Berberine ameliorates contrast‐induced acute kidney injury by regulating HDAC4‐FoxO3a axis‐induced autophagy: In vivo and in vitro

Kaempferide ameliorates cisplatin-induced nephrotoxicity via inhibiting oxidative stress and inducing autophagy

(2023) Yan-fei Shao et al.   ACTA PHARMACOLOGICA SINICA

Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes

(2022) Saravanan Kandasamy et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62‐Keap1‐Nrf2 signaling pathway

(2022) Yi Zhang et al.   PHYTOTHERAPY RESEARCH

Contrast-Associated Acute Kidney Injury: Advances and Challenges

(2022) Qingqing Li et al.   International Journal of General Medicine

Several Alkaloids in Chinese Herbal Medicine Exert Protection in Acute Kidney Injury: Focus on Mechanism and Target Analysis

(2022) Yixin Rui et al.   Oxidative Medicine and Cellular Longevity

Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling

(2022) Xue Zhu et al.   Frontiers in Oncology

Class IIa histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation

(2022) Jialu Li et al.   Frontiers in Pharmacology

Pharmacological and Genetic Inhibition of HDAC4 Alleviates Renal Injury and Fibrosis in Mice

(2022) Fengchen Shen et al.   Frontiers in Pharmacology

The protection afforded by Berberine against chemotherapy‐mediated nephropathy in rats involves regulation of the antioxidant axis

(2022) Reham I. Alagal et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury via SIRT6-Mediated Autophagy Activation

(2022) Zhen Li et al.   Oxidative Medicine and Cellular Longevity

Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1‐ErbB2‐PI3K‐AKT pathway in diabetic peripheral neuropathy mice

(2022) Xiaobao Gong et al.   PHYTOTHERAPY RESEARCH

Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

(2021) Mian Wu et al.   Disease Models & Mechanisms

αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy

(2021) Xuying Zhu et al.   PHARMACOLOGICAL RESEARCH

NQO1 Deficiency Aggravates Renal Injury by Dysregulating Vps34/ATG14L Complex during Autophagy Initiation in Diabetic Nephropathy

(2021) Geum-Lan Hong et al.   Antioxidants

Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c/caspase3/HDAC4 pathway

(2021) Yi-fei Liu et al.   ACTA PHARMACOLOGICA SINICA

Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma

(2021) Katharina Körholz et al.   Cells

Downregulation of miR ‐29b‐3p aggravates podocyte injury by targeting HDAC4 in LPS ‐induced acute kidney injury

(2021) Zong‐Lan Ha et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3

(2021) Chunmei Zhang et al.   Oxidative Medicine and Cellular Longevity

Berberine Acts on C/EBPβ/lncRNA Gas5/miR-18a-5p Loop to Decrease the Mitochondrial ROS Generation in HK-2 Cells

(2021) Jiang Xu et al.   Frontiers in Endocrinology

Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α / XBP1 pathway

(2021) Xueying Zhang et al.   PHYTOTHERAPY RESEARCH

The protective impact of berberine against doxorubicin-induced nephrotoxicity in rats

(2021) Ghadha Ibrahim Fouad et al.   TISSUE & CELL

Autophagy Function and Regulation in Kidney Disease

(2020) Gur P. Kaushal et al.   Biomolecules

Highly bioavailable berberine formulation ameliorates diabetic nephropathy through the inhibition of glomerular mesangial matrix expansion and the activation of autophagy

(2020) Meishuang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histone Deacetylases in Kidney Physiology and Acute Kidney Injury

(2020) Kelly A. Hyndman   SEMINARS IN NEPHROLOGY

Advances in the pathogenesis and prevention of contrast-induced nephropathy

(2020) Fangfei Zhang et al.   LIFE SCIENCES

Preventing contrast‐induced nephropathy ( CIN ) with herbal medicines: A review

(2020) Motahareh Boozari et al.   PHYTOTHERAPY RESEARCH

Berberine alleviates cisplatin-induced acute kidney injury by regulating mitophagy via PINK 1/Parkin pathway

(2020) Jieying Qi et al.   Translational Andrology and Urology

The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction

(2020) Liangpeng Li et al.   EUROPEAN HEART JOURNAL

A review on pain‐relieving activity of berberine

(2020) Mahmoud Hashemzaei et al.   PHYTOTHERAPY RESEARCH

Integrated Analysis of m6A Methylome in Cisplatin-Induced Acute Kidney Injury and Berberine Alleviation in Mouse

(2020) Jianxiao Shen et al.   Frontiers in Genetics

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis

(2019) Chongxiang Xiong et al.   FASEB JOURNAL

MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4

(2019) Hongkun Wu et al.   Autophagy

Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin

(2019) Li Li Han et al.   MOLECULAR CANCER RESEARCH

Quercetin protects against cisplatin‐induced acute kidney injury by inhibiting Mincle/Syk/NF‐κB signaling maintained macrophage inflammation

(2019) Rui‐Zhi Tan et al.   PHYTOTHERAPY RESEARCH

The FoxO–Autophagy Axis in Health and Disease

(2019) Zhiyong Cheng   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat

(2019) Aziz Eftekhari et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model

(2018) Wei Cheng et al.   ARCHIVES OF TOXICOLOGY

HDAC4 regulates vascular inflammation via activation of autophagy

(2018) Di Yang et al.   CARDIOVASCULAR RESEARCH

Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2

(2018) Haiya Zheng et al.   Experimental and Therapeutic Medicine

The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

(2018) Emad H.M. Hassanein et al.   BIOMEDICINE & PHARMACOTHERAPY

Glomerular mesangial cell and podocyte injuries in diabetic nephropathy

(2018) Chun-Wu Tung et al.   NEPHROLOGY

Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes

(2017) Yingli Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line

(2016) Arunachalam Kalaiarasi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

(2016) Mohammad Adil et al.   RENAL FAILURE

Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin

(2015) Fei Yue et al.   Aging-US

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

Radiocontrast-induced nephropathy is attenuated by autophagy through regulation of apoptosis and inflammation

(2015) Gang Jee Ko et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy

(2014) Qingqing Wei et al.   KIDNEY INTERNATIONAL

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy

(2014) Xiaojie Wang et al.   KIDNEY INTERNATIONAL

Acute toxicity of berberine and its correlation with the blood concentration in mice

(2010) Michael M. Kheir et al.   FOOD AND CHEMICAL TOXICOLOGY