Pathophysiological Roles of the cGAS-STING Inflammatory Pathway

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

(2022) Jeremy Di Domizio et al.   NATURE

cGAS‐STING mediates cytoplasmic mitochondrial‐DNA‐induced inflammatory signal transduction during accelerated senescence of pancreatic β‐cells induced by metabolic stress

(2022) Huiqing Hu et al.   FASEB JOURNAL

Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury

(2022) Li Chen et al.   HEPATOLOGY

Type I interferon–related kidney disorders

(2022) Lorenzo Lodi et al.   KIDNEY INTERNATIONAL

A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis

(2022) Dan Zhang et al.   NATURE CELL BIOLOGY

Deficiency in coatomer complex I causes aberrant activation of STING signalling

(2022) Annemarie Steiner et al.   Nature Communications

Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation

(2022) Xiaowen Ma et al.   HEPATOLOGY

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

(2022) Hanna Lucie Sladitschek-Martens et al.   NATURE

Targeting STING to promote antitumor immunity

(2022) Emily N. Chin et al.   TRENDS IN CELL BIOLOGY

Combination of the STING Agonist MIW815 and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-label, Multicenter, Phase Ib Study

(2022) Funda Meric-Bernstam et al.   CLINICAL CANCER RESEARCH

Activation of Stimulator of Interferon Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases

(2022) Alla Mitrofanova et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax

(2022) Jingyao Li et al.   KIDNEY INTERNATIONAL

cGAS-STING activation contributes to podocyte injury in diabetic kidney disease

(2022) Nan Zang et al.   iScience

Homeostatic regulation of STING by retrograde membrane traffic to the ER

(2021) Kojiro Mukai et al.   Nature Communications

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

(2021) Seoyun Yum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmentation of STING‐induced type I interferon production in COPA syndrome

(2021) Takashi Kato et al.   Arthritis & Rheumatology

cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

(2021) Mona Motwani et al.   Frontiers in Immunology

A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

(2021) Thaneas Prabakaran et al.   EBioMedicine

Pharmacological activation of STING blocks SARS-CoV-2 infection

(2021) Minghua Li et al.   Science Immunology

Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

(2021) Liraz Shmuel-Galia et al.   IMMUNITY

APOL1 at 10 years: progress and next steps

(2021) Barry I. Freedman et al.   KIDNEY INTERNATIONAL

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

(2021) Ting-Ting Chu et al.   NATURE

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

(2021) Anna K. Uryga et al.   Communications Biology

GRP75 Regulates Mitochondrial-Supercomplex Turnover to Modulate Insulin Sensitivity

(2021) Qiongya Zhao et al.   DIABETES

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

(2020) Katherine R. Balka et al.   Cell Reports

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome

(2020) Xiaodong Mu et al.   AGING CELL

Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

(2020) Ilgen Mender et al.   CANCER CELL

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

(2020) Jianjun Wu et al.   IMMUNITY

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)

(2020) Bin Lin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

(2020) Zimu Deng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

(2020) Alice Lepelley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease

(2020) Ruihua Ma et al.   FASEB JOURNAL

COPA silences STING

(2020) Sophie Rivara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

C9orf72 in myeloid cells suppresses STING-induced inflammation

(2020) Madelyn E. McCauley et al.   NATURE

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models

(2019) Mona Motwani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

(2019) Carina C. de Oliveira Mann et al.   Cell Reports

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Pathophysiological Role of Organelle Stress/Crosstalk in AKI-to-CKD Transition

(2019) Hiroshi Maekawa et al.   SEMINARS IN NEPHROLOGY

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

(2019) Mégane Nascimento et al.   Scientific Reports

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

(2018) Yasuhiro Kato et al.   ANNALS OF THE RHEUMATIC DISEASES

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation

(2018) Chun-Seok Cho et al.   HEPATOLOGY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING

(2018) Hiroyasu Konno et al.   Cell Reports

Elevated IFIT3 Contributes to Abnormal Overactive cGAS-STING Signaling in Human Systemic Lupus Erythematosus Monocytes

(2018) Jiehua Wang et al.   Arthritis & Rheumatology

TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors

(2018) Brian J. Francica et al.   Cancer Immunology Research

Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

(2018) Yuzhu Hou et al.   IMMUNITY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

STING promotes homeostasis via regulation of cell proliferation and chromosomal stability

(2018) Diana Rose E. Ranoa et al.   CANCER RESEARCH

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

(2018) Sulayman Benmerzoug et al.   Nature Communications

Palmitic acid dysregulates the Hippo–YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS–STING–IRF3 signaling mechanism

(2017) Liangshuai Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING-associated vasculopathy develops independently of IRF3 in mice

(2017) James D. Warner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

DNA sensing in senescence

(2017) Marina Ruiz de Galarreta et al.   NATURE CELL BIOLOGY

miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS

(2017) Min-Zu Wu et al.   NATURE CELL BIOLOGY

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

(2017) Hua Liang et al.   Nature Communications

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis

(2017) Jeonghyun Ahn et al.   Cell Reports

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus

(2017) Jie An et al.   Arthritis & Rheumatology

Stress Signal Network between Hypoxia and ER Stress in Chronic Kidney Disease

(2017) Hiroshi Maekawa et al.   Frontiers in Physiology

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Systemic lupus erythematosus

(2016) Arvind Kaul et al.   Nature Reviews Disease Primers

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

(2015) Levi B Watkin et al.   NATURE GENETICS

Suppression of systemic autoimmunity by the innate immune adaptor STING

(2015) Shruti Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells

(2014) Jared Klarquist et al.   JOURNAL OF IMMUNOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

The evolving understanding of COPI vesicle formation

(2009) Victor W. Hsu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE