APOL1 at 10 years: progress and next steps

Association of APOL1 Risk Genotype and Air Pollution for Kidney Disease

(2020) Ishan Paranjpe et al.   Clinical Journal of the American Society of Nephrology

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney specific pathways.

(2020) Archna Bajaj et al.   KIDNEY INTERNATIONAL

Association of preeclampsia with infant APOL1 genotype in African Americans

(2020) Anna K. Miller et al.   BMC Medical Genetics

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

(2020) Sophie Uzureau et al.   Cell Reports

Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

(2020) Joseph A Giovinazzo et al.   eLife

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function

(2020) Somenath Datta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL1 High-Risk Genotype

(2020) Huijuan Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes

(2020) Suzie J. Scales et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

(2020) Nidhi Gupta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19

(2020) Juan Carlos Q. Velez et al.   Nature Reviews Nephrology

Podocytopathies

(2020) Jeffrey B. Kopp et al.   Nature Reviews Disease Primers

APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

(2020) Hidefumi Wakashin et al.   BMC Nephrology

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

(2019) Justin Chun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JC viruria associates with reduced risk of diabetic kidney disease

(2019) Etty Kruzel-Davila et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program

(2019) Alexander G. Bick et al.   CIRCULATION

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

(2019) Jung-Hwa Ryu et al.   PLoS One

APOL1 Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis

(2019) Morgan E. Grams et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

(2019) Shrijal S. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background

(2019) Herbert Lannon et al.   KIDNEY INTERNATIONAL

Genetic Testing for APOL1 Genetic Variants in Clinical Practice: Finally Starting to Arrive

(2019) Jeffrey B. Kopp et al.   Clinical Journal of the American Society of Nephrology

Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway

(2019) Shamara E. Davis et al.   Scientific Reports

Plasma biomarkers are associated with renal outcomes in individuals with APOL1 risk variants

(2018) Girish N. Nadkarni et al.   KIDNEY INTERNATIONAL

Genome-wide association studies suggest that APOL1 -environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1 –second gene interactions

(2018) Carl D. Langefeld et al.   KIDNEY INTERNATIONAL

UBDmodifiesAPOL1-induced kidney disease risk

(2018) Jia-Yue Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

(2018) Pazit Beckerman et al.   TRENDS IN MOLECULAR MEDICINE

Fetal—Not Maternal—APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry

(2018) Kimberly J. Reidy et al.   AMERICAN JOURNAL OF HUMAN GENETICS

APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD

(2018) Barry I. Freedman et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

(2017) Salim S Hayek et al.   NATURE MEDICINE

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy

(2017) Karl L Skorecki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It?

(2017) Opeyemi A. Olabisi et al.   SEMINARS IN NEPHROLOGY

Apolipoprotein L1 Gene Effects on Kidney Transplantation

(2017) Barry I. Freedman et al.   SEMINARS IN NEPHROLOGY

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense

(2016) Anneli Cooper et al.   PLoS Neglected Tropical Diseases

APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans

(2015) A. N. Kasembeli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects

(2015) M. G. Sampson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

(2015) Brendan Nichols et al.   KIDNEY INTERNATIONAL

Hypertension-attributed nephropathy: what's in a name?

(2015) Barry I. Freedman et al.   Nature Reviews Nephrology

Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis

(2015) Russell Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 Kidney Disease Risk Variants: An Evolving Landscape

(2015) Patrick D. Dummer et al.   SEMINARS IN NEPHROLOGY

Identifying Darwinian Selection Acting on Different Human APOL1 Variants among Diverse African Populations

(2013) Wen-Ya Ko et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

(2013) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy

(2013) Jasmin Divers et al.   KIDNEY INTERNATIONAL

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

MYH9 and APOL1 are both associated with sickle cell disease nephropathy

(2011) Allison E. Ashley-Koch et al.   BRITISH JOURNAL OF HAEMATOLOGY

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans

(2010) B. I. Freedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE