αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy

Contrast-Associated Acute Kidney Injury

(2019) Roxana Mehran et al.   NEW ENGLAND JOURNAL OF MEDICINE

NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation

(2019) Shu Li et al.   EXPERIMENTAL CELL RESEARCH

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion Injury

(2018) Yingying Qian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

(2018) Steven D. Weisbord et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Klotho controls the brain–immune system interface in the choroid plexus

(2018) Lei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice

(2017) Alessandra Bitto et al.   INFLAMMATION RESEARCH

Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial

(2017) Estelle C Nijssen et al.   LANCET

Autophagy and inflammasomes

(2017) James Harris et al.   MOLECULAR IMMUNOLOGY

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

(2017) Natasha Irrera et al.   Frontiers in Pharmacology

NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis

(2016) Jianxiao Shen et al.   Scientific Reports

 Klotho Mitigates Progression of AKI to CKD through Activation of Autophagy

(2015) M. Shi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Contemporary Incidence, Predictors, and Outcomes of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions

(2014) Thomas T. Tsai et al.   JACC-Cardiovascular Interventions

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice

(2013) Alessandra Bitto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Klotho has dual protective effects on cisplatin-induced acute kidney injury

(2013) Monica C. Panesso et al.   KIDNEY INTERNATIONAL

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Oxidative stress in vascular disease and its pharmacological prevention

(2013) Huige Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy protects proximal tubular cells from injury and apoptosis

(2012) Gur P. Kaushal   KIDNEY INTERNATIONAL

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function

(2010) Matthew T. James et al.   KIDNEY INTERNATIONAL

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

(2010) Ming-Chang Hu et al.   KIDNEY INTERNATIONAL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Prevention of radiocontrast medium–induced nephropathy using short-term high-dose simvastatin in patients with renal insufficiency undergoing coronary angiography (PROMISS) trial—a randomized controlled study

(2008) Sang-Ho Jo et al.   AMERICAN HEART JOURNAL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE