Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62‐Keap1‐Nrf2 signaling pathway

Pomegranate bioactive constituents target multiple oncogenic and oncosuppressive signaling for cancer prevention and intervention

(2021) Tin Lok Wong et al.   SEMINARS IN CANCER BIOLOGY

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

(2021) Weiwei Xia et al.   Cell Death & Disease

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis

(2021) Guangying Shao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

(2021) Davide D’Amico et al.   TRENDS IN MOLECULAR MEDICINE

Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathways

(2021) Zhenzhen Cheng et al.   Journal of Functional Foods

Continuous Renal Replacement Therapy Liberation and Outcomes of Critically Ill Patients With Acute Kidney Injury

(2021) Chang Liu et al.   MAYO CLINIC PROCEEDINGS

Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway

(2020) Dechong Zheng et al.   PHARMACOLOGICAL RESEARCH

Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases

(2020) Houman Kahroba et al.   BIOCHIMIE

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice

(2020) Bo Xia et al.   PLOS BIOLOGY

Inflammation and Premature Ageing in Chronic Kidney Disease

(2020) Thomas Ebert et al.   Toxins

Pterostilbene Alleviates Aβ 1‐42 ‐Induced Cognitive Dysfunction via Inhibition of Oxidative Stress by Activating Nrf2 Signaling Pathway

(2020) Jikai Xu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Protective effect of urolithin a on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress

(2019) Taile Jing et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

(2019) Zehan Tang et al.   Cell Death & Disease

Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A

(2019) Ying Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Urolithin A shows anti-atherosclerotic activity via activation of class B scavenger receptor and activation of Nef2 signaling pathway

(2018) Guang-Hao Cui et al.   Pharmacological Reports

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging

(2018) A. Cortés-Martín et al.   Food & Function

p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer

(2018) Pablo Sánchez‐Martín et al.   FEBS Journal

Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells

(2018) Stephanie F. Smith et al.   KIDNEY INTERNATIONAL

Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model

(2017) Melissa Guada et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression

(2017) Masahiro Nezu et al.   KIDNEY INTERNATIONAL

Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases

(2016) Piu Saha et al.   PLoS One

Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

(2015) D. P. Basile et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Oxidative stress and autophagy: Crucial modulators of kidney injury

(2015) Angara Sureshbabu et al.   Redox Biology

Acute kidney injury—epidemiology, outcomes and economics

(2014) Oleksa Rewa et al.   Nature Reviews Nephrology

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL

Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health

(2011) J.M. Landete   FOOD RESEARCH INTERNATIONAL

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

(2010) Man Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Heme Oxygenase-1 Inhibits Renal Tubular Macroautophagy in Acute Kidney Injury

(2010) S. Bolisetty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

(2008) Sudharsan Periyasamy-Thandavan et al.   KIDNEY INTERNATIONAL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE