Current progress of siRNA/shRNA therapeutics in clinical trials

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HIV Status Does Not Affect the Outcome of Autologous Stem Cell Transplantation (ASCT) for Non-Hodgkin Lymphoma (NHL)

(2010) Amrita Krishnan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Clinical status of duplex RNA

(2010) Jonathan K. Watts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference

(2010) D D Rao et al.   CANCER GENE THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-targeting siRNAs

(2010) K. Tiemann et al.   RNA

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

RNAi and small interfering RNAs in human disease therapeutic applications

(2010) Monica R. Lares et al.   TRENDS IN BIOTECHNOLOGY

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

(2009) R. Alvarez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Harnessing RNA interference to develop neonatal therapies: From Nobel Prize winning discovery to proof of concept clinical trials

(2009) John P. DeVincenzo   EARLY HUMAN DEVELOPMENT

RNAi-based therapeutics-current status, challenges and prospects

(2009) Katrin Tiemann et al.   EMBO Molecular Medicine

Stem cells, ribozymes and HIV

(2009) J C Burnett et al.   GENE THERAPY

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder

(2009) Sancy A Leachman et al.   MOLECULAR THERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Expression Strategies for Short Hairpin RNA Interference Triggers

(2008) John J. Rossi   HUMAN GENE THERAPY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Silencing of Polo-Like Kinase (Plk) 1 via siRNA Causes Inhibition of Growth and Induction of Apoptosis in Human Esophageal Cancer Cells

(2008) Youquan Bu et al.   ONCOLOGY

Single-Nucleotide-Specific siRNA Targeting in a Dominant-Negative Skin Model

(2007) Robyn P. Hickerson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY