Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury via SIRT6-Mediated Autophagy Activation

SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1

(2022) Xiao Sun et al.   CELL DEATH AND DIFFERENTIATION

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury

(2022) Sophia M. Sears et al.   JOURNAL OF LIPID RESEARCH

Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation

(2022) Ying Zhao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis

(2022) Lu Zhou et al.   Oxidative Medicine and Cellular Longevity

Polydatin: A Critical Promising Natural Agent for Liver Protection via Antioxidative Stress

(2022) Dandan Tang et al.   Oxidative Medicine and Cellular Longevity

SIRT6 Protects Against Myocardial Ischemia–Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation

(2022) Xiaokang Li et al.   Journal of Cardiovascular Translational Research

Is Autophagy Always a Barrier to Cisplatin Therapy?

(2022) Jingwen Xu et al.   Biomolecules

SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation

(2021) Zhiya Deng et al.   Cell Death & Disease

SIRT6 in Senescence and Aging-Related Cardiovascular Diseases

(2021) Xiaokang Li et al.   Frontiers in Cell and Developmental Biology

Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis

(2021) Sophia M. Sears et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Polydatin Induces Differentiation and Radiation Sensitivity in Human Osteosarcoma Cells and Parallel Secretion through Lipid Metabolite Secretion

(2021) Amalia Luce et al.   Oxidative Medicine and Cellular Longevity

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

(2021) Fulvio Perrella et al.   Biomolecules

Polydatin, a Glycoside of Resveratrol, Induces Apoptosis and Inhibits Metastasis Oral Squamous Cell Carcinoma Cells In Vitro

(2021) Tae-Hyun Bang et al.   Pharmaceuticals

Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin

(2021) Amir Hossein Doustimotlagh et al.   Clinical Nutrition ESPEN

Sirtuin 6 regulates macrophage polarization to alleviate sepsis-induced acute respiratory distress syndrome via dual mechanisms dependent on and independent of autophagy

(2021) Qian-Lu Wang et al.   CYTOTHERAPY

Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy

(2021) Xiaoru Hu et al.   Cancers

Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In Vitro

(2021) Marta De Angelis et al.   Biomedicines

Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4

(2021) Jing Tong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

(2020) Youguang Gao et al.   Journal of Translational Medicine

Polydatin protects SH-SY5Y in models of Parkinson's disease by promoting Atg5-mediated but parkin-independent autophagy

(2020) Hua Bai et al.   NEUROCHEMISTRY INTERNATIONAL

Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity

(2020) Keum-Young So et al.   CELL BIOLOGY AND TOXICOLOGY

Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy

(2020) Xiaoyan Yuan et al.   INFLAMMATION

Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells

(2020) Chang-qing Jiang et al.   Journal of Natural Medicines

Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway

(2020) Xiaoye Fan et al.   Frontiers in Pharmacology

Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling

(2020) Juan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

New intriguing possibility for prevention of coronavirus pneumonitis: Natural purified polyphenols

(2020) Lorenzo Lo Muzio et al.   ORAL DISEASES

Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy

(2020) Yaling Li et al.   Frontiers in Pharmacology

Polydatin enhances glomerular podocyte autophagy homeostasis by improving Nrf2-dependent antioxidant capacity in fructose-fed rats

(2020) Ting-Ting Gu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Polydatin alleviates high-fat diet induced atherosclerosis in apolipoprotein E-deficient mice by autophagic restoration

(2020) Qingping Xiong et al.   PHYTOMEDICINE

Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway

(2020) Xiaoye Fan et al.   Frontiers in Pharmacology

Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome

(2019) Tao Li et al.   LABORATORY INVESTIGATION

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling

(2019) Jian Guo et al.   CIRCULATION RESEARCH

Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy

(2019) Yang Zhang et al.   CELL CYCLE

Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

(2019) Luigi Mele et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock

(2019) Siqi Xu et al.   Frontiers in Physiology

Micronized Palmitoylethanolamide-Polydatin Reduces the Painful Symptomatology in Patients with Interstitial Cystitis/Bladder Pain Syndrome

(2019) M. Cervigni et al.   Biomed Research International

Protective effects of polydatin on multiple organ ischemia-reperfusion injury

(2019) Zhicheng Sun et al.   BIOORGANIC CHEMISTRY

Polydatin prevents LPS-induced acute kidney injury through inhibiting inflammatory and oxidative responses

(2019) Lina Gu et al.   MICROBIAL PATHOGENESIS

SIRT6 protects against hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy related cell death

(2018) Song Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling

(2018) Zhongchi Li et al.   KIDNEY INTERNATIONAL

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

(2018) Jing Liu et al.   Cell Death & Disease

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway

(2017) Baojun Yang et al.   OncoTargets and Therapy

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux

(2016) Y. Ling et al.   CLINICAL SCIENCE

Polydatin ameliorates renal ischemia/reperfusion injury by decreasing apoptosis and oxidative stress through activating sonic hedgehog signaling pathway

(2016) Qiu-hong Meng et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial DysfunctionviaSIRT1 Activation and p53 Deacetylation

(2016) Zhenhua Zeng et al.   Oxidative Medicine and Cellular Longevity

Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis-Induced Acute Kidney Injury

(2015) Youguang Gao et al.   ANESTHESIA AND ANALGESIA

Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway

(2015) Hong-Bao Liu et al.   Oxidative Medicine and Cellular Longevity

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL