Pharmacological and Genetic Inhibition of HDAC4 Alleviates Renal Injury and Fibrosis in Mice

Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences

(2021) Sara Panizo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic modifications of Klotho expression in kidney diseases

(2021) Jinkun Xia et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target

(2021) Chun Cheng et al.   Cell Death & Disease

The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury

(2021) Xun Zhou et al.   Frontiers in Pharmacology

Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets

(2021) José Alberto Navarro-García et al.   Frontiers in Physiology

Diverse Role of TGF-β in Kidney Disease

(2020) Yue-Yu Gu et al.   Frontiers in Cell and Developmental Biology

Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis

(2020) Yunhe Zhang et al.   FASEB JOURNAL

Targeting the progression of chronic kidney disease

(2020) Marta Ruiz-Ortega et al.   Nature Reviews Nephrology

Epigenetic and non-epigenetic regulation of Klotho in kidney disease

(2020) Ajinath Kale et al.   LIFE SCIENCES

New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2020) Lili Sheng et al.   Frontiers in Physiology

Kidney disease in the Global Burden of Disease Study 2017

(2019) Simon D. S. Fraser et al.   Nature Reviews Nephrology

Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis

(2019) Chongxiang Xiong et al.   FASEB JOURNAL

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments

(2019) Elena Martínez-Klimova et al.   Biomolecules

The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling

(2018) Petros Andrikopoulos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HDAC4 stimulates MRTF-A expression and drives fibrogenesis in hepatic stellate cells by targeting miR-206

(2017) Xinrui Han et al.   Oncotarget

Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice

(2017) Wenjun Lin et al.   Scientific Reports

Stat3 Controls Tubulointerstitial Communication during CKD

(2016) F. Bienaime et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tasquinimod treatment for prostate cancer

(2016) Vicki Brower   LANCET ONCOLOGY

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

(2016) Nicola Amodio et al.   MOLECULAR CANCER THERAPEUTICS

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Epithelial Plasticity versus EMT in Kidney Fibrosis

(2016) Shizheng Huang et al.   TRENDS IN MOLECULAR MEDICINE

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

(2016) Nathan R. Hill et al.   PLoS One

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Treatment of chronic kidney diseases with histone deacetylase inhibitors

(2015) Na Liu et al.   Frontiers in Physiology

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy

(2014) Xiaojie Wang et al.   KIDNEY INTERNATIONAL

Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer

(2014) Roberto Pili et al.   OncoTargets and Therapy

Mechanisms of action of tasquinimod on the tumour microenvironment

(2013) E. Raymond et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Histone deacetylases as targets for treatment of multiple diseases

(2013) Jinhua Tang et al.   CLINICAL SCIENCE

A review of tasquinimod in the treatment of advanced prostate cancer

(2013) Rakesh Heer et al.   Drug Design Development and Therapy

The role of the Janus kinase family/signal transducer and activator of transcription signaling pathway in fibrotic renal disease

(2012) Futoshi Matsui et al.   JOURNAL OF SURGICAL RESEARCH

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

EGFR Signaling Promotes TGF -Dependent Renal Fibrosis

(2011) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition

(2011) Emmanuel Charbonney et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

(2010) András Masszi et al.   JOURNAL OF CELL BIOLOGY

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

Renal recovery following acute kidney injury

(2008) Etienne Macedo et al.   Current Opinion in Critical Care

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL