAL CANCER RESEARCH

Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung

(2010) Melanie Günther et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems

(2010) Miriam Rothdiener et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of therapeutic shRNA and siRNA by Tat fusion peptide targeting bcr–abl fusion gene in Chronic Myeloid Leukemia cells

(2010) Yamini Arthanari et al.   JOURNAL OF CONTROLLED RELEASE

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing

(2010) Walter R. Strapps et al.   NUCLEIC ACIDS RESEARCH

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

(2009) Tamaki Endoh et al.   ADVANCED DRUG DELIVERY REVIEWS

Efficient Short Interference RNA Delivery to Tumor Cells Using a Combination of Octaarginine, GALA and Tumor-Specific, Cleavable Polyethylene Glycol System

(2009) Yu Sakurai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Sequence determinants of innate immune activation by short interfering RNAs

(2009) Amber Goodchild et al.   BMC IMMUNOLOGY

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

(2009) Hiroto Hatakeyama et al.   JOURNAL OF CONTROLLED RELEASE

Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene

(2009) Feng Li et al.   JOURNAL OF GENE MEDICINE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Structural insights into RNA processing by the human RISC-loading complex

(2009) Hong-Wei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs

(2009) Q. Ge et al.   RNA

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

MicroRNAs: A new class of gene regulators

(2008) Douglas J. Guarnieri et al.   ANNALS OF MEDICINE

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Novel Biodegradable Poly(disulfide amine)s for Gene Delivery with High Efficiency and Low Cytotoxicity

(2008) Mei Ou et al.   BIOCONJUGATE CHEMISTRY

Structural and Formulation Factors Influencing Pyridinium Lipid-Based Gene Transfer

(2008) Lin Zhu et al.   BIOCONJUGATE CHEMISTRY

PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumor progression with reduced toxicity and immunogenicity

(2008) Jie Gao et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes

(2008) Satoru Sonoke et al.   CANCER RESEARCH

Overcoming the Innate Immune Response to Small Interfering RNA

(2008) Adam Judge et al.   HUMAN GENE THERAPY

Delivery of siRNA mediated by histidine-containing reducible polycations

(2008) Mark Stevenson et al.   JOURNAL OF CONTROLLED RELEASE

Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo

(2008) Miriam Breunig et al.   JOURNAL OF CONTROLLED RELEASE

Caspase-3 Gene Silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets

(2008) Guofeng Cheng et al.   MOLECULAR PHARMACEUTICS

Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic

(2008) Jeffery C Giering et al.   MOLECULAR THERAPY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells

(2008) Thomas Ohrt et al.   NUCLEIC ACIDS RESEARCH

Direct CNS Delivery of siRNA Mediates Robust Silencing in Oligodendrocytes

(2008) William Querbes et al.   OLIGONUCLEOTIDES

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

(2008) Laura Fontana et al.   PLoS One

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE

An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus

(2008) S. Guang et al.   SCIENCE

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

(2007) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE